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Taking Novel / Atypical Antipsychotics

 

 

 

 

 

 
  1. What is a big deal is to avoid alcohol with antipsychotics. I didn't when I was first on Risperdal and I think some occasional heavy drinking contributed to my nervous breakdown on or about my birthday in February of 2002. Mixing alcohol and benzodiazepines can be fatal. Mixing alcohol and anticonvulsants is weird. Mixing alcohol and most modern antidepressants is generally not a big deal. But mixing alcohol and antipsychotics can seriously mess with your head, sometimes with long-lasting results. Here is an example of what a couple of glasses of wine and a low dosage of Seroquel (quetiapine)  can do to someone in distress and looking for support on an Internet support group. Normally this person can type proficiently:
  2.  

    siorry jmy popst lioikds l;ielk i am druikn

    i dont driglk

    i am toooo tired ot tyo;pw

    i dolnt droinkkkkk

    mky yese asre all mlessed ujp form anothner drugnnnnnnnand i haove a sevfer

    healtdcalcl]]\

    myua got toe er donot nfelel l ewelll at allllllllll

    strfated birth donltroel pil;ls as fewa daYs ago

    for metopauose

    tye agian tomoerowow

     

    ---

     

    Then, twenty minutes later:

     

    theklank s brina

    i have nbmb halnds and at heatdacah e

    form new pillllllllllls well lsee dr tabout that domtoorrow

    what isss keoppera?

     

    caleed nursre aboutj mmmmy porblem wriantnng and wiath the bumv b'handedss

    wils se dorctor tomeorw

     

    headabke very bnead anow to gbed now

    head burts

    beok soom

    gonit wondw worry pplaese

     

  3. The withdrawal has been likened to taking small amounts of psychedelic drugs. Whether that is a good or bad thing is up to individual experience. Others get rebound symptoms for a day or two, sometimes longer and that's about it. Of course, that's for issues where it's OK to stop taking meds at some point, like panic/ anxiety disorders.  The big problem is that the bipolar and the schizophrenic are the worst about stopping their meds because they think they're cured when their symptoms stop.  Wrong answer!  Your symptoms stop because the meds are working.  As of the early 21st century there are no cures for these disorders, just management of symptoms.  The good news is you can just start right back up on the atypicals and get back to where you were in controlling your symptoms.


     

 

  1. One great thing about antipsychotics is that you can take them as required (or PRN in medical shorthand). Feeling just a bit too anxious or manic? Try some Risperdal (risperidone) or Zyprexa (olanzapine) instead of increasing your normal amount of benzos or mood stabilizers / anticonvulsants. Once you feel stable, you can just stop taking the extra antipsychotics. Let me stress the extra part. If an antipsychotic is your primary medication and you're feeling just great you have to keep taking your maintenance dosage, whatever that may be. Now you can discuss with your doctor about taking a lower dosage and seeing how that works out. These meds are very flexible when it comes to dosages. Go up, go down, in the long run it turns out to be OK as they are far less picky than the anticonvulsants.
  2. Even though I was skeptical at first and thought the real reason for pushing antipsychotics for bipolar and anxiety was money, I'm starting to come around to them. On the bipolar side of things several act as true mood stabilizers for some people, helping with both mania and depression. They are perfect for the non-compliant, which defines the schizophrenic and bipolar, as some have long half-lives and they work just fine if you stop taking them and start up again. The combination of atypical antipsychotics and antidepressants is being shown to be the best thing since sex to combat bipolar depression and refractory unipolar depression.

  3. Conversion for atypicals. This is just an approximation, in case you need to switch from one of the popular atypical antipsychotics to another quickly because of adverse effects. Obviously 3mg of Abilify  (aripiprazole) will not sedate you like 100mg of Seroquel (quetiapine). I've placed them from the most to least potent to give you an idea of what the range is like. Note that Risperdal (risperidone) is 200 times as potent as Seroquel (quetiapine).  Depending on how your symptoms are acting up it's between you and your doctor if you want to stop taking one on Friday and start taking another on Saturday (or whenever you can schedule time off for a med change).  While switching SSRIs isn't as big a deal, it's just a matter of some drug clearances (i.e. you won't clear out the meds as quickly when you have two of them in your system at the same time), having two antipsychotics in your system at the same time does make it somewhat more likely that you could experience EPS or even NMS.  These work only for the starting dosages.  These things aren't exactly linear, therefore at the higher dosages they don't exactly map out.  So if you're switching from a high dosage of one to another your doctor is probably writing you a prescription that makes a lot a sense.  If you want to try to do the math yourself, see the NIMH Psychoactive Drug Screening Program.  If you ask me how to use that site, you're not qualified to use it.

