|US brand name: Depacon|
|Generic name: sodium valproate|
side effects, dosage, how to take & discontinue, uses, pros & cons, and more
Table of Contents (hide)
- 1. FDA Approved Uses of Depacon (valproate sodium)
- 2. Approved Uses of Sodium Valproate (Epilim, Orlept, etc.) in Other Countries
- 3. Off-Label Uses of Depacon (valproate sodium)
- 4. Off-Label Uses of Sodium Valproate
- 5. Sodium Valproate Pros and Cons
- 6. Side Effects
- 7. Interesting Stuff Your Doctor Probably Won’t Tell You
- 8. Depacon (valproate sodium) Dosage and How to Take Depacon (valproate sodium)
- 9. Sodium Valproate Dosage and How to Take Sodium Valproate
- 10. How Long Depacon (valproate sodium) Takes to Work
- 11. How Long Sodium Valproate Takes to Work
- 12. How to Stop Taking Depacon (valproate sodium)
- 13. How to Stop Taking Depacon (valproate sodium)
- 14. How to Stop Taking Sodium Valproate
- 15. Depacon (valproate sodium) Half-Life & Average Time to Clear Out of Your System
- 16. Days to Reach a Steady State
- 17. Shelf life
- 18. Comments
- 19. Other brand names & branded generic names1
- 20. Depacon Ratings, Reviews, & Other Sites of Interest
- 21. References
Other Forms: Available in the US only as an intravenous injection. Elsewhere in the world sodium valproate is available as immediate-release and extended-release tablets, syrup, liquid, and injection. In a syrup it’s natrium valproate.
The same as Depakene (valproic acid)…
- Monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures.
- Monotherapy and adjunctive therapy in the treatment of simple and complex absence seizures.
- Adjunctive therapy in patients with multiple seizure types which include absence seizures.
…but only if you are unable to swallow a pill.
It all depends on which country you happen to be in. While sodium valproate is only an ingredient of Depakote, outside of North American it is Depakote. Especially since Depakote has gone off-patent and is now showing up in other countries under the same brand names as sodium valproate, but as an extended-release formulation. Let the confusion get even worse! In any event is approved to treat:
- All forms of epilepsy, by itself or with other meds (Pretty much everywhere in the world).
- Bipolar disorder (not as universal as epilepsy).
- Migraines (practically nowhere).
- Migraines in emergency rooms. Depacon is getting a lot of use treating non-responsive headaches bad enough to send someone to the hospital.
- Treatment of everything Depakote and Stavzor treat when someone can’t take their pills. I.e. migraines and bipolar disorder.
- Status epilepticus.
- Treating migraines or bipolar disorder if it’s not approved to do so in whatever country you’re in.
- status epilepticus.
Proven effective for wide spectra of epilepsies and bipolar disorders. It’s been around for so long that the long-term effects are well known and well documented. If you can get past the initial side effects and get used to a valproate medication, you don’t have to worry about anything biting your ass in the long run. In that your doctor should know all the potentially serious bad shit that can happen, like liver failure, and how to prevent it, like making you get a liver function test between one and four times a year2.
The side effects suck donkey dong! The valproates are amongst the harshest meds to take. Everyone (read: the bipolar) hates them so much that they’ve given the entire class of AEDs/anticonvulsants a bad name.
The usual for SSRIs - headache, nausea, dry mouth, sweating, sleepiness or insomnia, and diarrhea or constipation, weight gain, loss of libido. Most everything will go away after a week or two, but the weight gain and loss of libido might stick around longer. Or permanently.
Twitching, ‘flu-like symptoms, abnormal periods.
Bedwetting, reversible dementia and reversible Parkinson’s. I told you you’d get instantly old.
- Taking valproates with food helps reduce a lot of the gastrointestinal problems.
- Sodium valproate interacts with aspirin. Aspirin prevents you from metabolizing valproates properly, so you’re better off with Aleve (naproxen sodium) or Tylenol (acetaminophen). Ibuprofen is OK, but only if you’re taking no more than 400mg a day. While there is no documented interaction, and , I’d be too freaking paranoid to take Tylenol and a valproate at the same time for more than a couple of days.
- Your doctor had better damn well be telling you about the regular blood work you need, to check your valproate levels and to make sure your liver is functioning normally.
