Highlighting side effects, warnings, interactions, and more

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US brand name: Viibryd
Generic name: vilazodone

Viibryd’s Potential Side Effects

Potential Side Effects All Crazy Meds Have

No matter which neurological and/or psychiatric drug you take, you’ll probably get one or more of these side effects. These will usually be gone, or at least will diminish to the point where you barely notice it most of the time, within a week or two.

  • Headache
  • Drowsiness / fatigue - even when taking stimulants in some circumstances.
  • Insomnia, instead of or alternating with the drowsiness.
  • Nausea
  • Assorted other minor GI complaints (constipation, diarrhea, etc.)
  • Generally feeling spacey / out of it
    • Which can all add up to the ever-helpful “flu-like symptoms” listed as an adverse event on the PI sheet of practically every medication on the planet used to treat almost any condition humans and other animals could have.1
  • All crazy meds can, and probably will affect your dreams as well. There is no way of telling if that will be good or bad, let alone if this side effect is permanent or temporary.
  • Any of the above side effects you see listed again below means they’re even more likely to happen and/or stick around longer and/or are worse than most other meds.


Typical Potential Side Effects

Diarrhea, nausea & vomiting, the shits, excessive sleep or insomnia, and the runs.
I’m still trying to get a handle as to how common or uncommon, permanent or transient, sexual dysfunction and weight gain really are. The lack of weight gain could be a function of puking and/or shitting out everything you eat ten minutes later.

Uncommon Potential Side Effects

Dizziness, tremor, anxiety, and headaches that reach migraine intensity.

Even though it annoys me to no end that people freak out about strange dreams when taking medications that affects their brains, especially since I have written all over this site that “ALL crazy meds can affect your dreams,” for an antidepressant Viibryd seems to really mess with people’s dreams.

Freaky Rare Side Effects

Pollakiuria. In English: an overactive bladder. Viibryd is just way too new to have any decent freaky rare side effects. Give it time.

Not all side effects have been listed here, just the most likely and most interesting. For all reported side effects, see Viibryd’s PI Sheet.



What You Really Need to be Careful About

Pregnancy Category

Viibryd’s Noted Drug-Drug, Drug-Food & Drug-Supplement Interactions

As Viibryd (vilazodone) is metabolized by CYP3A4 you should avoid:

  • grapefruit juice
  • pomegranate juice
  • Earl Grey tea
  • charbroiled (seared, blackened) meat
  • and other foods

otherwise it will be as if you’re taking more than your actual dosage.

See the Tips on Taking Crazymeds page for details about drug-food interactions involving CYP3A4/5. This includes the extra-special interaction of medications which are metabolized by CYP3A4, like Viibryd (vilazodone) is, with being obese.

Check for Other Drug-Drug, Drug-Food & Drug-Supplement Interactions Viibryd may have at

Drugs.com’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on teh Faecesbooks.
Learn more about drug-everything interactions on our page of tips about taking crazy meds.



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1 As well as being an indication of half of said conditions.


Last modified on Wed, 04 May, 2016 at 17:59:38 by JerodPoorePage Author Date created Saturday, 14 July 2012 at 13:07:53
“Viibryd (vilazodone) Pharmacology” by Jerod Poore is copyright © 2012 Jerod Poore Published online 2012/07/14

Viibryd, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Viibryd’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.



Page design and explanatory material by Jerod Poore, copyright © 2003 - 2016. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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