how long until Abilify starts to work, likelihood Abilify will work for your condition, and Abilify vs. other Antipsychotics

> How Long Until Abilify Works

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Approved & Off-label Uses | Abilify Index | How to Take and Discontinue
Return to the Abilify Page

Comparatively Effective

Two of the most important things to know when deciding on which med is the best for a particular condition1: how likely is it to work and how long will it take.

The odds of a med working for a particular condition and how long it generally takes to work should be fairly easy to nail down, and not need to be summed up by the Internet shorthand YMMV (Your Mileage May Vary). Aside from it being hard enough to get an accurate diagnosis when brain cooties are involved, why is it so difficult to figure out if Abilify (aripiprazole) is right for you and how long it will take for you to know that?

  • Because no one is quite sure exactly what causes various conditions.
  • Which is further complicated when everything is a spectrum disorder (e.g. bipolar 1, bipolar 2, all the others they still ignored in DSM-5).
  • And they’re never really sure about how Abilify works in the first place.
  • Plus, if you have more than one condition for which you’re taking one or more medications to treat, things get really complicated.
  • None of which is helped by studies that produce contradictory results and other quirks in The Literature.

Always remember: if your symptoms suddenly get a lot worse, call your doctor immediately. Any drug that makes your symptoms worse is a drug you probably need to stop taking as soon as possible.

We reference a shitload of studies here, so you might want to see our pages on how to deal if a study is legitimate and the tests and methodologies researchers use to measure the efficacy of medications, including during clinical trials to get FDA approval.

How Long Until Abilify (aripiprazole) Starts Working

Faster than Seroquel, but slower than most other AAPs. I.e. 3–7 days, with 3 days more likely when adding Abilify to an AD and 7 days more likely when using Abilify by itself.

How Effective Abilify (aripiprazole) is for its Approved Uses

Given its activating nature, Abilify is probably more likely to work as an add-on to treat depression or bipolar disorder than as monotherapy for bipolar disorder. I don’t yet have enough data for schizophrenia, other than 5mg a day takes 3-5 weeks to start working, and only enough better than placebo to get approved by the FDA.

OK, I have a little more data than that, but it’s still mostly from books and studies. I like having more anecdotal evidence.

Likelihood Abilify (aripiprazole) will Work for Off-Label Applications

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Abilify (aripiprazole) versus Other Antipsychotics for its Approved Indications

Bipolar Disorder

  • Abilify vs. Haldol (haloperidol) vs. Placebo for bipolar mania. This is one of the European clinical trials, so it was paid for by Bristol-Myers Squibb (BMS) and Otsuka Pharmaceuticals, the manufacturers of Abilify. Haldol? OK, they were looking only at mania, so Haldol qualifies as an active placebo. The results: A tie! Wait, what? Yup, Haldol was marginally more effective, but Abilify sucked somewhat less.

Schizophrenia

  • Abilify vs. Risperdal vs. Placebo for schizophrenia & schizoaffective disorders. This is another BMS & Otsuka-sponsored study, so you know Abilify is going to win. The results: A tie! Even with one hand tied behind its back, Risperdal was just as good as Abilify. Abilify was better for negative symptoms and Risperdal was better for positive symptoms. Abilify sucked a lot less for the big-ticket side effects of weight gain, hyperprolactinemia-associated adverse reactions (porno boobs, leaky tits, sexual dysfunction, etc.), and QT interval, but Risperdal is easier to keep down. Oddly enough movement disorders were identical, but this was high-dosage Abilify (20–30mg) vs. low target dosage (for schizophrenia) (6mg) Risperdal.
  • Abiliby vs. Risperdal or Seroquel or Zyprexa: which makes you less crazy while still letting you fuck like a crazed otter? This is an expanded look at the data from one of the European clinical trials, so it’s BMS & Otsuka-sponsored study, and you have to expect Abilify going to win. They just lumped the competition into one group, so there’s no way to tell how each of the other meds worked. The results: Abilify worked better and sucked a lot less, especially when it came to sex. Why am I not surprised?
  • Abilify vs. Zyprexa which one works better and sucks less when treating schizophrenia. This is an Eli Lily-sponsored clinical trial that taught me the official research name of which sucks less: “all cause discontinuation.” The results: In spite of the weight gain Zyprexa wins. Anyone surprised? That Zyprexa works better and faster is to be expected, even in a trial run by a neutral party, but when Abilify has an affect on weight, glucose, and triglycerides that make it look like a diabetes treatment, you’ve got to wonder about why so many people dropped it.

How Abilify (aripiprazole) Compares with Other Drugs for Off-Label Treatments

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References

Approved & Off-label Uses | Abilify Index | How to Take and Discontinue


1 Assuming you were correctly diagnosed in the first place.


If you have any questions not answered here, please see the Crazymeds Abilify discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)


Last modified on Tuesday, 08 July, 2014 at 18:51:12 by JerodPoorePage Author Date created Tuesday, 29 November 2011 at 11:57:45
“Abilify (aripiprazole): a Review for the Educated Consumer.” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/11/29
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Abilify, and all other drug names on this page and used throughout the site, are a trademark of someone else. Abilify’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.




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All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
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All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList, NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.

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