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‹< Viibryd’s Pharmacology |

US brand name: Viibryd
Generic name: vilazodone

Comments

I’m disappointed with Viibryd. Not from taking it, as anything like an SSRI and I don’t get along. I disappointed because this is the most boring drug on the planet. When I started studying its mechanism of action I thought it would be something really useful, even if it is essentially Paxil and BuSpar in one pill. Once I started reading people’s experiences it turns out that a Paxil and BuSpar cocktail isn’t universally effective for people who sort of respond to SSRIs. If an SSRI worked for you and later pooped out on you (tachyphylaxis), Viibryd is worth a shot. Although “pooped out” will probably take on an entirely new meaning, as you’ll probably poop out everything you eat within 10 minutes for the first few weeks. Or for as long as you take it. If SSRIs or SNRIs never worked for you, Viibryd would be a waste of time and side effects.

Viibryd supposedly has fewer sexual side effects than SSRIs. I don’t believe that, and neither does Dr. Carlat.

One thing I have noticed from reading the reviews and various experiences with Viibryd, when it does work it works really well. Viibryd isn’t hated any more than other crazy meds, like Effexor is, so it’s either going to be the best thing that ever happened to you, or it will be just another drug that didn’t work out.

Viibryd is potent. If Paxil was too much for you, don’t even think about getting near a bottle of Viibryd. The only things that keeps it from being legal LSD are being an agonist at a 5-HT receptor just to the left of the psychedelic sweet spot, and its (literally) shitty bioavailability1.

Name, Address, Serial Number (Generic and Overseas Availability)

Available in the US as a generic? No

Shapes & Sizes (How Supplied)

 Oval tablets with the dosage printed on one side. The colors are:
  • 10mg - pink tablets
  • 20mg - orange tablets
  • 40mg - blue tablets


Other Trade Names and Overseas Availability

Not including controlled/extended/sustained release suffixes (Efexor ER, Trevilor retard e.g.) or branded generics that are a hyphenate of the generic name and the drug company name (Apo-Citalopram e.g.).

Other Trade Names

ビラゾドン ( Birazodon ) - Japan

Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, and Other Sites that may be of Interest

Viibryd’s Full US Prescribing Information / PI Sheet

Official Sites

Official US Viibryd site

Rating & Review Sites



Discussion board

If you have any questions not answered here, please see the Crazymeds Viibryd discussion board.

References

  1. Viibryd’s Full US Prescribing Information
  2. Faught, Edward. “Topiramate in the treatment of partial and generalized epilepsy.” Neuropsychiatric disease and treatment 3.6 (2007): 811-821.
  3. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Fourth edition ISBN:978-1107686465 by Stephen M. Stahl © 2013 Published by Cambridge University Press.
  4. Primer of Drug Action 12th edition by Robert M. Julien Ph.D, Claire D. Advokat, Joseph Comaty © 2011 ISBN:978-1429233439 Published by Worth Publishers.
  5. Clinical Handbook of Psychotropic Drugs 20th edition Kalyna Z. Bezchlibnyk-Butler, J. Joel Jeffries, Ric M. Procyshyn, Adil S. Virani © 2014 Published by Hogrefe & Huber Publishers.
  6. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders Lee A. Dawson & Jeannette M. Watson
  7. Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone Zoe A. Hughes, et al.
  8. Thomas L. Schwartz, Umar A. Siddiqui and Stephen M. Stahl
  9. Behavioral and Neurochemical Effects of 5-{4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide (EMD 68843): A Combined Selective Inhibitor of Serotonin Reuptake and 5-Hydroxytryptamine1A Receptor Partial Agonist Michelle E. Page et al.
  10. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder Martin Paspe Cruz
  11. Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use Mandeep Singh and Thomas L Schwartz
  12. Four “New” Antidepressants. Or Are They? Jim Phelps & Daniel Carlat
  13. Viibryd’s heavily redacted NDA

‹< Viibryd’s Pharmacology |

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1 OK, at 72% Viibryd's bioavailability, and pharmacokinetics in general, really aren't all that bad. But you get that 72% bioavailability only if you take vilazodone with food. You'd be lucky to get 43% bioavailability if you took vilazodone on an empty stomach.


Last modified on Wed, 04 May, 2016 at 17:59:38 by JerodPoorePage Author Date created Saturday, 14 July 2012 at 13:07:53
“Viibryd (vilazodone): Availability, Comments, Links, More” by Jerod Poore is copyright © 2012 Jerod Poore Published online 2012/07/14

Viibryd, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Viibryd’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.



Page design and explanatory material by Jerod Poore, copyright © 2003 - 2016. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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