side effects, dosage, reviews, how to take & discontinue, uses, pros & cons, and more
Table of Contents (hide)
- 1. Other brand names & branded generic names1
- 2. FDA Approved Uses of Remeron (mirtazapine)
- 3. Off-Label Uses of Remeron (mirtazapine)
- 4. Remeron’s (mirtazapine’s) pros and cons
- 5. Remeron’s (mirtazapine’s) Side Effects
- 6. Interesting Stuff Your Doctor Probably Won’t Tell You about Remeron (mirtazapine)
- 7. Remeron’s (mirtazapine’s) Dosage and How to Take Remeron (mirtazapine)
- 8. How Long Remeron (mirtazapine) Takes to Work
- 9. How to Stop Taking Remeron (mirtazapine)
- 10. Remeron’s (mirtazapine’s) Half-Life & Average Time to Clear Out of Your System
- 11. Days to Reach a Steady State
- 12. Shelf life
- 13. How Remeron (mirtazapine) Works
- 14. Comments
- 15. Your Ratings & Reviews of, Comments About, and Experiences with Remeron (mirtazapine), and More
- 16. Bibliography
|US brand name: Remeron|
|Generic name: mirtazapine|
Other Forms: You might be able to get it in pill form. These days Remeron SolTab - the orally disintegrating tablet - is the main way Remeron (mirtazapine) is prescribed and dispensed.
1. Other brand names & branded generic names1
- Avanza (Australia)
- Axit (Australia)
- Mirtabene (Austria)
- Remergon (Belgium)
- Norset (France)
- Remergil (Germany)
- Mirtaz (India, Sri Lanka)
- Rexer (Spain)
- Zispin SolTab (United Kingdom, Ireland)
Major depressive disorder
- Sleep Disorders
- Bipolar Depression
- And all sorts of things that keep you from sleeping well, like
- Chronic Fatigue
- Irritable Bowel Syndrome
- If serotonin and/or norepinephrine are the answer for you, Remeron will pull you out of the deepest, blackest depression like no other medication will.
- Remeron may not be as good as Seroquel or Zyprexa for knocking you out, but it’s better than trazodone for the combination of depression and insomnia.
- You may literally eat sugar straight out of the bag to satisfy your cravings for sweet carbohydrates. By “literally” I mean I have received e-mails from, and read reports by, people who have done exactly that.
- You may sleep too well.
- Has one of the highest poop-out (tachyphylaxis) rates of any med, antidepressant or otherwise.
Most of the anticholinergic effects common with psychiatric medications (e.g. constipation, confusion, loss of coordination, memory loss) are infrequent with Remeron. Instead you get intense hunger for the wrong foods, and with that comes weight gain, dry mouth and constipation caused by what you eat and not Remeron itself. Then you want to sleep a lot. It’s like you may as well be smoking pot when you take Remeron.
Edema, dizziness, low blood pressure, increased thirst to go with the munchies, ‘flu-like symptoms.
Going deaf and various flavors of herpes. Yeah, right, it was the Remeron that gave someone that STD. (See this review for how the herpes thing really works.)
Remeron also carries a warning for agranulyocytosis, the severe reduction in white cell count, along with fever, infection and all that fun stuff. That hit Mouse like a ton of bricks. She was stuck in a motel in Fairfield for a week after one dose of Remeron.
- Remeron appears to be subject to a really quick poop-out, like after just a month or so. Works great, then quits on you.
- Remeron will make you more drunk. So while liquor as no effect upon Remeron, the opposite is not true. Be extra careful if you mix booze and Remeron.
The initial dose of Remeron is 15mg. If no improvement is felt within two weeks, that may be increased to 30mg. If you’re still not feeling better a month after that, you can go up to 45mg and officially that’s it, although there are reports of some psychiatrists experimenting with doses up to 90mg. There are no other published dosage options for Remeron at this time, it’s just weird that way. 15, 30 or 45mg. Some of the more enlightened doctors are starting their patients at 7.5mg and titrating them in 7.5mg increments, and I’m all for that method. If I were you, and I got along with meds that messed with my serotonin, I’d insist on that. 7.5mg to start, up to 15mg after a week or two if no improvement, then 22.5mg after a month and so forth up to 45mg. I think the 90mg craziness is in response to Remeron poop-out, which is just exposing people to side effects for no good reason.
- For depression: one to two weeks.
- For sleep: usually the night you take your first dose, the second night at the latest. If Remeron doesn’t make you tired at 15mg a night, don’t bother.
