side effects, dosage, how to take & discontinue, uses, pros & cons, and more
> Viibryd (vilazodone) Overview
Viibryd Article Index | Brand and Generic Availability ›
Brand & Generic Names; Drug Class
US FDA Approved Treatment(s)
Major Depressive Disorder (MDD). Approved 21 January 2011.
Learn More about Viibryd’s Approved & Off-label Uses
How Long Until Viibryd Starts Working (Onset of Action)
At least a month, which surprises me.
Likelihood of Working
Based on what I can find so far: pretty good. At least if your doctor can tell that an SSRI would be the way to go and you have a strong stomach.
Learn how Viibryd Compares with Other Drugs
How to Take Viibryd
Forest Pharmaceuticals and Merck recommend:
--the Viibryd PI sheet
The recommended dose for VIIBRYD is 40 mg once daily.
VIIBRYD should be titrated, starting with an initial dose of 10 mg once daily for 7 days, followed by 20 mg once daily for an additional 7 days, and then an increase to 40 mg once daily . VIIBRYD should be taken with food.
At this point we don’t have much to suggest, other than taking it with breakfast instead of dinner when you first try it. Based upon Viibryd’s mechanism of action (how Viibryd works), side effects, and consumer experiences, taking Viibryd in the morning seems to work better for more people.
Since Viibryd tends to take a long time to work it’s hard to tell if staying at 20mg (or even 10mg) for longer than a week would be helpful or not. Obviously if it works at 10 or 20mg, then just stay at that dosage. If the side effects become too harsh at 40mg, and you feel like 20mg of Viibryd was starting to do something, then talk to your doctor ASAP about going back down to 20mg and giving it a chance to work at that dosage.
How to Stop Taking Viibryd (Discontinue, Withdrawal)
Forest, being Forest, are vague and state the obvious. The only thing helpful they offer is a highly detailed description of SSRI-discontinuation syndrome symptoms:
5.6 Discontinuation of Treatment with VIIBRYD
There have been reports of adverse events occurring upon discontinuation of serotonergic antidepressants, particularly when discontinuation is abrupt, including the following:
dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia, such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures.
While these events are generally self-limiting, there have been reports of serious discontinuation symptoms. Monitor patients for these symptoms when discontinuing
VIIBRYD. Reduce the dose gradually whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, consider
resuming the previously prescribed dose. Subsequently, the dose may be decreased, but at a more gradual rate
Learn More about Taking and Discontinuing Viibryd
As with any potent SSRI: very slowly and carefully. Withdrawing Viibryd the same way you titrated (increased the dosage) should work for most people: from 40mg to 20mg for 7 days, then 10mg for 7 days, then you’re done. You might be able to get a starter kit from your doctor. Some people may need to do 40mg to 30mg to 20mg to 10mg.
Viibryd’s Pros and Cons
I honestly can’t find what makes it a better choice than other antidepressants.
Takes a long time to work.
Interesting Stuff your Doctor Probably didn’t Tell You about Viibryd
From the PI sheet: ‘’Absorption is decreased by approximately 25% if vomiting
occurs within 7 hours of ingestion.’‘
The only reason that’s interesting is it’s the first time I’ve found the answer to the question, “What happens if I puke after taking my meds?” Viibryd is turning out to be pretty boring.
Vybrid - note the spelling difference - is the name of a microprocessor used in industrial machinery (assembly-line robots e.g.) and a line of shoes with the “five-finger” design. Like gloves for your feet. As a common misspelling for Viibryd I’m sure both companies are pleased to no end that crazies conflate their products with a crazy med.
Best Known for
Giving you diarrhea that’s worse than what you’d get from drinking a quart of Tijuana tap water.1
In-Depth Pros & Cons
Don’t worry about buying one. Windows shop and share the designs you’d like to buy. Do you have anything better to do right now?
Viibryd’s Potential Side Effects (Adverse Reactions)
Typical Side Effects
Diarrhea, nausea & vomiting, the shits, excessive sleep or insomnia, and the runs.
I’m still trying to get a handle as to how common or uncommon, permanent or transient, sexual dysfunction and weight gain really are.
Uncommon Side Effects
Dizziness, tremor, anxiety, and headaches that reach migraine intensity.
Freaky Rare Side Effects
Pollakiuria. In English: an overactive bladder. Viibryd is just way too new to have any decent freaky rare side effects. Give it time.
Learn More about Viibryd’s Side Effects.
