approved indications and clinically-significant off-label uses, as well as experimental and failed applications

> Lexapro Approved and Off Label Uses


Brand and Generic Availability | Lexapro Index | How Long & How Likely To Work, Comparisons with Other Meds
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Psychopharmacological Need for Approval

Drugs are officially approved to be used for certain things, and they may be approved for one thing in one country but something else entirely in another.1

Meds are often prescribed for conditions (e.g. Topamax for bipolar disorder), or people (e.g. adolescents being prescribed any SSRI or SNRI except Prozac or Lexapro) they aren’t approved to treat. This is known as off-label prescribing. Some off-label prescribing is so common that lots of people think the medication is a first-line treatment for the condition it’s prescribed to treat (e.g. Trileptal for bipolar disorder). If a drug company’s sales force (a.k.a. pharm reps) is too aggressive in pushing a med for off-label applications where it doesn’t work as well as people think, the FDA will now come down hard on them (e.g. Novartis getting heavily fined for promoting Trileptal as a treatment for bipolar disorder).

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Off-label prescribing is not necessarily bad. Drugs that almost, or would almost, pass a clinical trial for some indication still work for a lot of people. As long as the reason for not clearing the hurdles of phase III clinical trials wasn’t the death of too many participants, or some other intolerable side effect.

Lexapro is US FDA-Approved to Treat:

  • Major depressive disorder (MDD) in adults
  • MDD in adolescents (Prozac is the only other modern antidepressant approved to treat MDD in adolescents)
  • Generalized anxiety disorder (GAD) in adults.

Lexapro (escitalopram) is Approved Elsewhere for:

* Everywhere else in the world where you find Lexapro / Cipralex / etc. (escitalopram), it’s approved to treat social anxiety disorder and panic disorder, with or without agoraphobia, along with MDD and GAD.
  • Cipralex / Lexapro is also approved to treat OCD in:
    • Argentina
    • Australia
    • Canada
    • Chile
    • Denmark
    • Sweden
    • Spain
    • New Zealand
    • the UK

Clinically Significant or Otherwise Common Off-Label Uses of Lexapro (escitalopram)

* Social anxiety disorder (SAnD) - it’s OK; sucking less than most other meds is Lexapro’s biggest advantage.
See the page on Lexapro’s efficacy for details on the likelihood Lexapro (escitalopram) will work for approved indications and off-label uses.

Just because a medication is approved or commonly prescribed for a particular condition doesn’t necessarily mean you should be taking it for that condition. There could be a drug that might be better to try first, or at least talk to your doctor about trying first, such as Topamax instead of Depakote as a daily med to prevent migraines (and Topamax has its own reasons why you should and should not take it). Or the condition you have isn’t bad enough to warrant medication at all. E.g. any antidepressant if you’re not so depressed that you can function at relatively the same level as you do when you’re not depressed.

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When/Why You Should Take Lexapro (escitalopram)

You haven’t tried any antidepressant before, you and your doctor both think you need one, your symptoms don’t scream Wellbutrin (anhedonia, unable to conceive on how to begin anything), but are still pretty bad and you need something to work sooner than later. And your insurance will pay for it.

When/Why You Should NOT Take Lexapro (escitalopram)

If Celexa didn’t work for you, or Celexa is working for you with side effects that really aren’t as bad as you think they are.

The only side effects that are less likely to be problems with Lexapro than Celexa are drowsiness and weight gain. The key phrase being less likely. The good news is switching back to Celexa if Lexapro doesn’t work for you is less likely to result in SSRI poop-out or becoming treatment-resistant when neither of those would have happened if you just stayed with Celexa. The bad news is “less likely to” does not equal “won’t.”

When all else fails and you’ve run out of other options, Lexapro may be your last best chance at treating an obscure or treatment-resistant condition.

Less Common/Experimental Off-Label Uses of Lexapro

* Impulsive-compulsive Internet Usage Disorder. IC-IUD is better known as “Internet addiction,” and it’s real. The big question is: if you found this page when searching for Internet addiction, Internet usage disorder, or something similar, do you have IC-IUD, cyberchondria, or both? And if it’s both, should you take a medication for it? Lexapro seems to help with IC-IUD, talk therapy combined with workbooks is still your best bet for cyberchondria.

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Be careful! Some off-label uses have been total fails, and otherwise safe meds can be downright dangerous when used for some things.
You probably want to avoid using Lexapro for the following:

Failed Off-Label Uses

  • Fear of public speaking. When you have no brain cooties. It didn’t just fail, Lexapro made it worse! Why someone thought taking an SSRI as required would be a good idea is beyond me. But either they don’t know how to write an abstract, or how SSRIs work, as the conclusion contradicts the title.
  • Kleptomania. In all fairness, nothing seems to work for kleptomania. A woman who was in the lock ward with me had been undergoing ECT for a month to treat kleptomania, and she was still stealing stuff.

Potentially Dangerous Off-Label Uses

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References

Lexapro (escitalopram) Full US Prescribing Information

Novartis Pharmaceuticals Corporation to Pay $422.5 Million for Off-Label Drug Marketing Food and Drug Administration Office of Criminal Investigations September 30, 2010 Last accessed 02 July 2014.

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Brand and Generic Availability | Lexapro Index | How Long & How Likely To Work, Comparisons with Other Meds


1 Before Cymbalta (duloxetine) was approved as an antidepressant in the US it was already approved in the EU, but only for stress urinary incontinence and sold under the trade name Yentreve. Duloxetine is now sold in the EU as an antidepressant under the trade name Cymbalta.
A better known, if slightly different example is bupropion. According to the 2007 edition of Mosby's Drug Consult, and my highly-skilled Google-fu, in the US, Canada and Singapore you can get both Wellbutrin (bupropion) as an antidepressant or as Zyban (bupropion) to stop smoking. In Korea, Thailand and most of South America (but not Brazil) you can get bupropion (under various trade names) only as an antidepressant. In Brazil, the EU & UK, Israel, India, Australia and New Zealand it's only available as Zyban to help you stop smoking.


If you have any questions not answered here, please see the Crazymeds Lexapro discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher crazymeds.us


Last modified on Wednesday, 25 September, 2013 at 11:07:30 by JerodPoorePage Author Date created
“Lexapro Approved and Off Label Uses” by Jerod Poore is copyright © Jerod Poore Published online 2010/12/05
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Lexapro, and all other drug names on this page and used throughout the site, are a trademark of someone else.

will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.




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Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
Crazymeds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore


1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas? I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

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