side effects, dosage, reviews, how to take & discontinue, uses, pros & cons, and more
Table of Contents (hide)
- 1. Brand & Generic Names; Drug Class
- 2. Approved & Off-Label Uses (Indications)
- 3. Usual Onset of Action (when it starts working)
- 4. Likelihood of Working
- 5. How to Take Risperdal
- 6. How to Stop Taking (discontinue / withdrawal) Risperdal
- 7. Pros and Cons
- 8. Side Effects
- 9. What You Really Need to be Careful About
- 10. Half-Life & How Long Until Risperdal Clears Your System
- 11. How Risperdal Works
- 12. Ratings, Reviews, Comments, PI Sheet, and More
|US brand name: Risperdal|
|Generic name: risperidone|
|Drug Class: Antipsychotics|
Schizophrenia in adults & adolescents; Bipolar 1 in adults, children & adolescents
Augmenting SSRIs to treat OCD and/or major depression. Panic/Anxiety.
Like most antipsychotics you’ll feel something the next day. Within five to six days you should have a decent idea if Risperdal is going to do anything for you. You and your doctor may not be sure if it’s positive or not, but by then you should at least know if Risperdal may work. Various studies and trials have shown results in 2 to 7 days.
The chances are pretty good that Risperdal (risperidone) will work for what can be ridiculously described as “basic,” “simple,” or even “normal” schizophrenia, schizoaffective and schizophreniform disorders. In equally simple terms, Risperdal is a simple drug. The same applies to Thorazine (chlorpromazine), Haldol (haloperidol), and Invega (AKA predigested Risperdal). If you’ve tried the broad-spectrum antipsychotics (Zyprexa (olanzapine), Seroquel, (quetiapine), Geodon/Zeldox? (ziprasidone), Clozaril (clozapine) or Saphris (asenapine)), and they didn’t work - as in they weren’t effective, and not that their efficacy was overwhelmed by sucking so hard - Risperdal probably won’t either. Unless it was a question of maxing out the dosage, in which case Risperdal or some of the old-school drugs like fluphenazine. If Risperdal is the first med your doctor suggests, go for it!
The odds Risperdal (risperidone) will work for bipolar mania are pretty good as far as antipsychotics go. If you tend to get dysphoric manias and/or mixed states, where you want to smash everything in sight, instead of euphoric manias, Risperdal might become your best friend.
For schizophrenia Ortho-McNeil-Janssen recommends starting at 2mg a day, increasing the dosage by 1–2mg a day until you reach 4mg a day. If needed, keep increasing the dosage until you reach 8mg a day. Once stable you can adjust your dosage as required with a range of 4–16mg a day.
For bipolar disorder Ortho-McNeil-Janssen recommends starting at 2–3mg a day, increasing the dosage by 1mg a day until you reach the target dosage of 1–6mg a day. Once stable you can adjust your dosage as required with a range of 1–6mg a day.
I don’t think I’m crazy enough to understand their math.
The dosages we suggest depend on how crazy you are at the time and if you’re already taking something. If you’re not too crazy and/or already taking something, try 0.25 - 0.5mg and increase by 0.25mg every 2–4 days. If very crazy, go with Janssen’s schedule. Especially if “very crazy” means the person who needs to take the Risperdal is not reading this because they are hospitalized.
Your doctor should be recommending that you reduce your dosage by 0.25 or 0.5mg a day every 4 to 5 days, if not more slowly than that. Like all antipsychotics, you can stop taking it all at once in an emergency situation (e.g. a life-threatening allergic reaction), but you should do that only under a doctor’s supervision.
Stops the rage induced by a dysphoric mania or mixed state like nothing else, in anywhere from an hour to the next day, without necessarily having to knock you out.
Other than the fact it’s working you can’t even tell you’re taking it for most applications.
While its side effect profile is low at the low dosages, at the dosages required to treat the primary approved applications - schizophrenia and bipolar - it frequently does a number on your hormones. The rates for EPS & TD are higher than some standard antipsychotics.