TMI at times
What You Really Need to be Careful About
Viibryd’s Black Box and Other Warnings, Pregnancy Category, etc.
Half-life is the average time it takes for you to process half of the drug’s active ingredient. If a drug has a half-life of around 24 hours and you take a dose of 100mg, you’ll have roughly the equivalent a 50mg dose after one day, a 25mg dose after two days, and so on. The rule of thumb is: multiply the half-life by five and you get how long it is for the dose you took to be cleared from your bloodstream, so there’s nothing swimming around to attach itself to your brain and start doing stuff2. That’s called “plasma clearance.” Complete clearance is a complex equation based on a lot of factors which may or may not: be published in the PI sheet, include personal data like your weight, or even completely figured out by corporate and independent researchers. It usually winds up being 2–5 days after plasma clearance no matter what3, but can take weeks. Sometimes a drug will clear from your brain and other organs before it clears from your blood. If we’ve found the complete clearance, or how to calculate it if it requires things like your weight and what your piss looks like, you’ll find that on vilazodone’s pharmacokinetics page.
You don’t have to buy anything. Look around the store. Tweet what you like to your Pinbook Circle. Do you have anything better to do right now?
As if I didn’t go on long enough already.
Ratings, Reviews, Comments, PI Sheet, and More
I’m disappointed with Viibryd. Not from taking it, as anything like an SSRI and I don’t get along. I disappointed because this is the most boring drug on the planet. When I started studying its mechanism of action I thought it would be something really useful, even if it is essentially Paxil and BuSpar in one pill. Once I started reading people’s experiences it turns out that a Paxil and BuSpar cocktail isn’t universally effective for people who sort of respond to SSRIs. If an SSRI worked for you and pooped out, Viibryd is worth a shot. Although “pooped out” will probably take on an entirely new meaning, as you’ll probably poop out everything you eat within 10 minutes for the first few weeks. Or for as long as you take it. If SSRIs or SNRIs never worked for you, Viibryd would be a waste of time and side effects.
Give your overall impression of Viibryd on a scale of 0 to 5. Detailed ratings and reviews are available on the Viibryd Ratings & Reviews Page.
Get all critical about Viibryd
Rating 2.7 out of 5 from 125 criticisms.
Vote Distribution: 33 – 7 – 8 – 12 – 44 – 21
Rate this article
If you’re still feeling judgmental as well as just mental4, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.
Get all judgmental about the Viibryd (vilazodone) Overview
Rates 3.4 out of 5 from value judgments.
Vote Distribution: 5 – 3 – 3 – 12 – 23 – 12
It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.
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- Viibryd’s Full US Prescribing Information
- Faught, Edward. “Topiramate in the treatment of partial and generalized epilepsy.” Neuropsychiatric disease and treatment 3.6 (2007): 811-821.
Viibryd Article Index | Brand and Generic Availability ›
1 In all fairness to Mexico I found the tap water in San Jose del Cabo to taste vastly better than the tap water in Peoria, IL. Then again, the water in San Jose del Cabo tastes better than the unfiltered tap water from my house, while the water in Peoria tastes almost as bad as the oral solution of some meds.
2 Based on Julien's calculations from A Primer of Drug Action, the half-life multiplied by five is the generally accepted estimate of how long it takes a single dose of any given drug to be eliminated from the blood stream/plasma of someone with a normal metabolism. That's also the rough estimate for steady stage if they can't get, or won't provide a number for that.
3 For crazy meds. I have no idea what the average complete clearance is for other types of medications. For all I know there are drugs that utterly vanish from your system in under five passes, and others that won't let go of your squishy bits for years after you stop taking them.
4 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!
5 These include: Canada's Product Monographs (PM), New Zealand's Medicine Data Sheets (MDS), the EU's European Public Assessment Reports (EPAR), and the Summary of Product Characteristics (SPC) used in Britain, Ireland, and many other places.
If you have any questions not answered here, please see the Crazymeds Viibryd discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)
|Last modified on Monday, 06 October, 2014 at 16:27:37 by JerodPoore||Page Author Jerod Poore||Date created Saturday, 14 July 2012 at 13:07:53|
|“Viibryd (vilazodone): a Synopsis for the Educated Consumer.” by Jerod Poore is copyright © 2012 Jerod Poore ||Published online 2012/07/14|
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Viibryd, and all other drug names on this page and used throughout the site, are a trademark of someone else. Viibryd’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.
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All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
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Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList,
NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
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‘Everything is true, nothing is permitted.’ - Jerod Poore
1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.
* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.
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