Brand & Generic Names; Drug Classes
|US brand name: BuSpar|
|Generic name: buspirone|
|Primary drug class: Anxiolytics/Anti-anxiety|
|Additional drug class(es):|
Approved & Off-Label Uses (Indications)
BuSpar’s US FDA Approved Treatment(s)
Generalized Anxiety Disorder (GAD)
Uses Approved Overseas but not in the US
Off-Label Uses of BuSpar
- Other anxiety disorders
- Smoking cessation
- Depression, along with other meds (adjunctive therapy)
When & If BuSpar Will Work
BuSpar’s Usual Onset of Action (when it starts working)
Because of the nonlinear pharmacokinetics, it’s hard to know when you should get an effect from BuSpar, but Bristol-Myers seems to think two to three days should be sufficient. Like most things that work on your serotonin, especially as this is likely to augment an antidepressant, I would make that two to three weeks to decide if BuSpar helping at all.
Likelihood of Working
BuSpar seems to be immensely variable in how it hits people — even studies showing its effectiveness noticed this. Like most meds, it’s all a matter of hitting the right neurotransmitters in the right ways. But since it’s low on the side effects and non-addictive, it’s worth a stop on the med-go-round if you’re experiencing SSRI poop-out or inadequate relief of anxiety disorders with an SSRI.
Taking and Discontinuing
How to Take BuSpar
The starting dose is usually 5 mg 3 times per day , for a total of 15 per day. With a half life of 3 hours, stepping up every two to three days is not unreasonable biologically — however, it’s insane from a common-sense point of view. Give BuSpar a week between dose step-ups at least, so you can see if it’s doing anything for you at the lower dose. Standard dosages of BuSpar in clinical trials are usually 20 to 30 mg per day; the maximum dosage of BuSpar is 60 mg per day.
How to Stop Taking BuSpar (discontinuation / withdrawal)
Given a half-live of two to three hours, stepping down by 5 mg at every day is reasonable. Though every other day would be safer. Unless it didn’t do anything at all, including no psychiatric effects, including stuff like making the anxiety or depression worse. In which case go for 10mg a day.