Table of Contents (hide)
- 1. Brand & Generic Names; Drug Class
- 2. What is Seroquel-XR (quetiapine fumarate) Used For?
- 3. When Will Seroquel-XR (quetiapine fumarate) Start Working?
- 4. Will Seroquel-XR Really Work for What You Have?
- 5. How to Take Seroquel-XR (quetiapine fumarate)
- 6. How to Stop Taking Seroquel-XR (quetiapine fumarate)
- 7. Seroquel-XR (quetiapine fumarate) Pros and Cons
- 8. Seroquel-XR (quetiapine fumarate) Side Effects
- 9. What You Really Need to be Careful About with Seroquel-XR (quetiapine fumarate)
- 10. Seroquel-XR (quetiapine fumarate) Half-Life & How Long Until Seroquel-XR Clears Your System
- 11. How Seroquel-XR (quetiapine fumarate) Works
- 12. Comments, Seroquel-XR PI Sheet, and More
Seroquel-XR (quetiapine fumarate) highlights: side effects, dosage, reviews, how to take & discontinue, uses, etc. The “More…” links are to pages with greater detail. The Comprehensive Seroquel-XR pages have all information from all the “More about…” pages, but with less explanatory material.
§1. Brand & Generic Names; Drug Class
|US brand name:||Seroquel-XR|
|Generic name:||quetiapine fumarate|
|What is Seroquel-XR (quetiapine fumarate)?|
|Seroquel-XR (quetiapine fumarate) is in the Antipsychotics class of drugs.|
§2. What is Seroquel-XR (quetiapine fumarate) Used For?
§2.1 US FDA Approved Treatment(s)
Schizophrenia, bipolar disorder, as an add-on to an antidepressant to treat depression
§2.2 Popular Off-Label Uses
Insomnia, anxiety, Parkinson’s
§3. When Will Seroquel-XR (quetiapine fumarate) Start Working?
Unlike other antipsychotics, which can start getting your symptoms under control within 24 hours, Seroquel can take up to a week to work. Unless you’re taking it for sleep. That first 25mg knocks out most people.
§4. Will Seroquel-XR Really Work for What You Have?
Pretty good for schizophrenia, so-so for bipolar mania, fairly good for bipolar depression.
§5. How to Take Seroquel-XR (quetiapine fumarate)
For bipolar: PI sheet: start at 100mg a day in two 50mg doses and increase by 100mg to 400mg day by day four. If needed, up it by 200mg a day until reaching 800mg a day by day six.
We suggest starting with one 25–50mg dose at night if you’re taking another mood stabilizers, or the 100mg a day in two 50mg doses if you aren’t. If you need to increase by 25–50mg a day every 3–4 days and stay at whatever dosage gets your symptoms under control. Unless you’re seriously flipping out, in which case follow the PI sheet’s guidelines until your symptoms are under control or you hit 800mg a day. For schizophrenia: PI sheet: start at 50mg a day, divided into two 25mg doses, but they still want to ramp you up to 300–400mg a day by day four.
We suggest starting with 50mg a day and, as with bipolar disorder, increasing by 25–50mg every 3–4 days until your symptoms are under control. If you’re crazy enough to be getting coded messages in your cereal, then get to 300–400mg by day four.
§6. How to Stop Taking Seroquel-XR (quetiapine fumarate)
Your doctor should be recommending that you reduce your dosage by 25–50mg a day every other day if you need to discontinue it. You can stop taking all it immediately if it’s an emergency (e.g. a life-threatening allergic reaction), but I wouldn’t recommend doing that without a doctor’s supervision. The major problem with stopping antipsychotics is a sudden return of your symptoms.
§7. Seroquel-XR (quetiapine fumarate) Pros and Cons
As one of the mildest - and most prescribed - of all antipsychotics it doesn’t really carry the antipsychotic stigma as heavily as the other meds in this class. That also means it’s less likely to cause side effects involving prolactin (e.g. leaking nipples or man boobs) and movement disorders.
You’ll sleep until next Tuesday. Of course, that could be a good thing, depending on how your life is at this moment. Other than the sleep thing, it takes longer than any other atypical antipsychotic to work. You’ll probably gain weight and you might come down with type 2 diabetes.
§7.3 Interesting Stuff your Doctor Probably didn’t Tell You about Seroquel-XR (quetiapine fumarate)
Seroquel is marginally better absorbed with food. So if you feel you need just a little boost in the dosage, try taking it with dinner or a late night snack.
Like most drugs older people don’t clear it out of their systems as well, to the point that they may need a lower dosage. That’s not particularly interesting. What is interesting is that Seroquel seems to work better for people under 40 than over 40.
§7.4 What Seroquel-XR (quetiapine fumarate) Is Best Known for
Seroquel is notorious for two things - making you sleep until next Tuesday, and leaving you a hangover when you eventually wake up.
More pros, cons, and interesting stuff about Seroquel-XR
§8. Seroquel-XR (quetiapine fumarate) Side Effects
§8.1 Typical Seroquel-XR Side Effects
The usual short-term side effects for second-generation / atypical antipsychotics (SGA/AAP): headache, nausea, dry mouth, sleepiness or insomnia, diarrhea or constipation, not giving a damn about anything (a.k.a. the zombification effect). Most, if not all of these will go away in a couple of weeks. Except for the excessive sleepiness, which could hang around for as long as you take this med, but is usually not much of a problem once you’re taking more than 100–200mg a day.
