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US brand name: Asendin
Generic name: amoxapine

Asendin’s Pros and Cons


Amoxapine has been around since forever, so doctors are familiar with its uses and effects. Like most tetracyclics It starts to work very quickly. As it’s practically a combination antidepressant & antipsychotic it could be just the thing for anyone with treatment-resistant depression as well as psychotic, agitated and/or delusional depressions. And since it’s available only as a generic amoxapine is probably the cheapest antidepressant & antipsychotic on the market.


Amoxapine has been since forever, so younger doctors are less likely to prescribe it and other tri/tetracyclics, even if they might be a better first or second choice for you. The chances for movement- and prolactin-related side effects are less than Risperdal’s Risperdal’s but greater than a lot of other AAPs. It’s not really an antidepressant & antipsychotic cocktail so you can’t easily mix and match a replacement. Who knows how much longer it will be available in the US as it’s been pulled from the UK and New Zealand since I wrote the original article in 2004.

Interesting Stuff your Doctor Probably didn’t Tell You about Asendin

  • If you overdose on amoxapine and aspirin at the same time they can extract the novel compound, N-acetylated amoxapine, from various parts of you. What it’s good for, if anything, has yet to be determined.
  • They found out amoxapine is an antipsychotic of sorts because of so many people getting hit by the same side effects typical of APs. So crappy side effects aren’t always a bad thing. For other people.

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Last modified on Wed, 04 May, 2016 at 16:40:49 by JerodPoorePage Author Date created Monday, 28 January 2013 at 15:05:38
“Asendin (amoxapine): Pros and Cons” by Jerod Poore is copyright © 2013 Jerod Poore Published online 2013/01/28

Asendin, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Asendin’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

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