|US brand name: Savella|
|Generic name: milnacipran|
Savella’s Pros and Cons
- Savella / Ixel affects norepinephrine much more than serotonin, which is important for people whose problems are addressed by tweaking norepinephrine more than serotonin.
- When it works, it really works.
- Savella / Ixel still has a significant affect on serotonin, which messes with a lot of us. We still have only Strattera, reboxetine, and a couple TCAs like desipramine for norepinephrine-only (or mostly) reuptake inhibition.
- Only works for about 25% of the people who take it.
Interesting Stuff your Doctor Probably didn’t Tell You about Savella
- Your doctor had damn well better tell you about getting regular blood tests to make sure your liver isn’t imploding. What makes it interesting is there doesn’t seem to be a good reason why. Your liver barely does anything with milnacipran.
- Savella / Ixel and its sister drug Fetzima (levomilnacipran) are the only SNRIs that are like most TCAs, in that they work on norepinephrine significantly more than serotonin.
- In June 2000 Toledomin was the first SNRI to be approved in Japan. Which is probably interesting only to me and the 2 or 3 other people in the overlapping sets of pharmacology nerds and Nipponophiles.
Best Known for
The med whose side effects suck more than fibromyalgia. That’s a neat trick.