Highlighting side effects, warnings, interactions, and more

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US brand name: Neurontin
Generic name: gabapentin

Neurontin’s Potential Side Effects

Potential Side Effects All Crazy Meds Have

No matter which neurological and/or psychiatric drug you take, you’ll probably get one or more of these side effects. These will usually be gone, or at least will diminish to the point where you barely notice it most of the time, within a week or two.

  • Headache
  • Drowsiness / fatigue - even when taking stimulants in some circumstances.
  • Insomnia, instead of or alternating with the drowsiness.
  • Nausea
  • Assorted other minor GI complaints (constipation, diarrhea, etc.)
  • Generally feeling spacey / out of it
    • Which can all add up to the ever-helpful “flu-like symptoms” listed as an adverse event on the PI sheet of practically every medication on the planet used to treat almost any condition humans and other animals could have.1
  • All crazy meds can, and probably will affect your dreams as well. There is no way of telling if that will be good or bad, let alone if this side effect is permanent or temporary.
  • Any of the above side effects you see listed again below means they’re even more likely to happen and/or stick around longer and/or are worse than most other meds.


Typical Potential Side Effects

The usual for Antiepileptic drugs, albeit to a lesser degree for most people. Although at the higher dosages Mouse and I, especially Mouse, experienced memory problems. The main problems with Neurontin are dizziness, cloudy thinking, fatigue and klutziness.

Uncommon Potential Side Effects

Edema. Really goofy thinking - hence the nickname “Morontin.” If being treated for bipolar disorder, don’t be surprised if it results in hypomania instead of working as a mood stabilizer - as that has been reported in the clinical trials for epilepsy, in at least one of the studies on Neurontin (gabapentin) as a treatment for bipolar, and several times in the online support groups.

Freaky Rare Side Effects

Taste perversion, abnormal accommodation, libido increased, baby you are coming over to my house right now! I’ve got plenty of Neurontin on hand!

Not all side effects have been listed here, just the most likely and most interesting. For all reported side effects, see Neurontin’s PI Sheet.



What You Really Need to be Careful About

Operating heavy machinery. Really. Impaired thinking and loss of coordination are potential side effects that sometimes don’t go away, so you may not be able to drive a car or a Zamboni while taking Neurontin.

Pregnancy Category

C-Use with caution

Neurontin’s Noted Drug-Drug, Drug-Food & Drug-Supplement Interactions

  • Magnesium-based antacids such as Maalox. Even Magnesium supplements can interfere with absorbing Neurontin.
  • Morphine and hydrocodone. They’re weird and depend on which order you take each. If you need or are already taking Neurontin and an opioid for pain there’s no way you’re going to understand this, but here it is:

Hydrocodone: Coadministration of Neurontin (125 to 500 mg; N=48) decreases hydrocodone (10 mg; N=50) Cmax and AUC values in a dose-dependent manner relative to administration of hydrocodone alone; Cmax and AUC values are 3% to 4% lower, respectively, after administration of 125 mg Neurontin and 21% to 22% lower, respectively, after administration of 500 mg Neurontin. The mechanism for this interaction is unknown. Hydrocodone increases gabapentin AUC values by 14%. The magnitude of interaction at other doses is not known.

Morphine: A literature article reported that when a 60-mg controlled-release morphine capsule was administered 2 hours prior to a 600-mg Neurontin capsule (N=12), mean gabapentin AUC increased by 44% compared to gabapentin administered without morphine (see PRECAUTIONS). Morphine pharmacokinetic parameter values were not affected by administration of Neurontin 2 hours after morphine. The magnitude of interaction at other doses is not known. Neurontin PI sheet

Check for Other Drug-Drug, Drug-Food & Drug-Supplement Interactions Neurontin may have at

Drugs.com’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on teh Faecesbooks.
Learn more about drug-everything interactions on our page of tips about taking crazy meds.



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1 As well as being an indication of half of said conditions.


Last modified on Wed, 04 May, 2016 at 17:28:57 by JerodPoorePage Author Date created Mon, 25 Apr, 2011
“Neurontin (gabapentin) Pharmacology” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/04/25

Neurontin, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Neurontin’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.



Page design and explanatory material by Jerod Poore, copyright © 2003 - 2016. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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