Brand & Generic Names; Drug Classes
|US brand name: Asendin|
|Generic name: amoxapine|
|Primary drug class: Antidepressants|
|Additional drug class(es): Antipsychotics, Tricyclic & Tetracyclic Antidepressants|
Approved & Off-Label Uses (Indications)
Asendin’s US FDA Approved Treatment(s)
Neurotic or reactive depressive disorders
Uses Approved Overseas but not in the US
Endogenous and psychotic depressions
Off-Label Uses of Asendin
Schizophrenia (One of numerous studies on this use)
When & If Asendin Will Work
Asendin’s Usual Onset of Action (when it starts working)
One to two weeks. Tetracyclics are fast. You’ll feel something within a couple of days.
Likelihood of Working
Taking and Discontinuing
How to Take Asendin
The initial dose is 50mg two to three times daily. After two to three weeks that may be increased to 100mg two to three times daily. Presuming this stuff works, the maintenance dose of 200–300mg may then be taken all at once at bedtime, but anything above 300mg a day needs to be split into two, or even three doses a day.
Inpatients may receive up to 600mg a day.
Given the incidence of AP-related side effects, you and your doctor should seriously discuss any increase above 200mg a day. You’d probably know by then if it’s going to be doing something positive for you.
How to Stop Taking Asendin (discontinuation / withdrawal)
Tri/tetracyclics don’t have much of a discontinuation syndrome. Depending on why you need to stop taking it, reducing your dosage by 50–100mg a day each week should be relatively painless.