side effects, dosage, reviews, how to take & discontinue, uses, pros & cons, and more

> Viibryd (vilazodone) Overview


Viibryd Article Index | Brand and Generic Availability

Brand & Generic Names; Drug Class

US brand name: Viibryd
Generic name: vilazodone
Drug Class: Antidepressants
Learn More about Viibryd’s Generic & Worldwide Availability

Viibryd’s Approved & Off-Label Uses (Indications)

US FDA Approved Treatment(s)

Major Depressive Disorder (MDD). Approved 21 January 2011.

Popular Off-Label Uses

Anxiety

Learn More about Viibryd’s Approved & Off-label Uses

How Long Until Viibryd Starts Working (Onset of Action)

At least a month, which surprises me.

Likelihood of Working

Based on what I can find so far: pretty good. At least if your doctor can tell that an SSRI would be the way to go and you have a strong stomach. Learn how Viibryd Compares with Other Drugs

How to Take Viibryd

Manufacturers’ Recommendations

Forest Pharmaceuticals and Merck recommend:

The recommended dose for VIIBRYD is 40 mg once daily.
VIIBRYD should be titrated, starting with an initial dose of 10 mg once daily for 7 days, followed by 20 mg once daily for an additional 7 days, and then an increase to 40 mg once daily . VIIBRYD should be taken with food.

--the Viibryd PI sheet

Crazymeds’ Suggestions

At this point we don’t have much to suggest, other than taking it with breakfast instead of dinner when you first try it. Based upon Viibryd’s mechanism of action (how Viibryd works), side effects, and consumer experiences, taking Viibryd in the morning seems to work better for more people.

Since Viibryd tends to take a long time to work it’s hard to tell if staying at 20mg (or even 10mg) for longer than a week would be helpful or not. Obviously if it works at 10 or 20mg, then just stay at that dosage. If the side effects become too harsh at 40mg, and you feel like 20mg of Viibryd was starting to do something, then talk to your doctor ASAP about going back down to 20mg and giving it a chance to work at that dosage.


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How to Stop Taking Viibryd (Discontinue, Withdrawal)

Manufacturers’ Recommendations

Forest, being Forest, are vague and state the obvious. The only thing helpful they offer is a highly detailed description of SSRI-discontinuation syndrome symptoms:

5.6 Discontinuation of Treatment with VIIBRYD
There have been reports of adverse events occurring upon discontinuation of serotonergic antidepressants, particularly when discontinuation is abrupt, including the following:
dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia, such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures.
While these events are generally self-limiting, there have been reports of serious discontinuation symptoms. Monitor patients for these symptoms when discontinuing VIIBRYD. Reduce the dose gradually whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, consider resuming the previously prescribed dose. Subsequently, the dose may be decreased, but at a more gradual rate

Crazymeds’ Suggestions

As with any potent SSRI: very slowly and carefully. Withdrawing Viibryd the same way you titrated (increased the dosage) should work for most people: from 40mg to 20mg for 7 days, then 10mg for 7 days, then you’re done. You might be able to get a starter kit from your doctor. Some people may need to do 40mg to 30mg to 20mg to 10mg. Learn More about Taking and Discontinuing Viibryd



Viibryd’s Pros and Cons

Pros

I honestly can’t find what makes it a better choice than other antidepressants.

Cons

Takes a long time to work.

Interesting Stuff your Doctor Probably didn’t Tell You about Viibryd

From the PI sheet: ‘’Absorption is decreased by approximately 25% if vomiting occurs within 7 hours of ingestion.’‘
The only reason that’s interesting is it’s the first time I’ve found the answer to the question, “What happens if I puke after taking my meds?” Viibryd is turning out to be pretty boring.

Vybrid - note the spelling difference - is the name of a microprocessor used in industrial machinery (assembly-line robots e.g.) and a line of shoes with the “five-finger” design. Like gloves for your feet. As a common misspelling for Viibryd I’m sure both companies are pleased to no end that crazies conflate their products with a crazy med.

Best Known for

Giving you diarrhea that’s worse than what you’d get from drinking a quart of Tijuana tap water.1


In-Depth Pros & Cons

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Viibryd’s Side Effects (Adverse Reactions)

Typical Side Effects

Diarrhea, nausea & vomiting, the shits, excessive sleep or insomnia, and the runs.
I’m still trying to get a handle as to how common or uncommon, permanent or transient, sexual dysfunction and weight gain really are.

Uncommon Side Effects

Dizziness, tremor, anxiety, and headaches that reach migraine intensity.

Freaky Rare Side Effects

Pollakiuria. In English: an overactive bladder. Viibryd is just way too new to have any decent freaky rare side effects. Give it time.
Learn More about Viibryd’s Side Effects.
TMI at times


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What You Really Need to be Careful About

Viibryd’s Black Box and Other Warnings, Pregnancy Category, etc.

