‹< Topamax’s Pharmacology |

US brand name: Topamax
Generic name: topiramate


Topamax is also known as Dopamax and Stupamax, and here at Crazymeds1 we coined the term “supermodel drug” for both Topamax and Zonegran, because they can make you skinny and stupid. Among the bi-polor2 it’s known as Topomax.

Topamax is also a Godsend for a lot of people with migraines and/or various forms of epilepsy, and is the first thing a lot of neurologists will prescribe. Why? Because it’s the first drug since Tegretol (carbamazepine) with FDA approval to be used by itself to treat full-on, generalized, flopping-on-the-ground seizures. While Topamax might make you skinny, in the long run more people would rather take a low dosage of Depakote than a high dosage of Topamax to control their seizures, only you can’t officially take Depakote by itself for generalized seizures. And carbamazapine can be as much of a pain in the ass to take as Depakote, hence Topamax is the first med to try for a lot of people.

I’m more than happy to put up with the frequent renal calculus (doctorese for the sediment in my piss that is more “kidney sand” and “kidney pebbles” than kidney stones), the hosed memory, the increased problems in getting the right words out of my mouth, and random periods of coffee = panic attacks so I don’t have to worry about having some kind of seizure activity a couple times a week or go through the hell that is ultradian rapid cycling.

Topamax was originally synthesized in the 1970s, and was initially developed as an oral hypoglycemic to control weight in diabetes 2. It is an inhibitor of gluconeogenesis, as such is similar to metformin. Now that it is available generically Johnson & Johnson has probably given up its 40-year-long quest to get Topamax approved as a weight-loss drug for people with diabetes. Instead they’ll leave that to Vivus, who have combined topiramate and phentermine in an obesity pill called Qnexa. Qnexa - Mayan for “You’ve got to be fracking kidding me.”

Name, Address, Serial Number (Generic and Overseas Availability)

Available in the US as a generic? Yes

Shapes & Sizes (How Supplied)

Tablets have OMN on one side and the dosage on the other. The color varies with dosage.

  • 25 mg tablet is cream
  • 50 mg tablet is light yellow
  • 100 mg tablet is yellow
  • 200 mg tablet is salmon
  • 15 and 25 mg sprinkle capsules contain small, white to off white spheres. The gelatin capsules are white and clear and printed with “TOP” and the dosage.

Other Trade Names and Overseas Availability

Not including controlled/extended/sustained release suffixes (Efexor ER, Trevilor retard e.g.) or branded generics that are a hyphenate of the generic name and the drug company name (Apo-Citalopram e.g.).

Available as Topamax in These Countries

Argentina, Australia, Brazil, EU, Ireland, New Zealand, Norway, and the UK.

Available as Generic Topiramate in These Countries

Australia, France, New Zealand

Transliterated, Overseas Trade and Branded Generic Names

  • Epitomax: France, Italy
  • Topamac: Columbia, Greece
  • Topimax: Denmark, Finland, Iceland, Norway, Sweden
  • Topiramat-Cilag: Germany
  • Topiramat-Janssen: Germany
  • Topamax migrans: Germany
  • Топамакс (Topamax): Russia
  • Topina: Japan
  • topiramaat: Dutch for topiramate
  • topiramaattia: Finnish for topiramate
  • topiramato: Spanish for topiramate
  • топирамат: Cyrillic transliteration of topiramate
  • topiramatum - Latin for topiramate3
  • Toplep: South Africa
  • Tamate: Australia
  • Epiramax: Australia
  • Topitaren: France
  • Tipiramate: France

Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, and Other Sites that may be of Interest

Topamax’s Full US Prescribing Information / PI Sheet

Official Sites

Janssen-Cilag has a buttload of sites for their products. Links to all the SPCs & PILs we could find are below. Some of the sites are good only for that, some have information about conditions, services, etc. that is useful, and some are as content-free as a lot of support group sites.

PI Sheets from Around the World

Rating and Review Sites

Other Sites of Interest

Discussion board

If you have any questions not answered here, please see the Crazymeds Topamax discussion board.