Your doctor should be recommending that you reduce your dosage by 7.5 - 15mg a day every week if you need to stop taking it, if not more slowly than that. Based on the 20–40 hour half-life.
Mirtazapine’s half-life is 20–40 hours. The average is 26 hours for guys and 37 hours for girls. Girls always take longer. So Remeron is out of a guy’s system in about five days while it’s out of a girl’s in about seven days.
Half-life is the average time it takes for you to process half of the drug’s active ingredient. If a drug has a half-life of around 24 hours and you take a dose of 100mg, you’ll have roughly the equivalent a 50mg dose after one day, a 25mg dose after two days, and so on. The rule of thumb is: multiply the half-life by five and you get how long it is for the dose you took to be cleared from your bloodstream2, so there’s nothing swimming around to attach itself to your brain and start doing stuff. That’s called “plasma clearance.” Complete clearance is a complex equation based on a lot of factors which may or may not: be published in the PI sheet, include personal data like your weight, or even completely figured out by corporate and independent researchers. It usually winds up being 2–5 days after plasma clearance no matter what3, but can take weeks. Sometimes a drug will clear from your brain and other organs before it clears from your blood.
Steady state is the flipside of half-life. This is when you can expect to get over side effects caused by fluctuating amounts of a medication in your bloodstream. Often, but not always the same amount of time as the plasma clearance above.
Remeron is a somewhat unique med in the way it works. It directly increases the amount of serotonin your brain produces, and indirectly does the same for norepinephrine. It also speeds up the rate at which those neurotransmitters hit their receptors. Stahl calls that stepping on the accelerator and cutting the brakes. I think of it more like having your brain sit in a jacuzzi instead of marinating for longer like Cymbalta and Effexor would do. Plus Remeron focuses most of the serotonin action on 5TH1A receptors, blocks 5HT2A, 5HT2C & 5HT3, and is a potent antihistamine. In English: That’s why it’s a super-effective antidepressant/antianxiety med and sleeping pill that can poop-out quickly and literally make you eat sugar right out of the bag.
At any dosage it will make you crave doughnuts. Seriously. You will want to invest in Krispy Kreme stock (or maybe something along similar lines that isn’t tanking); as Remeron’s antagonism of the serotonin 5HT2C and H1 receptors gives you the munchies for carbohydrates and sugars like you were 16 and smoking the best pot ever in the parking lot of a strip mall with a 24-hour doughnut shop beckoning you with glazed and jelly-filled ecstasy. People dipping spoons into a bag of sugar and eating it as is - not unheard of when on Remeron. This stuff is nothing more than legal marijuana, and if I knew crap about biochemistry I could probably prove that crazy statement. From a purely molecular-chemical perspective THC and mirtazapine are nothing alike. But there’s just something about how the two drugs work that is really close. And people who have self-medicated with pot respond really well to meds that really push the norepinephrine, and hard. Strattera, reboxetine, Cymbalta, and the more potent TCAs. And Remeron.
The production of extra serotonin and norepinephrine, and not just soaking neurons in what neurotransmitters are available for a longer period of time, is sometimes the best solution to recalcitrant depression. When it works it makes people feel really good. I mean really good. Remeron is the closest thing to a happy pill on the market. Until you get all bummed out about how much weight you’ve put on and how little you do because you’re sleeping all the time.
As Remeron encourages your brain to actually produce more of the neurotransmitters serotonin and norepinephrine, talk to your doctor about taking their respective precursors, 5-HTP (or l-tryptophan) and l-tyrosine. Neurotransmitter/monoamine depletion is a controversial hypothesis, but it explains too many things, like antidepressant poop-out (tachyphylaxis) to dismiss outright.
Remeron is not for mild to moderate depression, it’s for people who are seriously depressed, who are willing to put up with the weight gain and the sleeping because those side effects suck much less than the dark pit of depressive despair one finds oneself in.
You probably don’t want to mix Remeron with Zyprexa as your choice of antipsychotic and antidepressant to treat bipolar disorder or severe treatment-resistant depression. One woman I know from the bipolar support forum on about.com was prescribed that combination as an inpatient in a Canadian hospital. She reported there how she ballooned up in weight, from 103 pounds to 162 pounds, in about six weeks, and carrying that on a 5′ 1″ frame. She gained a pound and a half a day, eating hospital food!
