Highlighting uses, dosage, how to take and discontinue


Paxil’s Side Effects, Warnings, etc. >>

Brand & Generic Names; Drug Classes

US brand name: Paxil
Generic name: paroxetine

Drug Class(es)

Primary drug class: Antidepressants
Additional drug class(es): Anxiolytics/Anti-anxiety Serotonin-Selective Reuptake Inhibitors

Approved & Off-Label Uses (Indications)

Paxil’s US FDA Approved Treatment(s)

Immediate-Release Paxil (paroxetine) Indications:

  • Major Depressive Disorder (MDD)
  • Panic Disorder
  • Social Anxiety Disorder
  • Obsessive-Compulsive Disorder (OCD)
  • Generalized Anxiety Disorder (GAD)
  • Posttraumatic Stress Disorder (PTSD)

Paxil CR (controlled-release paroxetine) Indications:

  • Major Depressive Disorder (MDD)
  • Panic Disorder
  • Social Anxiety Disorder
  • Premenstrual Dysphoric Disorder (PMDD)

Uses Approved Overseas but not in the US

Off-Label Uses of Paxil

Anxiety Spectrum Disorders

Miscellaneous Common/Significant Off-Label Uses

  • Headaches
  • Irritable Bowel Syndrome (IBS)
  • Tourette Syndrome
  • Premature ejaculation (I wonder why)

Less Common Off-Label Uses

When & If Paxil Will Work

Paxil’s Usual Onset of Action (when it starts working)

Like all SSRIs two-to-four, sometimes even six weeks.

Likelihood of Working

That all depends on what you’re taking it for. It’s not really that great of an antidepressant, but a pretty decent med for the alphabet soup of anxiety and is especially good for GAD, SAnD (though not as good as Zoloft), PMDD, and panic disorders without agoraphobia.

Taking and Discontinuing

How to Take Paxil

Immediate Release (IR)

The initial dosage is 10mg for Panic Disorder and 20mg for everything else. For GAD, PTSD, and Social Anxiety Disorder 20mg a day is the target dosage. For OCD and Panic Disorder it’s 40mg a day. There is no target dosage for MDD, just a maximum of 50mg a day and that 30mg a day was the average effective dosage in the clinical trials.

The dose is increased 10mg a day per week, until you reach the target dosage and/or something that works. You take it once a day, usually in the morning.

Controlled release (CR)

The initial dosage is 25mg a day for MDD, 12.5mg a day for everything else. The is no target dosage for any condition, which is highly unusual, albeit extremely sane for any crazy med. The maximum dosages are: 62.5mg a day for MDD, 75mg a day for Panic Disorder, 37.5mg a day for Social Anxiety Disorder, and 25mg a day for PMDD.

We at Crazymeds suggest starting at 5–10mg (IR) or 12.5mg (CR) a day for everything, and increasing by 5–10/12.5 mg a day per week only if you need to.
Unless SSRIs usually keep you awake, we suggest you should first try taking it at night.

How to Stop Taking Paxil (discontinuation / withdrawal)

Very, very slowly and very, very carefully. Regardless of how quickly you increased your dosage (titrated), the tapering (discontinuation schedule) we suggest is at the same rate as our suggested titration: 5–10mg a day per week for the immediate release form and 12.5mg a day per week for the controlled release form. So if you’re taking 37.5mg a day of Paxil CR you should take 25mg a day one week, 12.5mg a day the next week, and with any luck you should be OK to stop taking it all together by the end of week two. While most people should have only mild, if any, discontinuation symptoms using that schedule, plenty of people will still have problems. Before you begin, talk to your doctor about a short prescription of 5 & 10 mg IR tablets even if you take Paxil CR, and a week’s worth of Prozac.

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Last modified on Sat, 27 Jun, 2015 at 17:49:58 by JerodPoorePage Author Date created April 08, 2011, at 05:11 PM
“Paxil (paroxetine ): Uses and Using” by Jerod Poore is copyright © 2011 Jerod Poore Published online 2011/04/08

Paxil, and all other drug names on this page and used throughout the site, are the trademarks of someone else.

will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

Page design and explanatory material by Jerod Poore, copyright © 2003 - 2015. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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