Highlighting side effects, warnings, interactions, and more


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US brand name: Lexapro
Generic name: escitalopram

Lexapro’s Potential Side Effects

Potential Side Effects All Crazy Meds Have

No matter which neurological and/or psychiatric drug you take, you’ll probably get one or more of these side effects. These will usually be gone, or at least will diminish to the point where you barely notice it most of the time, within a week or two.

  • Headache
  • Drowsiness / fatigue - even when taking stimulants in some circumstances.
  • Insomnia, instead of or alternating with the drowsiness.
  • Nausea
  • Assorted other minor GI complaints (constipation, diarrhea, etc.)
  • Generally feeling spacey / out of it
    • Which can all add up to the ever-helpful “flu-like symptoms” listed as an adverse event on the PI sheet of practically every medication on the planet used to treat almost any condition humans and other animals could have.1
  • All crazy meds can, and probably will affect your dreams as well. There is no way of telling if that will be good or bad, let alone if this side effect is permanent or temporary.
  • Any of the above side effects you see listed again below means they’re even more likely to happen and/or stick around longer and/or are worse than most other meds.

Typical Potential Side Effects

The usual for SSRIs - headache, nausea, dry mouth, sweating, sleepiness or insomnia (with insomnia more likely), constipation weight gain and assorted sex problems.

Weight gain is a lot less likely than with other SSRIs and all of the typical side effects tend to be milder. The most likely sexual side effect is anorgasmia, i.e. you can’t come, no matter how much romance and/or porn is involved. In the prudish language of PI sheets and clinical trials, anorgasmia affects only women. With men the problem is listed as an “ejaculation disorder.”

Uncommon Potential Side Effects

SSRI-Induced Indifference / Apathy. Teeth grinding (bruxism). Yawning, jaw tightening and clenching to the point of temporomandibular joint syndrome (TMJ) and a dental specialist’s intervention (e.g. wearing a mouth guard at night).

Freaky Rare Side Effects

Sexsomnia (I wish I could read Dutch), labial pigmentation and lichenoid eruption, and atypical jitteriness syndrome (which reads like a Prescott Pharmaceuticals product side effect).

Not all side effects have been listed here, just the most likely and most interesting. For all reported side effects, see Lexapro’s PI Sheet.

What You Really Need to be Careful About

Heart arrhythmia problems like torsades de pointes (TdP)/prolonged QT interval (QTc). This happens more often than I had originally thought, as both Celexa (citalopram) and Lexapro (escitalopram) are on the list of drugs to totally avoid if you have a history of TdP/QTc/cardiac arrhythmia.

Pregnancy Category

C-Use with caution

Lexapro’s Noted Drug-Drug, Drug-Food & Drug-Supplement Interactions

Check for Other Drug-Drug, Drug-Food & Drug-Supplement Interactions Lexapro may have at

Drugs.com’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on teh Faecesbooks.
Learn more about drug-everything interactions on our page of tips about taking crazy meds.

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« Lexapro’s Uses and Using | Lexapro’s Pros and Cons »

Pages and Forum Topics Google Thinks are Relevant to Your Mental Health

1 As well as being an indication of half of said conditions.

Last modified on Wed, 04 May, 2016 at 16:45:52 by JerodPoorePage Author Date created Sunday, 05 December 2010 at 13:49
“Lexapro (escitalopram) Pharmacology” by Jerod Poore is copyright © 2010 Jerod Poore Published online 2010/12/05

Lexapro, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Lexapro’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

Page design and explanatory material by Jerod Poore, copyright © 2003 - 2016. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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