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An overall zero-to-five rating is absolutely useless information regarding medications. It is little more than a purely emotional and subjective value judgment on a med that has no bearing on how effective a drug is or, more importantly, if Remeron (mirtazapine) is the right drug for you. So why do I have it? Mainly because it’s cathartic for anyone who is taking or has taken Remeron (mirtazapine)4. Love it? Hate it? Here’s your chance to let everyone know. You don’t need to be a forum member or anything like that. You get all of one vote which can’t be changed, so make sure it’s what you want.
Get all judgmental about Remeron (mirtazapine)
Rating 3.3 out of 5 from 76 criticisms
Vote Distribution: 13 – 3 – 4 – 8 – 23 – 25
For various technical and page design reasons I had to move the actual reviews to their own page. While anyone can read the reviews, only registered members of the Crazy Meds Talk forum can write them.
It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.
If you have any questions about Remeron (mirtazapine), the best place to ask them is on the Crazy Meds’ Remeron (mirtazapine) discussion board.
Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Third edition by Stephen M. Stahl © 2008 Published by Cambridge University Press.
The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition by Stephen Stahl © 2009 Published by Cambridge University Press.
Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series) © 2007 An imprint of Elsevier. Also the 2004 edition, but only on pages that haven’t been fully updated yet.
Instant Psychopharmacology 2nd Edition Ronald J. Diamond MD © 2002. Published by W.W. Norton
The Complete Guide to Psychiatric Drugs Edward Drummond, MD © 2000. Published by John Wiley & Sons, Inc.
Healing Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, M.D. © 2003. Published by G.P. Putnam’s Sons.
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.
2 Based on Julien's calculations from A Primer of Drug Action, the half-life multiplied by five is the generally accepted estimate of how long it takes a single dose of any given drug to be eliminated from the blood stream/plasma of someone with a normal metabolism. That's also the rough estimate for steady stage if they can't get, or won't provide a number for that.
3 For crazy meds. I have no idea what the average complete clearance is for other types of medications. For all I know there are drugs that utterly vanish from your system in under five passes, and others that won't let go of your squishy bits for years after you stop taking them.
4 At some point I may have multiple one-to-ten ratings for individual aspects of medications, such as efficacy and side effects. That could be potentially useful.
|Date created Monday, 25 April, 2011 at 12:42:19||Page Author: JerodPoore||Last modified on Friday, 06 December, 2013 at 15:20:44 by some med critic.|
Remeron is a trademark of someone else. Look on the the PI sheet or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?
[begin rant] I rent a dedicated server for Crazy Meds. It’s sitting on a rack somewhere in Southern California along with a bunch of other servers that other people have rented. The hardware is identical, but no two machines have exactly the same operating systems. I don’t even need to see what is on any of the others to know this. If somebody got their server at the exact same time, with the exact same features as I did, I’m confident that there would be noticeable differences in some aspects of the operating systems. So what does this mean? For one thing it means that no two computers in the same office of a single company have the same operating system, and the techs can spend hours figuring out what the fuck the problem could be based on that alone. It also means that application software like IP board that runs the forum here has to have so many fucking user-configurable bells and whistles that even when I read the manual I can’t find every setting, or every location that every flag needs to be set in order for a feature to run the way I want it to run. And in the real world it means you can get an MBA not only with an emphasis on resource planning, but with an emphasis on using SAP - a piece of software so complex there are now college programs on how to use it. You might think, “But don’t people learn how to use Photoshop or Adobe Illustrator in college?” Sure, in order to create stuff. And in a way you’re creating stuff with SAP. But do you get a Bachelor of Fine Arts degree with an emphasis on Photoshop?
Back in the Big Iron Age the operating systems were proprietary, and every computer that took up an entire room with a raised floor and HVAC system, and had less storage and processing power than an iPhone, had the same operating system as every other one, give or take a release level. But when a company bought application software like SAP, they also got the source code, which was usually documented and written in a way to make it easy to modify the hell out of it. Why? Because accounting principles may be the same the world over, and tax laws the same across each country and state, but no two companies have the same format for their reports, invoices, purchase orders and so forth. Standards existed and were universally ignored. If something went wrong it went wrong the same way for everyone, and was easy to track down. People didn’t need to take a college course to learn how to use a piece of software.
I’m not against the open source concept entirely. Back then all the programmers read the same magazines, so we all had the same homebrew utilities. We even had a forerunner of QR Code to scan the longer source code. Software vendors and computer manufacturers sponsored conventions so we could, among other things, swap recipes for such add-ons and utilities. While those things would make our lives easier, they had nothing to do with critical functions of the operating system. Unless badly implemented they would rarely cause key application software to crash and burn. Whereas today, with open source everything, who the hell knows what could be responsible some part of a system failing. [/end rant]