Risperdal is one of those drugs where the med you take isn’t the substance that does anything. Risperdal is metabolized by your liver to create the drug that actually does something, and that drug is available as Invega.
Leaky tits. Young or old, male or female, anyone taking Risperdal, especially more than 4mg a day, has a good chance of lactating.
In-Depth Pros & Cons
The usual: headache, nausea, dry mouth, constipation, sleepiness and lethargy or insomnia and way too much energy. Most everything of these go away within a couple of weeks, although the sleep & lethargy or insomnia & being wired may take a little longer.
Loss of libido, other sexual dysfunctions, swollen breasts, unexpected lactation (it’s especially unexpected when it happens to guys) and all sorts of other stuff related to increased prolactin and other hormonal wackiness.
The AP-induced movement disorders, especially tardive dyskinesia (TD) and extrapyramidal symptoms (EPS). Risperdal is currently known as the worst AAP, and one of, if not the worst AP in general when it comes to movement disorders.
Those all seem to be dosage-related, so the higher the dosage the more likely / worse they’ll be.
Also heart palpitations, tachycardia and other cardiac weirdness
Rabbit Syndrome. Duck syndrome! Rabbit syndrome! Duck syndrome! Sorry.
Plus discolored feces, and increased pigmentation.
Side Effect Details. TMI at times.
Having the highest rate of movement disorders such as TD & EPS of any atypical antipsychotic (although my money’s on Saphris eventually claiming that title).
Half-life: 21 hours clearance: 4–6 days
Pharmacokinetics Information Overload
Half-life is the average time it takes for you to process half of the drug’s active ingredient. If a drug has a half-life of around 24 hours and you take a dose of 100mg, you’ll have roughly the equivalent a 50mg dose after one day, a 25mg dose after two days, and so on. The rule of thumb is: multiply the half-life by five and you get how long it is for the dose you took to be cleared from your bloodstream, so there’s nothing swimming around to attach itself to your brain and start doing stuff1. That’s called “plasma clearance.” Complete clearance is a complex equation based on a lot of factors which may or may not: be published in the PI sheet, include personal data like your weight, or even completely figured out by corporate and independent researchers. It usually winds up being 2–5 days after plasma clearance no matter what2, but can take weeks. Sometimes a drug will clear from your brain and other organs before it clears from your blood. If we’ve found the complete clearance, or how to calculate it if it requires things like your weight and what your piss looks like, you’ll find that on the pharmacokinetics page.
the current best guess at any rate
Risperdal is sort of like Haldol (haloperidol) on steroids, and is a potent antagonist of the the serotonin 5HT2A serotonin, D2 dopamine, alpha-1 and alpha-2a noradrenergic, and H1 histaminergic receptors. It is also a moderate antagonist for the 5HT1, 5HT5, and 5HT7 serotonin, and the alpha-2b and alpha-2c noradrenergic receptors. The broad swath of serotonin or norepinephrine action helps to explain why Risperdal is helpful for rage. The potent D2, along with 5HT2A and norepinephrine/noradrenergic blockades explain why Risperdal will give you porno boobs and make you shake like epileptic marionette.
More than You Probably Ever Wanted to Know about How a Drug Works. AKA risperidone mechanism/method of action, or pharmacodynamics.
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I love Risperdal, and I miss taking it. I still keep some around for emergencies. And if worse came to worst, I’d take it again, TD be damned. I’d rather permanently look like an owl blinking Morse code, and whose tongue is sending out its own lewd messages, than deal with the crazy I went through in 2002.
An overall zero-to-five rating is absolutely useless information regarding medications. It is little more than a purely emotional and subjective value judgment on a med that has no bearing on how effective a drug is or, more importantly, if it is the right drug for you. So why do I have it? Mainly because it’s cathartic for anyone who is taking or has taken a drug3. Love it? Hate it? Here’s your chance to let everyone know. You don’t need to be a forum member or anything like that. You get all of one vote which can’t be changed, so make sure it’s what you want.
