|US brand name: Effexor|
|Generic name: venlafaxine|
Effexor’s Pros and Cons
- For deep, despairing, clinical depression that will only respond to the standard tweaking of at least two out of the three most popular neurotransmitters1, Effexor often pulls people out of the abyss when SSIs, other SNRIs, Wellbutrin, and TCAs have failed.
- Because Effexor works on more than one neurotransmitter, it is far less likely to poop-out than an SSRI.
- For many people Effexor has the absolute worst discontinuation syndrome of any antidepressant.
- It is a medication people utterly loathe to have taken.
- It is not uncommon for someone to fire their doctor during or immediately after they quit taking Effexor because the discontinuation syndrome can be that bad.
Interesting Stuff your Doctor Probably didn’t Tell You about Effexor
Raw, freebase2 venlafaxine is actually one of, if not the least potent of all the antidepressants on the market.
If venlafaxine hydrochloride weren’t so well absorbed and distributed Let’s see if I can write it down correctly this time. If the active ingredient were as well-absorbed and distributed when compared with the other ADs I could understand why it is so effective. As it is, I can’t understand why the hell it isn’t be practically a placebo.
I was right the first time. ULD is just kicking my ass some days. Venlafaxine HCl’s truly awesome pharmacokinetics are why such a weak-ass drug is so effective. They may also have something to do with why the discontinuation syndrome sucks so much donkey dong, but that’s still just a guess of mine and there’s no research to back it up. Just like Paxil, the short half-lives of venlafaxine HCl and its active metabolite are a known reason why Effexor withdrawal sucks so much shit. And why some people experience SSRI/SNRI discontinuation syndrome if they miss a single dose, or are a few hours late in taking a dose!
It could be that it’s like bupropion, another weak-as-water3 drug that is surprisingly effective. According to Dr. Stahl, bupropion might be transformed into one or more of its three (so far known) active metabolites by the CYP450 genes in your brain instead of in your liver. So what it doesn’t have in the way of raw, pharmacological power, it makes up for by being undiluted by plasma. As venlafaxine is also converted does the same thing.
Best Known for
The discontinuation syndrome from hell.