- Valproates can sap your body of vitamin D, folic acid, and maybe even calcium. So ask your doctor about tests for vitamin D and calcium levels and supplements. You should probably take 400–1,000mcg of folic acid in any event, but no more than that, otherwise it might interfere with how well sodium valproate works. That folic acid may help you feel a lot less lethargic.
I Forgot Why I Cake Topamax
In the US Depacon is approved to treat what Depakene is approved to treat, and you’re only supposed to be given Depacon if you’re unable to swallow your pills. It’s a one-to-one replacement that requires a professional. It’s all spelled out .
Dosage and dosing schedule, like the approval, can depend on where you live. The consensus in the English-speaking world is:
Start at 600mg a day and increase by 200mg a day every three days, as required, until seizure control is reached. The dosage range is typically 1,000mg - 2,000mg a day, with a maximum dosage of 2,500mg a day.
Start at 600mg a day, increase to 800mg at day two, then increase by 200mg every three days until you stop bouncing off the ceiling.
Since you’d probably be taking it if you’re in the hospital when you can’t take your regular meds, it’s a moot point. Or if it’s an off-label use in the ER, Depacon either works immediately or not at all.
In theory you should start feeling results once you’re in the therapeutic range of your blood levels, but other countries don’t seem all that interested in blood levels. Your guess is as good as mine.
Don’t worry about it. You’ll either be back on your regular med, or you needed only one or two doses.
Slowly. With most crazy meds we suggest that you reduce your dosage by however much you increased it, but with the rapid loading dose method that is often used for severe mania, that’s not always such a good idea.
As with Abbott the only discontinuation instructions Sanofi supplied are “be freaking careful.” Our suggestion to talk to your doctor about is to reduce your dosage by 200mg a day every five to seven days. I can’t do much more than that. Sorry.
For more information, please see the page on how to safely stop taking these crazy meds.
Half-life: 8–12 hours hours. It’s out of your system in 2–3 days.
Valproate sodium’s non-linear. You can’t pin down a hard number on it. I haven’t found a number for it in any study. Based on the usual formula of 6 * half-life, approximately three days.
- Tablets (overseas): 3 years.
- IV infusion: 5 years in the vial, 1 day after it’s prepped for use.
19. Other brand names & branded generic names1
- Convulex (Germany), Convulex Syrup (South Africa)
- Depakene (Japan)
- Depakin (Bulgaria; Turkey)
- Depakine (Austria; Bahrain; Belgium; Cyprus; Egypt; France; Greece; Hungary; Iran; Iraq; Jordan; Korea; Kuwait; Lebanon; Libya; Netherlands; Oman; Portugal; Qatar; Republic of Yemen; Saudi Arabia; Spain; Switzerland; Syria; Thailand; United Arab Emirates)
- Depakine Chrono (Belgium; Hungary; Poland; Portugal; Taiwan; Thailand)
- Depakine Druppels (Netherlands)
- Depakote (France)
- Depalept (Israel)
- Epilam (Korea)
- Epilex (Turkey)
- Epilim (Australia; Bahamas; Barbados; Belize; Benin; Bermuda; Burkina Faso; China; Curacao; Ethiopia; Gambia; Ghana; Guinea; Guyana; Hong Kong; Ireland; Ivory Coast; Jamaica; Kenya; Kuwait; Liberia; Libya Lebanon; Malawi; Malaysia; Mali; Mauritania; Mauritius; Morocco; Dutch Antilles; New Zealand; Niger; Nigeria; Oman; Qatar; Republic of Yemen; Saudi Arabia; Senegal; Seychelles; Sierra Leone; South Africa; Sudan; Surinam; Syria; Tanzania; Trinidad; Tunisia; Uganda; United Arab Emirates; United Kingdom; Zambia; Zimbabwe)
- Epilim Chrono (Malaysia)
- Epival (Bahrain; Costa Rica; Cyprus; Dominican Republic; Egypt; El Salvador; Guatemala; Honduras; Iran; Iraq; Jordan; Kuwait; Lebanon; Libya; Nicaragua; Oman; Panama; Qatar; Republic of Yemen; Saudi Arabia; Syria; United Arab Emirates)
- Leptilan (Bahamas; Barbados; Belize; Benin; Bermuda; Burkina Faso; Curacao; Ecuador; Ethiopia; Gambia; Ghana; Guinea; Guyana; Indonesia; Ivory Coast; Jamaica; Kenya; Kuwait; Liberia; Libya Lebanon; Malawi; Malaysia; Mali; Mauritania; Mauritius; Mexico; Morocco; Dutch Antilles; Niger; Nigeria; Oman; Qatar; Republic of Yemen; Saudi Arabia; Senegal; Seychelles; Sierra Leone; Sudan; Surinam; Syria; Taiwan; Tanzania; Trinidad; Tunisia; Uganda; United Arab Emirates; Zambia; Zimbabwe)
