« Abilify’s Side Effects, Warnings, etc. | Abilify’s Pharmacology »

US brand name: Abilify
Generic name: aripiprazole

Abilify’s Pros and Cons


  • As it sort of acts as a Parkinson’s/RLS med, so you’re somewhat less likely to get a couple of the more annoying AP side effects - most movement disorders and those involving prolactin.
  • The anticholinergic side effects are also less likely than other APs.
  • The long half-lives of of Abilify and its active metabolite mean you don’t have to worry about a dosing schedule, and you can even take a tablet every other day.


  • Since it kind of acts like a Parkinson’s/RLS med, you can get the oddball side effects of a Parkinson’s/RLS med, like pathological gambling.
  • That also means you can’t take another dopamine agonist to deal with AP-induced movement disorders. So if you do get EPS and want to keep taking Abilify, you’ll need to take a potent anticholinergic like Cogentin, and probably wind up getting anticholinergic side effects after all.
  • Abilify’s long-ass half-lives mean if you two don’t get along you can be stuck with the side effects for at least one, and possibly two weeks after you stop taking it.

Interesting Stuff your Doctor Probably didn’t Tell You about Abilify

Abilify is the first third-generation antipsychotic (TGA) to hit the US market. TGAs are defined as being partial agonists at dopamine D2 receptors, and that’s what makes them act sort of like Parkinson’s/RLS meds. So, unlike Zyprexa, Abilify doesn’t just mask movement disorders by being a potent anticholinergic, it tries to prevent them from happening in the first place.

Best Known for

The Hiccups of Death. AKA the Abilify Burp.

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« Abilify’s Side Effects, Warnings, etc. | Abilify’s Pharmacology »

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Last modified on Wed, 04 May, 2016 at 16:32:50 by JerodPoorePage Author Date created Tuesday, 29 November 2011 at 11:57:45
“Abilify (aripiprazole): Pros and Cons” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/11/29

Abilify, and all other drug names on this page and used throughout the site, are the trademarks of someone else. Abilify’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

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