    0.5mg Risperdal (risperidone) = 2.5mg Zyprexa (olanzapine)  = 3mg  Abilify  (aripiprazole) = 20mg Geodon (ziprasidone HCl) = 100mg Seroquel (quetiapine) = you only want to take Clozaril (clozapine) if you're really messed up and nothing else is going to work.  OK, Clozaril (clozapine) works on your brain in a completely different way as well, so there's not an easy dosage equivalent.  Plus it has some very specific uses that are different from the other atypicals. 

    The same applies to switching between a standard/typical antipsychotic and an novel/atypical.  They do the same sort of thing, but in slightly different ways.  People do it all the time, I just don't know an easy equivalent.  Plus you really want to have whatever you're switching from out of your system before you start what you're switching to, unless the side effects are completely horrible and your symptoms are even worse.  As above, you just increase the risk of EPS or even NMS with the two types of antipsychotics in your system.  It's all a matter of figuring out which is more dangerous, the very small risk of EPS or NMS, or the chance of your doing something very dangerous to yourself or others if you're not medicated enough.

 

 

Basic Information About Atypical Antipsychotics  Common Side Effects  Extrapyramidal Symptoms (EPS) / Tardive Dyskinesia (TD) / Neuroleptic Malignant Syndrome  (NMS)  Long-Term Issues of Atypical Antipsychotics

 

 

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Atypical Antipsychotics in the News

 

 

 

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If you still have unanswered questions about this or other medications, including which one is, or combination of meds are the best for you, your best bet is to ask on Crazy Meds Talk.  Better yet, if you want to let the world know how they worked out for you and want to help out others in their quest for the correct meds, join the party.
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Another problem is that you may not get a response even if I wanted to send you one.  You see, so many dickweeds with malicious intents and too much time on their hands have appropriated the crazymeds.org domain name to use for their spam, viruses and the like.  Subsequently some lazy-ass e-mail protection software authors just go by the domain name, and not the IP address.  So I've been blacklisted because of the actions of others.  Or the software just doesn't like the domain name because of the "crazy" and/or "meds."  Or your question about a particular medication will set off spam flags.  So the e-mail just wouldn't go through regardless.  Sorry.

  

 

 

Hey, did you find this page all by itself through Google or some other search engine? Great! But to really appreciate the entire site, you need to start here.

 

Dead tree references:

 

 

Essential Psychopharmacology Stephen M. Stahl, M.D., Ph. D. © 2000.   Published by  Cambridge University Press

 

A Primer of Drug Action Robert M. Julien, M.D., Ph. D. © 2001.  We use the Ninth Edition.  Sometimes that comes up on an Amazon search, usually it doesn't.  Published by  Worth Publishers

 

 

Physicians' Desk Reference Editions 53 & 56 Maria Deutsch & Anu Gupta, Drug Information Specialists, et al. ©  1999, 2002. Published by Medical Economics Company.

 

The Complete Guide to Psychiatric Drugs Edward Drummond, M.D. © 2000. Published by John Wiley & Sons, Inc.

 

 

End of books used for this article.

 

 

 

 

Created Thursday, October 07, 2004

Last updated Saturday, May 15, 2010

 

Copyright © 2003 - 2010 Jerod Poore All rights reserved.

 

Almost all of the material on this site is Copyright © 2003 - 2010 Jerod Poore Except, of course, the PI sheets, those are the property of the drug companies who developed the drugs the sheets are about.  And any documents that are written by other people which may be posted to this site will remain the property of the original authors.  You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder.  That's usually me, so just ask first.  That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that's OK to just do.  Go for it!  Please.  As long as you include this copyright notice and the following disclaimer, I'm cool with it.

All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won't necessarily happen to you. Nobody on this site is a doctor, therapist, or a pharmacist. We don't portray them either here or on TV. Only doctors can diagnose and treat an illness. Some doctors tend to get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don't be a cyberchondriac, thinking you have every disease you see a website about, or that you'll get every side effect from every medication. Self-prescribing is just as dangerous.  All information on this site has been obtained through personal experience, the experiences of my friends, the experiences of people reported on online support groups, and from sources that are referenced throughout the site.  Know your sources!  As such the information presented here is not a substitute for real medical advice from your real doctor, just a compliment to it.  No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. All brand names of the drugs listed in this site are the trademarks of the companies listed after them in the pages about the drugs, even though those companies may or may not have been acquired by other companies who may or may not be listed in this site by the time you read this. Always read the PI sheet that comes with your medications and never ever throw them away.  If you didn't get a PI sheet, demand one.  Loudly.  Crazy Meds is not responsible for the content of sites we provide links to.  We like them, or they're paid advertisements, or they're something you should read to make an informed decision about a particular med.  Sometimes they're more than one of those things.  But what's on those sites is their business, not ours.  Very little information about visitors to this site is collected or saved. And from time to time I do look at search terms used to find it in an effort to make the information I present more relevant. Use only as directed. Void where prohibited.

 

"Everything is true, nothing is permitted." - Jerod Poore