However, the excessively sleepiness tends to return if you start taking over 400–600mg a day. That’s also interesting, but many doctors and/or pharmacists will tell you that.
And, of course, weight gain. Although it’s not as bad as Zyprexa.
§8.2 Uncommon Seroquel-XR Side Effects
Diabetes. Manic reaction. Muscle aches and pains. Getting all sweaty for no good reason. Tremor. Irregular heart beat and prolonged QT interval. While the sexual dysfunctions aren’t as bad as Risperdal (risperidone) or Zyprexa (olanzapine), they can still happen.
§8.3 Freaky Rare Seroquel-XR Side Effects
Infanticide. Priapism (the never-ending hard-on) from an overdose. Kids, don’t try this at home. The PI sheet also lists “bone pain” and “abnormal ejaculation” so I’d be especially careful about taking too much Seroquel as a Cialis substitute in order to stay hard.
More Seroquel-XR side effects
§9. What You Really Need to be Careful About with Seroquel-XR (quetiapine fumarate)
§10. Seroquel-XR (quetiapine fumarate) Half-Life & How Long Until Seroquel-XR Clears Your System
Half-life: 12 hours. Clearance: 3 days.
Drugs.com’s drug-drug and drug-food interaction checker
More Seroquel-XR pharmacokinetics & noted drug-drug & drug-food interactions
Clearance given here is “plasma clearance,” or how long it takes to be out of your blood so there’s nothing swimming around to attach itself to your brain and start doing stuff. Complete clearance is a complex equation based on a lot of factors which may or may not be published in the PI sheet or even figured out by independent researchers. If we’ve found it and calculated it you’ll find that on the pharmacokinetics page.
§11. How Seroquel-XR (quetiapine fumarate) Works
the current best guess at any rate
Seroquel is broad-spectrum antipsychotic, and is tied with Zyprexa for third place in how many, and which type, of neurotransmitter receptors it affects. Most of its activity involves reducing the activity 5HT-serotonin and alpha-1a & alpha-2c norepinephrine receptors. Seroquel also does a little norepinephrine reuptake inhibition and enhancement of the 5HT2 serotonin receptor, which accounts for its antidepressant effect.
More about how Seroquel-XR works. AKA Seroquel-XR mechanism/method of action, or pharmacodynamics.
§12. Comments, Seroquel-XR PI Sheet, and More
More comments As if I didn’t go on long enough here.
Seroquel-XR’s Full US Prescribing Information / PI Sheet
Consumer/patient comments about, reviews of, and experiences with Seroquel-XR
If you have any questions about Seroquel-XR (quetiapine fumarate), please see the Crazy Meds’ Seroquel-XR (quetiapine fumarate) discussion board
Allegedly Useful Links. Mostly official sites we could find for this med, PI sheets from countries other than the US, and reviews from consumer review sites.
Date created Tuesday, 25 January 2011 at 17:03:23 Page Author: Jerod Poore Last edited by: Jerod Poore on October 14, 2011, at 12:02 PM
Seroquel-XR is a trademark of someone else. Look on the the PI sheet or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?
[begin rant] I rent a dedicated server for Crazy Meds. It’s sitting on a rack somewhere in Southern California along with a bunch of other servers that other people have rented. The hardware is identical, but no two machines have exactly the same operating systems. I don’t even need to see what is on any of the others to know this. If somebody got their server at the exact same time, with the exact same features as I did, I’m confident that there would be noticeable differences in some aspects of the operating systems. So what does this mean? For one thing it means that no two computers in the same office of a single company have the same operating system, and the techs can spend hours figuring out what the fuck the problem could be based on that alone. It also means that application software like IP board that runs the forum here has to have so many fucking user-configurable bells and whistles that even when I read the manual I can’t find every setting, or every location that every flag needs to be set in order for a feature to run the way I want it to run. And in the real world it means you can get an MBA not only with an emphasis on resource planning, but with an emphasis on using SAP - a piece of software so complex there are now college programs on how to use it. You might think, “But don’t people learn how to use Photoshop or Adobe Illustrator in college?” Sure, in order to create stuff. And in a way you’re creating stuff with SAP. But do you get a Bachelor of Fine Arts degree with an emphasis on Photoshop?
Back in the Big Iron Age the operating systems were proprietary, and every computer that took up an entire room with a raised floor and HVAC system, and had less storage and processing power than an iPhone, had the same operating system as every other one, give or take a release level. But when a company bought application software like SAP, they also got the source code, which was usually documented and written in a way to make it easy to modify the hell out of it. Why? Because accounting principles may be the same the world over, and tax laws the same across each country and state, but no two companies have the same format for their reports, invoices, purchase orders and so forth. Standards existed and were universally ignored. If something went wrong it went wrong the same way for everyone, and was easy to track down. People didn’t need to take a college course to learn how to use a piece of software.
I’m not against the open source concept entirely. Back then all the programmers read the same magazines, so we all had the same homebrew utilities. We even had the forerunner to QR Code to scan the longer source code. Software vendors and computer manufacturers sponsored conventions so we could, among other things, swap recipes for such add-ons and utilities. While those things would make our lives easier, they had nothing to do with critical functions of the operating system. Unless badly implemented they would rarely cause key application software to crash and burn. Whereas today, with open source everything, who the hell knows what could be responsible some part of a system failing. [/end rant]
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