generic name: nefazodone

Class: Antidepressants Nefazodone is a serotonin antagonist and reuptake inhibitor - (SARI) - like its chemical cousin trazodone.

1.  FDA Approved Uses of nefazodone

Depression

2.  Off-Label Uses of nefazodone

Good luck getting any doctor to prescribe nefazodone for depression, let alone an off-label application.

3.  Nefazodone’s pros and cons

3.1  Pros

Highly effective, especially in preventing relapses. Low instances of sexual side effects.

3.2  Cons

Doctors are afraid to prescribe it, which is probably just as well because it will probably get pulled from the market completely any day now. Lots and lots of drug-drug interactions.

4.  Side Effects

4.1  Typical Side Effects

The usual anticholinergic-like side effects one gets with meds that have a positive effect on both serotonin and norepinephrine: headache, nausea, dry mouth, sweating, dizziness, blurred vision, sleepiness or insomnia, and constipation. Because nefazodone isn’t much of an anticholinergic none of these sticks around very much. Except for the sleepiness.

4.2  Not So Common Side Effects

Urinary retention or hesitancy, which is something that either sticks around or strikes at random. A variety of vision weirdness - go ahead and get your eyes checked, but if an eye doctor doesn’t find anything on a cursory examination, it’s not your eyes, it’s the Serzone. Priapism. Liver problems severe enough that you have to immediately stop taking it, which is why nefazodone has been yanked from the market most everywhere.

4.3  Freaky Rare Side Effects

The inability to produce clear speech. 3-day long clitoral priapism

5.  Interesting Stuff Your Doctor Probably Won’t Tell You

Don’t take nefazodone with food, as you’ll be getting less out of it. The bioavailability of Serzone is bad enough to start (20% or less), taking it with food just makes it worse.

Apparently nefazodone has a discontinuation syndrome that is almost Effexor-like in severity. Which is just fabulous for anyone who lives somewhere it becomes suddenly unavailable.

1

6.  Serzone’s (nefazodone) Dosage and How to Take nefazodode

7.  How Long nefazodone Takes to Work

8.  How to Stop Taking nefazodone

Nefazodone discontinuation syndrome full text switching to an SSRI may not help

9.  Nefazodone’s Half-Life & Average Time to Clear Out of Your System

10.  Days to Reach a Steady State

Usually two to three days.

11.  How Nefazodone Works

12.  Comments

13.  Discussion board

Crazy Meds’ Serzone discussion board

14.  Your Comments About and Experiences with Serzone

26 March 2011 - 18:45  

Jerod Poore   wrote:

Your experiences with Serzone

Tell us what you think about Serzone

Enter your own Comments & Experiences with Serzone here.
You must be a registered member of the Crazy Meds Talk forum to post a comment on this page.

15.  Full US PI sheet, Global SPCs & PILs, check for drug-drug interactions

Serzone Full US Prescribing Information / PI Sheet

Check for drug-drug interactions

16.  Bibliography

Physicians’ Desk Reference Edition 53 © 1999. Published by Medical Economics Company.

Consumer’s Guide to Psychiatric Drugs by John D. Preston Psy.D., John H. O’Neal, M.D. & Mary C. Talaga R.Ph., M.A. © 2000. Published by New Harbinger Publications.

Psychopharmacology of Antidepressants Stephen M. Stahl, M.D., Ph. D. © 1997. Published by Martin Dunitz

1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.



Date created 26 Mar 2011 - 18:45 Page Creator: JerodPoore Last edited by:


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