Pharmacology

vilazodone’s Half-Life & How Long Until It Clears Your System

Plasma half-life: Half-life: 25 hours. Clearance: five-six days.

vilazodone’s Pharmacokinetics Information Overload

Half-life is the average time it takes for you to process half of the drug’s active ingredient. If a drug has a half-life of around 24 hours and you take a dose of 100mg, you’ll have roughly the equivalent a 50mg dose after one day, a 25mg dose after two days, and so on. The rule of thumb is: multiply the half-life by five and you get how long it is for the dose you took to be cleared from your bloodstream, so there’s nothing swimming around to attach itself to your brain and start doing stuff2. That’s called “plasma clearance.” Complete clearance is a complex equation based on a lot of factors which may or may not: be published in the PI sheet, include personal data like your weight, or even completely figured out by corporate and independent researchers. It usually winds up being 2–5 days after plasma clearance no matter what3, but can take weeks. Sometimes a drug will clear from your brain and other organs before it clears from your blood. If we’ve found the complete clearance, or how to calculate it if it requires things like your weight and what your piss looks like, you’ll find that on vilazodone’s pharmacokinetics page.

How vilazodone Works

the current best guess at any rate
Viibryd is a potent serotonin-selective reuptake inhibitor (SSRI) with the added bonus of being a partial 5-HT1A agonist. In English: It’s like taking Paxil and BuSpar.

Learn More than You Probably Ever Wanted to Know about How vilazodone Works
AKA mechanism/method of action, pharmacodynamics


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Ratings, Reviews, Comments, PI Sheet, and More

Viibryd Comments

I’m disappointed with Viibryd. Not from taking it, as anything like an SSRI and I don’t get along. I disappointed because this is the most boring drug on the planet. When I started studying its mechanism of action I thought it would be something really useful, even if it is essentially Paxil and BuSpar in one pill. Once I started reading people’s experiences it turns out that a Paxil and BuSpar cocktail isn’t universally effective for people who sort of respond to SSRIs. If an SSRI worked for you and pooped out, Viibryd is worth a shot. Although “pooped out” will probably take on an entirely new meaning, as you’ll probably poop out everything you eat within 10 minutes for the first few weeks. Or for as long as you take it. If SSRIs or SNRIs never worked for you, Viibryd would be a waste of time and side effects.
Extended Comments
As if I didn’t go on long enough already.

Viibryd Ratings & Reviews, and Consumer Comments & Experiences

Rate Viibryd

Give your overall impression of Viibryd on a scale of 0 to 5. Detailed ratings and reviews are available on the Viibryd Ratings & Reviews Page.

Get all critical about Viibryd

3 stars Rating 2.8 out of 5 from 108 criticisms.
Vote Distribution: 27 – 6 – 7 – 10 – 39 – 19


Rate this article

If you’re still feeling judgmental as well as just mental4, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.

Get all judgmental about the Viibryd (vilazodone) Overview

3.5 stars Rates 3.5 out of 5 from 48 value judgments.
Vote Distribution: 3 – 3 – 2 – 11 – 19 – 10


Discussion board

Consumer experiences with and questions about Viibryd on Crazymeds Viibryd discussion board. Sign up for a free account to post your own.

More Allegedly Useful Links. Mostly official sites, PI sheet-equivalents5 from countries other than the US, and reviews from other consumer review sites.


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It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.



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References

  1. Viibryd’s Full US Prescribing Information
  2. Faught, Edward. “Topiramate in the treatment of partial and generalized epilepsy.” Neuropsychiatric disease and treatment 3.6 (2007): 811-821.

Viibryd Article Index | Brand and Generic Availability

1 In all fairness to Mexico I found the tap water in San Jose del Cabo to taste vastly better than the tap water in Peoria, IL. Then again, the water in San Jose del Cabo tastes better than the unfiltered tap water from my house, while the water in Peoria tastes almost as bad as the oral solution of some meds.

2 Based on Julien's calculations from A Primer of Drug Action, the half-life multiplied by five is the generally accepted estimate of how long it takes a single dose of any given drug to be eliminated from the blood stream/plasma of someone with a normal metabolism. That's also the rough estimate for steady stage if they can't get, or won't provide a number for that.

3 For crazy meds. I have no idea what the average complete clearance is for other types of medications. For all I know there are drugs that utterly vanish from your system in under five passes, and others that won't let go of your squishy bits for years after you stop taking them.

4 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!

5 These include: Canada's Product Monographs (PM), New Zealand's Medicine Data Sheets (MDS), the EU's European Public Assessment Reports (EPAR), and the Summary of Product Characteristics (SPC) used in Britain, Ireland, and many other places.


If you have any questions not answered here, please see the Crazymeds Viibryd discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)


Last modified on Monday, 06 October, 2014 at 16:27:37 by JerodPoorePage Author Date created Saturday, 14 July 2012 at 13:07:53
“Viibryd (vilazodone): a Synopsis for the Educated Consumer.” by Jerod Poore is copyright © 2012 Jerod Poore Published online 2012/07/14
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Viibryd, and all other drug names on this page and used throughout the site, are a trademark of someone else.

will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.




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Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
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Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

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3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas? I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

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