  1. the Full US Topamax PI sheet
  2. Faught, Edward. “Topiramate in the treatment of partial and generalized epilepsy.” Neuropsychiatric disease and treatment 3.6 (2007): 811-821.
  3. Stahl, Stephen M. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Third edition Cambridge University Press 2008. ISBN:978–0521673761
  4. Julien, Robert M. Ph.D, Claire D. Advokat, and Joseph Comaty Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs 12th edition Worth Publishers 2011. ISBN:978–1429233439
  5. Stahl, Stephen M. The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition Cambridge University Press 2009. ISBN:978–0521743990
  6. Virani, Adil S., K. Bezchlibnyk-Butler, and J. Jeffries Clinical Handbook of Psychotropic Drugs 18th edition Hogrefe & Huber Publishers 2009. ISBN:978–0889373693
  7. Kaufman, David Myland, MD Clinical Neurology for Psychiatrists W.B. Saunders Company 2001 ISBN:1416030743
  8. Levy, René H., Richard H. Mattson, Brian S. Meldrum, and Emilio Perucca Antiepileptic Drugs Lippincott Williams & Wilkins 2003. ISBN:0781723213
  9. Silberstein, Stephen D., Michael J. Marmura Essential Neuropharmacology: The Prescriber’s Guide Cambridge University Press 2010. ISBN:978–0521136723
  10. Kaufman, David Myland, MD Clinical Neurology for Psychiatrists W.B. Saunders Company 2001 ISBN:1416030743
  11. Epilepsy: Patient and Family Guide Orrin Devinsky
  12. PDR: Physicians’ Desk Reference 2010 64th edition
  13. Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series)
  14. Stanley I. Rapoport, Mireille Basselin, Hyung-Wook Kim, and Jagadeesh S. Rao “Bipolar disorder and mechanisms of action of mood stabilizers” Brain Research Reviews Volume 61, Issue 2, October 2009
  15. T.D. Graves “Ion channels and epilepsy” QJM: An International Journal of Medicine Volume 99, Issue 4, April 2006
  16. Pharmacokinetic Interactions of Topiramate Bialer, Meir; Doose, Dennis ; Murthy, Bindu; Curtin, Christopher; Wang, Shean-Sheng; Twyman, Roy; Schwabe, Stefan Clinical Pharmacokinetics Volume 43, Issue 12 2004
  17. Bruce E. Maryanoff “Pharmaceutical “Gold” from Neurostabilizing Agents: Topiramate and Successor Molecules” The Journal of Medical Chemistry Volume 52, Number 11. That link takes you to the entire issue, which is 166-page-long PDF delivered through an ftp port, so be prepared to wait for it. It’s a good read if you’re interested in the history of Topamax and medications for diabetes.
  18. Steffen Naegel and Mark Obermann “Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference”
  19. Topiramate for Migraine Prevention: A Randomized Controlled Trial
  20. Pierre M Joubert, MB ChB, FCPsych, MMed (Psych) (SA) “Psychiatric uses of topiramate: What is the current evidence?”
  21. “Topiramate in the Treatment of Epilepsy – A Review”
  22. “Psychopharmacology of topiramate: from epilepsy to bipolar disorder”
  23. “Open-Label Adjunctive Topiramate in the Treatment of Bipolar Disorders”
  24. “The Stanley Foundation Bipolar Network 2. Preliminary summary of demographics, course of illness and response to novel treatments”
  25. “The New Antiepileptic Drugs”
  26. Cecilie Johannessen Landmark “Targets for antiepileptic drugs in the synapse” Medical Science Monitor Volume 13, Issue 1, January 2007
  27. Tomaž Vovk, Mihajlo B. Jakovljević, Mojca Kerec Kos, Slobodan M. Janković, Aleš Mrhar, and Iztok Grabnar “A Nonlinear Mixed Effects Modelling Analysis of Topiramate Pharmacokinetics in Patients with Epilepsy” Biological & Pharmaceutical Bulletin Volume 33, Number 7, March 2010

‹< Topamax’s Pharmacology |

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1 OK, I came up with the term "supermodel drug" in 2002 and first used it over at bipolar.about.com It started showing up all over teh Intergoogles in 2004, shortly after Crazymeds came into existence.

2 My rant about how bipolar is spelled is in a footnote for this site's homepage.

3 For what, the Vatican City Walgreens? Pedantic snobbery? Why the holy fuck do you need an INN in fucking Latin?

Last modified on Wed, 04 May, 2016 at 16:18:15 by JerodPoorePage Author Date created Tuesday, 11 January 2011 at 13:43:23
“Topamax (topiramate): Availability, Comments, Links, More” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/01/11

Topamax, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Topamax’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

Page design and explanatory material by Jerod Poore, copyright © 2003 - 2016. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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