« Neurontin’s Side Effects, Warnings, etc. | Neurontin’s Pharmacology »

US brand name: Neurontin
Generic name: gabapentin

Neurontin’s Pros and Cons


  • It has a very low side effect profile.
  • Few drug-drug interactions. Neurontin (gabapentin) is a proven pain reliever that doesn’t mess with you as much as the other anticonvulsants do, and works better for non-migraine pain better than most of the others.


It doesn’t work for a lot of people, mostly because of bioavailability issues. Because of Parke-Davis’ allegedly sleazy marketing practices you probably can’t get samples from your doctor anymore.

Interesting Stuff your Doctor Probably didn’t Tell You about Neurontin

The interesting thing doctors and pharmacists should never skip is you can’t exchange Neurontin and Horizant at a 1:1 ratio. I don’t think I’ll be able to figure out a schedule. Why? This is why:

As dose is increased, bioavailability decreases. Bioavailability of gabapentin is approximately 60%, 47%, 34%, 33%, and 27% following 900, 1200, 2400, 3600, and 4800 mg/day given in 3 divided doses, respectively. Neurontin PI sheet

You can try to squeeze out a little more absorption by taking it with food, but you buy a whopping 14% increase, on average, in the bioavailability. Sometimes every little bit helps.

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« Neurontin’s Side Effects, Warnings, etc. | Neurontin’s Pharmacology »

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Last modified on Wed, 04 May, 2016 at 17:28:57 by JerodPoorePage Author Date created Mon, 25 Apr, 2011
“Neurontin (gabapentin): Pros and Cons” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/04/25

Neurontin, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Neurontin’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

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