Follow these links to the previous and next pages, or the index page.
Drug Guide Index
Clicking on a link in the Table of Contents will take you to that section of the drug guide.

The Expanded Approved and Off-label Uses Page provides details about:

  • FDA-approved uses of a drug
  • What a drug might be approved for outside of the US that it is currently not approved for here. E.g. Cymbalta is approved to treat stress urinary incontinence in the EU.
  • Common/Clinically significant off-label uses
  • Less common/experiment/freaking weird off-label uses
  • Failed off-label uses
  • Potentially dangerous off-label uses
  • When you should and should not be taking a med

We’ll often reference studies on this page. The BMJ has put together a collection of papers on how to read studies, trials, reviews, etc. It’s worth reading if you want to get serious about understanding how we go about researching all this.

1.  The drug’s US FDA approved use(s)

The list of FDA approvals. The newer PI sheets get into a lot of detail, and that detail is copied here. Otherwise we have to look up the stuff we want. Either way, this is what we try to get:

  • Date of approval for each application, like on the Zoloft page.
    • At the very least the date of a med’s initial approval in the US.
  • All of the super-specific applications for a med. E.g. Seroquel’s.
    • Which is nothing compared with how Lamictal was a few years back, or how some AEDs still are.
  • How different forms have different approvals. A better example than Seroquel is Paxil.

2.  Where a drug is approved elsewhere for:

Any approvals we can find in other countries that aren’t here. Such as Cymbalta’s (used as the global example), or how Lexapro/Cipralex is approved to treat panic disorders and social anxiety everywhere else it’s available, and OCD in many other countries.

3.  Common off-label uses

These are generally the clinically significant ones. Or the ones people take them for anyway, like Topamax for bipolar disorder. In either event we usually back these up with links to studies or clinical trials - the bigger the better - as seen on the Zoloft page.

I’m compelled to expose you to more of teh Google’s subliminal mind control devices Please enjoy this pleasant information-enhancement interlude.



4.  When / why you should take this drug

The circumstances that make taking a particular med a good idea. E.g. Switching from Risperdal to Invega.

5.  When / why you should not take this drug

The circumstances that make taking a particular med a bad idea. E.g. Switching from Risperdal to Invega.

Again with the ads? Really?



6.  Less common/experimental off-label uses of this med

When all else fails and you’ve run out of other options a drug you never expected may be your last best chance at treating an obscure or treatment-resistant condition.
Plus we run across some weird stuff all the time and feel like sharing.

7.  Failed off-label uses

This is mainly for examples of often used off-label applications that have a much higher failure rate than most people think.

8.  Potentially dangerous off-label uses

Sometimes they really aren’t worth trying. Otherwise safe meds can be downright dangerous when used for some things.



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Drug Guide Index
Follow these links to the previous and next pages, or the index page.




Page created by: Jerod Poore. Date created: 2 August 2011 Last edited by:





Page design and explanatory material by Jerod Poore, copyright © 2004 - 2014. All rights reserved.
Keep up with Crazymeds and and/or my slow descent into irreparable madness boring life. Pick your preferred social media target(s):

Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
Crazymeds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore


1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas? I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

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