‹< Wellbutrin’s Pharmacology |

US brand name: Wellbutrin
Generic name: bupropion


While Wellbutrin has the potential make you happy, horny, skinny, and quit smoking, it is only consistent at making you not depressed - which probably counts as happy so long as you don’t end up all irritable, anxious, and pissed off1 - and helping you to stop smoking, while being unlikely to make you gain weight or affect your libido. Weight loss and treating sexual dysfunction are off-label uses of Wellbutrin and, like most off-label uses, you only want to try it if the regular treatments don’t work, because the odds aren’t as good or the side effects are worse. Or both.

Really, Dr. Drew… oh, wait, Dr. Drew just took GSK’s money and told everyone the facts as they were known - like it is less likely to cause weight gain or sexual side effects than SSRIs - except for that part about taking a shitload of money from GSK. It was another doctor, who wasn’t as famous, who was repeating what the pharm reps were telling him about the happy, horny, skinny pill. Maybe. If you don’t need it to keep from falling to the floor in a fetal position and sobbing for hours if the newspaper reprinted yesterday’s sudoku. They should have known better than that.

There’s more news. The FDA pulled the approval of Teva/Impax 300 mg Budeprion XL.2 I have more information about that on the Generic Availability page, the Expanded Comments page, and in a topic about this on the Crazy Talk forum.

Name, Address, Serial Number (Generic and Overseas Availability)

Available in the US as a generic? Yes

Shapes & Sizes (How Supplied)

  • Wellbutrin:
    • Immediate Release - 75mg & 100mg tablets
    • Sustained Release (SR) - 100mg, 150mg & 200mg tablets
    • Extended Release (XL) - 150mg & 300mg tablets
  • Aplenzin:
    • 174mg, 348mg & 522mg tablets

Other Trade Names and Overseas Availability

Not including controlled/extended/sustained release suffixes (Efexor ER, Trevilor retard e.g.) or branded generics that are a hyphenate of the generic name and the drug company name (Apo-Citalopram e.g.).

Branded Generic Names

  • Aplenzin (bupropion hydrobromide)
  • Budeprion

Available as Wellbutrin in:

  • Canada
  • Also available as Zyban in:
    • Australia, Canada, EU, Ireland, New Zealand (specified as a second-line treatment due to side effects)

Overseas Trade and Branded Generic Names

  • Prexaton - Australia

Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, and Other Sites that may be of Interest

Wellbutrin’s Full US Prescribing Information / PI Sheet

PI Sheets for Other Forms

Official Sites

Rating & Review Sites

Other Sites of Interest

Discussion board

If you have any questions not answered here, please see the Crazymeds Wellbutrin discussion board.


  1. Stahl, Stephen M. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Third edition Cambridge University Press 2008. ISBN:978–0521673761
  2. Julien, Robert M. Ph.D, Claire D. Advokat, and Joseph Comaty Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs 12th edition Worth Publishers 2011. ISBN:978–1429233439
  3. Stahl, Stephen M. The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition Cambridge University Press 2009. ISBN:978–0521743990
  4. Virani, Adil S., K. Bezchlibnyk-Butler, and J. Jeffries Clinical Handbook of Psychotropic Drugs 18th edition Hogrefe & Huber Publishers 2009. ISBN:978–0889373693
  5. Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series) © 2007 An imprint of Elsevier.
  6. Instant Psychopharmacology 2nd Edition Ronald J. Diamond MD © 2002. Published by W.W. Norton
  7. The Complete Guide to Psychiatric Drugs Edward Drummond, MD © 2000. Published by John Wiley & Sons, Inc.
  8. PDR: Physicians’ Desk Reference 2010
  9. Wellbutrin Immediate Release Full US PI sheet
  10. Wellbutrin Sustained Release Full US PI sheet
  11. Wellbutrin eXtended reLease Full US PI sheet
  12. Aplenzin Full US PI sheet
  13. Bupropion: What Mechanism of Action?
  14. Review of the Pharmacology and Clinical Profile of Bupropion, an Antidepressant and Tobacco Use Cessation Agent
  15. A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor
  16. Effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, in healthy subjects
  17. Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers
  18. Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites
  19. Tomarken, Andrew J., et al. “Assessing the effects of bupropion SR on mood dimensions of depression.” Journal of affective disorders 78.3 (2004): 235-241.
  20. Dunner, David L., et al. “Improved health-related quality of life and reduced productivity loss after treatment with bupropion sustained release: a study in patients with major depression.” Primary care companion to the Journal of clinical psychiatry 3.1 (2001): 10.
  21. Gualtieri, C. Thomas, and Lynda G. Johnson. “Bupropion normalizes cognitive performance in patients with depression.” Medscape General Medicine 9.1 (2007): 22.
  22. Fraile, M. Gutiérrez, et al. “Bupropion: Efficacy and safety in the treatment of depression.” Actas Esp Psiquiatr 39.Supl 1 (2011): 1-25.
  23. Leverich, Gabriele S., et al. “Risk of Switch in Mood Polarity to Hypomania or Mania in Patients With Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers.” Focus 5.1 (2007): 98.
  24. Saddichha, Sahoo, Ashish Soy, and Pandey Vibha. “Findings that shed new light on the possible pathogenesis of a disease or an adverse effect: Possible manic switch induced by combination of bupropion and electroconvulsive therapy in recurrent unipolar depression: a case series.” BMJ Case Reports 2009 (2009).
  25. Post, R. M., et al. “Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline.” The British Journal of Psychiatry 189.2 (2006): 124-131.
  26. Sachs, Gary S., et al. “Effectiveness of adjunctive antidepressant treatment for bipolar depression.” New England Journal of Medicine 356.17 (2007): 1711-1722.
  27. Truman, Christine J., et al. “Self-Reported History of Manic/Hypomanic Switch Associated With Antidepressant Use: Data From the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).(CME).” Journal of Clinical Psychiatry 68.10 (2007): 1472-1479.
  28. Gijsman, Harm J., et al. “Antidepressants for bipolar depression: a systematic review of randomized, controlled trials.” American Journal of Psychiatry 161.9 (2004): 1537-1547.
  29. Gao, Keming, and Joseph R. Calabrese. “Newer treatment studies for bipolar depression.” Bipolar disorders 7.s5 (2005): 13-23.
  30. Grunze, Heinz, et al. “The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2010 on the treatment of acute bipolar depression.” World Journal of Biological Psychiatry 11.2 (2010): 81-109.

‹< Wellbutrin’s Pharmacology |

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1 Along with other symptoms of a dysphoric mania. Not all manias are happy-happy joy-joy, kids.

2 Technically the FDA asked Teva & Impax to voluntarily remove Budeprion XL from the market, much like the way the IRS assists us in voluntary compliance with tax code. Go ahead, search irs.gov for the phrase "promote voluntary compliance", with or without quotes. I feel so much better about myself knowing I've been volunteering for my country.

Last modified on Wed, 04 May, 2016 at 18:00:59 by JerodPoorePage Author Date created 27 March 2011 at 14:50:23
“Wellbutrin (bupropion): Availability, Comments, Links, More” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/03/27

Wellbutrin, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Wellbutrin’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

Page design and explanatory material by Jerod Poore, copyright © 2003 - 2016. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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