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‹< Zoloft’s Pharmacology |

US brand name: Zoloft
Generic name: sertraline

Comments

While Zoloft is no more likely to trigger mania than any other SSRI, due to that dopaminergic kick the symptoms it triggers are a lot worse. Zoloft just gets you way more agitated and sets of these nasty dysphoric manias in the bipolar, which can be a very harsh way to discover that one is bipolar. With the other SSRIs and SNRIs it’s a coin toss as to whether they’ll trigger euphoric manias that will send you on spending sprees or marrying people you just meet, or trigger dysphoric manias that make you destroy all the furniture in a room. But with Zoloft the odds are heavily in favor of the dysphoric mania. That may be why the poor little Zoloft lozenge quit shilling Zoloft so heavily for depression, and now primarily touts its efficacy for social anxiety, panic disorder, PTSD, and PMDD. Then again it could be that Zoloft is just testing better in studies for its other approved uses. In any event, that’s you need to be extra careful with Zoloft, more than most others antidepressants, when it comes to watching out for suicidal thoughts and behavior.

Name, Address, Serial Number (Generic and Overseas Availability)

Available in the US as a generic? Yes

Shapes & Sizes (How Supplied)

  • 25 mg tablet
  • 50 mg tablet
  • 100 mg tablet
  • 20mg/mL oral concentrate

OK, Pfizer keeps telling us that there’s not much evidence that Zoloft works any better at dosages above 50mg a day, so the 100mg tablets must be so you can split them in half and save money, right? And if the recommended dosage for everything is 50mg a day, why the hell is the oral concentrate the equivalent of a non-existent 20mg tablet?



Other Trade Names and Overseas Availability

Not including controlled/extended/sustained release suffixes (Efexor ER, Trevilor retard e.g.) or branded generics that are a hyphenate of the generic name and the drug company name (Apo-Citalopram e.g.).

Available as Zoloft in These Countries

Argentina, Brazil, Bulgaria, Canada, China, Czech Republic, Denmark, Finland, France, Germany, Hong Kong, Hungary, Indonesia, Italy, Korea, Malaysia, Netherlands, Peru, Philippines, Poland, Sweden, Switzerland, Taiwan, Thailand, Uruguay, Venezuela

Available as Generic Sertraline in These Countries

Belgium (probably the entire EU by now), Colombia, Brazil, Indonesia, Korea, Malaysia, Thailand

Transliterated, Overseas Trade and Branded Generic Names

  • Altruline : Mexico
  • Aremis : Spain
  • Atruline : Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama
  • Besitran : Spain
  • Deprax : Chile
  • Dominum : Colombia, Peru
  • Doxime : Paraguay
  • Gladem : Austria, Germany
  • Lesefer : Colombia
  • Lustral : England, Ireland, Israel
  • Sosser : Colombia
  • Zolof : Colombia
  • Zosert : India
  • Fatral : Indonesia
  • Fridep : Indonesia
  • Nudep : Indonesia
  • Seltra : Korea
  • Sercerin : Brazil
  • Serlain : Belgium
  • Serlift : Malaysia
  • Sertranex : Colombia
  • Sertranquil : Colombia
  • Traline : Korea

Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, and Other Sites that may be of Interest

Zoloft’s Full US Prescribing Information / PI Sheet

Official Sites

Official US Zoloft site It’s basically the PI sheet and an application for a $4.00 copay card

Rating & Review Sites

Other Sites of Interest

DrugsDB.com’s Zoloft Page



Discussion board

If you have any questions not answered here, please see the Crazymeds Zoloft discussion board.

References

  1. Zoloft’s Full US Prescribing Information
  2. Faught, Edward. “Topiramate in the treatment of partial and generalized epilepsy.” Neuropsychiatric disease and treatment 3.6 (2007): 811-821.
  3. Obach, R. Scott, Loretta M. Cox, and Larry M. Tremaine. “Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study.” Drug metabolism and disposition 33.2 (2005): 262-270.
  4. Kobayashi, Kaoru, Tomoko Ishizuka, Noriaki Shimada, Yoshitaka Yoshimura, Kunitoshi Kamijima, and Kan Chiba. “Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro.” Drug metabolism and disposition 27, no. 7 (1999): 763-766.
  5. Stahl, Stephen M. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Third edition Cambridge University Press 2008. ISBN:978–0521673761
  6. Julien, Robert M. Ph.D, Claire D. Advokat, and Joseph Comaty Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs 12th edition Worth Publishers 2011. ISBN:978–1429233439
  7. Stahl, Stephen M. The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition Cambridge University Press 2009. ISBN:978–0521743990
  8. Virani, Adil S., K. Bezchlibnyk-Butler, and J. Jeffries Clinical Handbook of Psychotropic Drugs 18th edition Hogrefe & Huber Publishers 2009. ISBN:978–0889373693
  9. Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series) © 2007 ISBN:978-0323040587 An imprint of Elsevier
  10. Instant Psychopharmacology 2nd Edition Ronald J. Diamond MD © 2002. ISBN:978-0393703917 Published by W.W. Norton.
  11. The Complete Guide to Psychiatric Drugs Edward Drummond, MD © 2000. ISBN:0471353701 Published by John Wiley & Sons, Inc.
  12. PDR: Physicians’ Desk Reference 2010 64th edition
  13. Healing Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, M.D. © 2003. Published by G.P. Putnam’s Sons.
  14. Sheldon Preskorn’s Applied Clinical Psychopharmacology www.preskorn.com Sheldon Preskorn, M.D. Chief Executive Officer of the Clincal Research Institute and a Professor in the Department of Psychiatry and Behavioral Sciences at the University of Kansas School of Medicine - Wichita Last Accessed 08 July 2014

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Last modified on Wed, 04 May, 2016 at 18:02:23 by JerodPoorePage Author Date created Wednesday, 06 April 2011, at 14:28:00
“Zoloft (sertraline): Availability, Comments, Links, More” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/04/06

Zoloft, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Zoloft’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.



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