approved indications and clinically-significant off-label uses, as well as experimental and failed applications

> Wellbutrin Approved and Off Label Uses


Brand and Generic Availability | Wellbutrin Index | How Long & How Likely To Work, Comparisons with Other Meds
Return to the Wellbutrin Page

Psychopharmacological Need for Approval

Drugs are officially approved to be used for certain things, and they may be approved for one thing in one country but something else entirely in another.1

Meds are often prescribed for conditions (e.g. Topamax for bipolar disorder), or people (e.g. adolescents being prescribed any SSRI or SNRI except Prozac or Lexapro) they aren’t approved to treat. This is known as off-label prescribing. Some off-label prescribing is so common that lots of people think the medication is a first-line treatment for the condition it’s prescribed to treat (e.g. Trileptal for bipolar disorder). If a drug company’s sales force (a.k.a. pharm reps) is too aggressive in pushing a med for off-label applications where it doesn’t work as well as people think, the FDA will now come down hard on them (e.g. Novartis getting heavily fined for promoting Trileptal as a treatment for bipolar disorder).

Stick to your treatment plan with buttons and magnets.
Pile of Pills buttons at Straitjacket T-shirts
Pile of Pills
Vaccines Cause Immunity buttons at Straitjacket T-shirts
Vaccines Cause Immunity
2.25″ $4 & 3.5″ $4.50 at Straitjacket T-shirts
Medicated For Your Protection magnets at Straitjacket T-shirts
Medicated For
Your Protection
Fuck Bipolar buttons at Straitjacket T-shirts
Fuck Bipolar

Off-label prescribing is not necessarily bad. Drugs that almost, or would almost, pass a clinical trial for some indication still work for a lot of people. As long as the reason for not clearing the hurdles of phase III clinical trials wasn’t the death of too many participants, or some other intolerable side effect.

Wellbutrin is US FDA-Approved to Treat:

  • Major depressive disorder.
  • Wellbutrin XL is approved for seasonal affective disorder (SAD).
  • As Zyban sustained-release bupropion is approved for smoking cessation.

Wellbutrin (bupropion) is Approved Elsewhere for:

The US and Canada are the only countries I’ve found so far where bupropion is approved as an antidepressant. Everywhere else on the planet where you find bupropion it’s approved only for smoking cessation, usually under the Zyban trade name.

Clinically Significant or Otherwise Common Off-Label Uses of Wellbutrin (bupropion)

* Weight loss
See the page on Wellbutrin’s efficacy for details on the likelihood Wellbutrin (bupropion) will work for approved indications and off-label uses.

Just because a medication is approved or commonly prescribed for a particular condition doesn’t necessarily mean you should be taking it for that condition. There could be a drug that might be better to try first, or at least talk to your doctor about trying first, such as Topamax instead of Depakote as a daily med to prevent migraines (and Topamax has its own reasons why you should and should not take it). Or the condition you have isn’t bad enough to warrant medication at all. E.g. any antidepressant if you’re not so depressed that you can function at relatively the same level as you do when you’re not depressed.

Get mugged at Straitjacket T-shirts for Crazymeds mugs
I <3 Wellbutrin mugs at Straitjacket T-shirts
I <3 Wellbutrin
Depression Sucks! mugs at Straitjacket T-shirts
Depression Sucks!
to wash down your Wellbutrin before you start crying. 11oz $13 & 15oz $14
Mentally Interesting mugs at Straitjacket T-shirts
Mentally Interesting
Medicated for your Protection mugs at Straitjacket T-shirts
Medicated for your Protection

When/Why You Should Take Wellbutrin (bupropion)

  • The primary symptoms of your depression include:
    • anhedonia (Nothing, absofuckinglutely nothing gives you any pleasure of any kind any more. See the South Park episode “I Have Cynicism” for an example.)
    • you can’t make decisions
    • you can’t even conceive of how to start anything, such as getting out of bed
  • You’ve been self-medicating with tobacco.

When/Why You Should NOT Take Wellbutrin (bupropion)

When all else fails and you’ve run out of other options, Wellbutrin may be your last best chance at treating an obscure or treatment-resistant condition.

Less Common/Experimental Off-Label Uses of Wellbutrin

* Crohn’s disease


Get Your Brain Cooties Shot at Straitjacket T-Shirts. Clothing, Mugs, Buttons, Magnets and Stickers
Bipolar is NOT Contagious shirts at Straitjacket T-shirts
Bipolar is NOT Contagious
PTSD is NOT Contagious mugs at Straitjacket T-shirts
PTSD is NOT Contagious
Epilepsy is NOT Contagious buttons at Straitjacket T-shirts
Epilepsy is NOT Contagious
Mental Illness is NOT Contagious stickers at Straitjacket T-shirts
Mental Illness is NOT Contagious

You don’t have to buy anything. Look around. Share what you like with your Pinterwit friends. Maybe they’ll buy it for you. Probably not.




Be careful! Some off-label uses have been total fails, and otherwise safe meds can be downright dangerous when used for some things.
You probably want to avoid using Wellbutrin for the following:

Failed Off-Label Uses

  • Pathological gambling
  • Parkinson’s - but it works for some of the side effects the meds cause (obviously not pathological gambling), and associated symptoms like depression.

Potentially Dangerous Off-Label Uses

  • Weight loss, because Wellbutrin + anorexia nervosa = seizures


Keep Crazymeds on the air.
Donate some spare electronic currency
you have floating around The Cloud
Display your mad pride.    
Tell your imaginary friends about Crazymeds.