Get all judgmental about Risperdal (risperidone)
Rating 2.9 out of 5 from 22 criticisms
Vote Distribution: 6 – 0 – 2 – 3 – 4 – 7
Extended Comments As if I didn’t go on long enough here.
It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.
If you have any questions about Risperdal (risperidone), please see the Crazy Meds’ discussion board. I rarely answer questions about meds via e-mail.1 Based on Julien's calculations from A Primer of Drug Action, the half-life multiplied by five is the generally accepted estimate of how long it takes a single dose of any given drug to be eliminated from the blood stream/plasma of someone with a normal metabolism. That's also the rough estimate for steady stage if they can't get, or won't provide a number for that.
2 For crazy meds. I have no idea what the average complete clearance is for other types of medications. For all I know there are drugs that utterly vanish from your system in under five passes, and others that won't let go of your squishy bits for years after you stop taking them.
3 At some point I may have multiple one-to-ten ratings for individual aspects of medications, such as efficacy and side effects. That could be potentially useful.
4 These include: Canada's Product Monographs (PM), New Zealand's Medicine Data Sheets (MDS), the EU's European Public Assessment Reports (EPAR), and the Summary of Product Characteristics (SPC) used in Britain, Ireland, and many other places.
|Date created Tuesday, 08 March 2011 at 14:08:23||Page Author: JerodPoore||Last modified on Thursday, 05 December, 2013 at 05:28:44 by some med critic.|
Risperdal is a trademark of someone else. Look on the the PI sheet or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?
[begin rant] I rent a dedicated server for Crazy Meds. It’s sitting on a rack somewhere in Southern California along with a bunch of other servers that other people have rented. The hardware is identical, but no two machines have exactly the same operating systems. I don’t even need to see what is on any of the others to know this. If somebody got their server at the exact same time, with the exact same features as I did, I’m confident that there would be noticeable differences in some aspects of the operating systems. So what does this mean? For one thing it means that no two computers in the same office of a single company have the same operating system, and the techs can spend hours figuring out what the fuck the problem could be based on that alone. It also means that application software like IP board that runs the forum here has to have so many fucking user-configurable bells and whistles that even when I read the manual I can’t find every setting, or every location that every flag needs to be set in order for a feature to run the way I want it to run. And in the real world it means you can get an MBA not only with an emphasis on resource planning, but with an emphasis on using SAP - a piece of software so complex there are now college programs on how to use it. You might think, “But don’t people learn how to use Photoshop or Adobe Illustrator in college?” Sure, in order to create stuff. And in a way you’re creating stuff with SAP. But do you get a Bachelor of Fine Arts degree with an emphasis on Photoshop?
Back in the Big Iron Age the operating systems were proprietary, and every computer that took up an entire room with a raised floor and HVAC system, and had less storage and processing power than an iPhone, had the same operating system as every other one, give or take a release level. But when a company bought application software like SAP, they also got the source code, which was usually documented and written in a way to make it easy to modify the hell out of it. Why? Because accounting principles may be the same the world over, and tax laws the same across each country and state, but no two companies have the same format for their reports, invoices, purchase orders and so forth. Standards existed and were universally ignored. If something went wrong it went wrong the same way for everyone, and was easy to track down. People didn’t need to take a college course to learn how to use a piece of software.
I’m not against the open source concept entirely. Back then all the programmers read the same magazines, so we all had the same homebrew utilities. We even had a forerunner of QR Code to scan the longer source code. Software vendors and computer manufacturers sponsored conventions so we could, among other things, swap recipes for such add-ons and utilities. While those things would make our lives easier, they had nothing to do with critical functions of the operating system. Unless badly implemented they would rarely cause key application software to crash and burn. Whereas today, with open source everything, who the hell knows what could be responsible some part of a system failing. [/end rant]