« Savella’s Side Effects, Warnings, etc. | Savella’s Pharmacology »

US brand name: Savella
Generic name: milnacipran

Savella’s Pros and Cons


  • Savella / Ixel affects norepinephrine much more than serotonin, which is important for people whose problems are addressed by tweaking norepinephrine more than serotonin.
  • When it works, it really works.


Interesting Stuff your Doctor Probably didn’t Tell You about Savella

  • Your doctor had damn well better tell you about getting regular blood tests to make sure your liver isn’t imploding. What makes it interesting is there doesn’t seem to be a good reason why. Your liver barely does anything with milnacipran.
  • Savella / Ixel and its sister drug Fetzima (levomilnacipran) are the only SNRIs that are like most TCAs, in that they work on norepinephrine significantly more than serotonin.
  • In June 2000 Toledomin was the first SNRI to be approved in Japan. Which is probably interesting only to me and the 2 or 3 other people in the overlapping sets of pharmacology nerds and Nipponophiles.

Best Known for

The med whose side effects suck more than fibromyalgia. That’s a neat trick.

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« Savella’s Side Effects, Warnings, etc. | Savella’s Pharmacology »

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Last modified on Wed, 04 May, 2016 at 17:17:56 by JerodPoorePage Author Date created Saturday, 04 October 2014 at 17:55:01
“Savella (milnacipran): Pros and Cons” by Jerod Poore is copyright © 2014 Jerod Poore Published online 2014/10/05

Savella, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Savella’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

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