References

Wellbutrin (bupropion) Full US Prescribing Information

Novartis Pharmaceuticals Corporation to Pay $422.5 Million for Off-Label Drug Marketing Food and Drug Administration Office of Criminal Investigations September 30, 2010 Last accessed 02 July 2014.

Brand and Generic Availability | Wellbutrin Index | How Long & How Likely To Work, Comparisons with Other Meds


1 Before Cymbalta (duloxetine) was approved as an antidepressant in the US it was already approved in the EU, but only for stress urinary incontinence and sold under the trade name Yentreve. Duloxetine is now sold in the EU as an antidepressant under the trade name Cymbalta.
A better known, if slightly different example is bupropion. According to the 2007 edition of Mosby's Drug Consult, and my highly-skilled Google-fu, in the US, Canada and Singapore you can get both Wellbutrin (bupropion) as an antidepressant or as Zyban (bupropion) to stop smoking. In Korea, Thailand and most of South America (but not Brazil) you can get bupropion (under various trade names) only as an antidepressant. In Brazil, the EU & UK, Israel, India, Australia and New Zealand it's only available as Zyban to help you stop smoking.


If you have any questions not answered here, please see the Crazymeds Wellbutrin discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)


Last modified on Sunday, 20 July, 2014 at 15:01:41 by JerodPoorePage Author Date created
“Wellbutrin (bupropion): a Synopsis for the Educated Consumer.” by Jerod Poore is copyright © Jerod Poore Published online 2011/03/27
Citation options to copy & paste into your article:
Plain text:Poore, Jerod. “Wellbutrin (bupropion): a Synopsis for the Educated Consumer.” Crazymeds (crazymeds.us). ().
with Microdata: <span itemprop='citation'>Poore, Jerod. "Wellbutrin (bupropion)." <em>Crazymeds (crazymeds.us)</em>.().</span>
Linked:<a href="http://scholar.google.com/citations?user=5rkux7sAAAAJ&hl=en&oi=sra">Poore, Jerod</a>. <a href='http://www.crazymeds.us/pmwiki/pmwiki.php/Meds/WellbutrinApprovedAndOffLabelUses'>"Wellbutrin (bupropion): a Synopsis for the Educated Consumer."</a>. <a href="http://www.crazymeds.us/pmwiki/pmwiki.php/Main/HomePage"> <em>Crazymeds (crazymeds.us)</em></a>. ().
with Microdata:<span itemprop='citation'> <a href="http://scholar.google.com/citations?user=5rkux7sAAAAJ&hl=en&oi=sra">Poore, Jerod</a>. <a href='http://www.crazymeds.us/pmwiki/pmwiki.php/Meds/WellbutrinApprovedAndOffLabelUses'>"Wellbutrin (bupropion): a Synopsis for the Educated Consumer."</a>. <a href="http://www.crazymeds.us/pmwiki/pmwiki.php/Main/HomePage"> <em>Crazymeds (crazymeds.us)</em></a>. ().</span>

Wellbutrin, and all other drug names on this page and used throughout the site, are a trademark of someone else.

will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.




Page design and explanatory material by Jerod Poore, copyright © 2004 - 2014. All rights reserved.
Keep up with Crazymeds and and/or my slow descent into irreparable madness boring life. Pick your preferred social media target(s):

Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
Crazymeds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore


1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas? I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

Enable Crazymeds’ Financial Solvency!

Enable Crazymeds to keep spreading our knowledge. Donate some spare e-currency you have floating around The Cloud.

Improve Your Social Media Skills

Net.Presents

Follow our Highly Irregular Updates and Paranoid Rants Other News on All* Social Media

Crazymeds

Show us teh like™

Square this Circle


Sites That Probably Suck Less Than Crazymeds

Crazymeds Merchandise

You don’t have to buy anything.
Sharing what you’d like to buy
helps support this site.

Available at Straitjacket T-Shirts

Medicated for your Protection Hoodie at Straitjacket T-Shirts

Clothes Hoist
T-Shirts, Hoodies & More $14-$55


Pile of Pills Mug at Straitjacket T-Shirts

Get Mugged
11oz $13 & 15oz $14


Vaccines Cause Immunity Bumpersticker at Straitjacket T-Shirts

Stuck Up
All stickers $5. Now Available in Packs of 10 & 50


Mentally Interesting Button at Straitjacket T-Shirts

Button It!
2.25″ $4 & 3.5″ $4.50. Now Available in Packs of 10 & 100


Charming Pills Necklace at Straitjacket T-Shirts

Dangly Bits
Bracelets, Necklaces and Other ‘Jewelry’ $15 - $40


Brain Cooties Aren't Contagious Magnet at Straitjacket T-Shirts

Magnetic Personality Disorders
2.25″ $4, Larger Sizes $4.50. Some Designs in Packs of 10 & 100


Pile of Pills Journal at Straitjacket T-Shirts

Not Otherwise Specified
Journals, Mousepads, Home Decor, Clocks, Assorted Crap $5 - $85


Pile of Pills Phone Cases at Straitjacket T-Shirts

Hold the Phone
Cases & Sleeves for Phones & Similar Devices $18 - $47


You don’t have to buy anything. Windows shop. Tweet what you like to your Pinbook circle. It might be less boring than whatever you’re doing now.

Burning Mind Books

Psychopharmacology tomes at Burning Mind Books

Books & Other Media for the Mentally Interesting

Replace my awful design choices with your own

Return to the Original Flavor

* Where I bother to get an account for the Crazymeds site.
I, on the other hand, am everywhere.
Just trying to make things easier for the sad, overweight, greasy sociopaths of the world.

dimension