- Orfil (Korea)
- Orfiril (Hong Kong; Israel; Peru)
- Orfiril Retard (Singapore)
- Petilin (Bahamas; Bahrain; Barbados; Belize; Benin; Bermuda; Burkina Faso; Curacao; Cyprus; Egypt; Ethiopia; Gambia; Ghana; Guinea; Guyana; Iran; Iraq; Ivory Coast; Jamaica; Jordan; Kenya; Kuwait; Kuwait; Lebanon; Liberia; Libya; Libya Lebanon; Malawi; Mali; Mauritania; Mauritius; Morocco; Dutch Antilles; Niger; Nigeria; Oman; Oman; Qatar; Republic of Yemen; Republic of Yemen; Saudi Arabia; Saudi Arabia; Senegal; Seychelles; Sierra Leone; Sudan; Surinam; Syria; Syria; Tanzania; Trinidad; Tunisia; Uganda; United Arab Emirates; United Arab Emirates; Zambia; Zimbabwe)
- Valcote (Ecuador)
- Valeptol (Korea)
- Valoin (Korea)
- Valpakine (Costa Rica; Dominican Republic; Ecuador; El Salvador; Guatemala; Honduras; Peru)
- Valparin (Thailand)
- Valporal (Israel)
- Valprax (Peru)
- Valpro (Australia; Hong Kong)
- valproate sodium - is Abbott’s preferred generic name. The rest of the world uses sodium valproate.
- Valsup (Colombia)
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20.3 Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, check for drug-drug interactions
It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.
If you have any questions not answered here, please see the Crazymeds Depacon discussion board.
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PDR: Physicians’ Desk Reference 2010 64th edition
Instant Psychopharmacology 2nd Edition Ronald J. Diamond M.D. © 2002. Published by W.W. Norton
The Complete Guide to Psychiatric Drugs Edward Drummond, M.D. © 2000. Published by John Wiley & Sons, Inc.
Partial Seizure Disorders Mitzi Waltz © 2001. Published by O’Reilly & Associates.
Healing Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, M.D. © 2003. Published by G.P. Putnam’s Sons.
Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series) © 2007 An imprint of Elsevier.
The Bipolar Disorder Survival Guide David J. Miklowitz, Ph.D © 2002. Published by The Guilford Press.1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.
2 The vast majority of liver problems show up in the first 6 to 12 months of use, especially in the bipolar, as we usually get the most aggressive titration schedules (in English: the highest dosages the fastest) and our livers are often fucked-up to start with thanks to mania-inspired hepatitis, cirrhosis, and other problems. For most people an annual liver function test is more than enough. For anyone who takes a high dosage of a valproate, smokes, takes other medications (regardless of what they treat) that induce CYP or UGT enzymes, drinks alcohol, or eats a lot of charbroiled meat (I'm not joking), more than one liver function panel and an annual complete blood count would be a good idea.
3 Thank you! I'll be here at least 72 hours. Be sure to tip your content provider. And don't try the veal, it's cruelicious!
If you have any questions not answered here, please see the Crazymeds Depacon discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)
|Last modified on Wednesday, 04 May, 2016 at 17:04:07 by JerodPoore||Page Author Jerod Poore||Date created|
|“Depacon (sodium valproate): a Review for the Educated Consumer.” by Jerod Poore is copyright © Jerod Poore||Published online 2012/07/10|
|Citation options to copy & paste into your article:|
|Plain text:||Poore, Jerod. “Depacon (sodium valproate): a Review for the Educated Consumer.” Crazymeds (crazymeds.us). ().|
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Almost all of the material on this site is by Jerod Poore and is copyright © 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, and 2016 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.
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All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList,
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Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.
* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.