Table of Contents (hide)
- 1. Brand & Generic Names; Drug Class
- 2. What is Lamictal (lamotrigine) Used For?
- 3. When Will Lamictal (lamotrigine) Start Working?
- 4. Will Lamictal Really Work for What You Have?
- 5. How to Take Lamictal (lamotrigine)
- 6. How to Stop Taking Lamictal (lamotrigine)
- 7. Lamictal (lamotrigine) Pros and Cons
- 8. Lamictal (lamotrigine) Side Effects
- 9. What You Really Need to be Careful About with Lamictal (lamotrigine)
- 10. Lamictal (lamotrigine) Half-Life & How Long Until Lamictal Clears Your System
- 11. How Lamictal (lamotrigine) Works
- 12. Comments, Lamictal PI Sheet, and More
Lamictal (lamotrigine) highlights: side effects, dosage, reviews, how to take & discontinue, uses, etc. The “More…” links are to pages with greater detail. The Comprehensive Lamictal pages have all information from all the “More about…” pages, but with less explanatory material.
§1. Brand & Generic Names; Drug Class
|US brand name:||Lamictal|
|What is Lamictal (lamotrigine)?|
|Lamictal (lamotrigine) is in the AntiepilepticDrugs/Anticonvulsants class of drugs.|
§2. What is Lamictal (lamotrigine) Used For?
§2.1 US FDA Approved Treatment(s)
Bipolar disorder 1 - maintenance treatment. Epilepsy - by itself or with other meds, for adults & children.
§2.2 Popular Off-Label Uses
§3. When Will Lamictal (lamotrigine) Start Working?
For epilepsy Lamictal (lamotrigine) usually begins to work whenever you get in the neighborhood of 200–400mg a day.
If you’re in the depressed phase of bipolar disorder, Lamictal (lamotrigine) can work within two-four days of your first 25mg. The average dosage that works for depression is 100mg, and it typically takes 2–4 weeks to reach that dosage.
For mania/true mood stabilization the average therapeutic dosage is around 150–200mg a day. But, like everything else about Lamictal (lamotrigine), it depends. This one is a lot harder to nail down, but a month is the closest thing to an average that we have.
§4. Will Lamictal Really Work for What You Have?
The odds are decent that Lamictal will work for epilepsy, especially if you follow the PI sheet and add it to, or convert from another AED.
§4.2 Bipolar 2
Lamictal (lamotrigine) is generally considered to be the best drug on the market for bipolar 2. While there are always conflicting data, your mileage may vary, yadda yadda yadda, with its track record efficacy and other factors, Lamictal (lamotrigine) should be the first med used by many, if not most people diagnosed with bipolar 2.
§4.3 Bipolar 1
If you take Lamictal like the FDA tells you to - after being stable on another med - the chances are pretty good you’ll stay stable.
§5. How to Take Lamictal (lamotrigine)
Lamictal has the most complicated dosing instructions and schedules1 to increase the dosage (titration) of any crazy med. They take up 9 pages of the PI sheet. You need to look at the expanded dosing and titration page, as there’s no way to easily explain it.
§6. How to Stop Taking Lamictal (lamotrigine)
According to GSK: “Lamictal should be tapered over a period of at least 2 weeks (approximately 50% reduction per week).” Our rule of thumb: decrease the dosage at the same rate you increased it. Otherwise as slowly as you can. 25–50mg a day every week until you’re down to 100mg a day, then 25mg a day per week. If you have to stop due to a really serious side effect, such as SJS (Stevens-Johnson Syndrome, a.k.a. The Rash or the Lamictal rash), then you and your doctor (or whoever is in the emergency room) will have to figure out a faster schedule.
§7. Lamictal (lamotrigine) Pros and Cons
The best medication on the market to deal with bipolar depression without the risks of mania or lowering the seizure threshold associated with antidepressants. Weight neutral. One of the safest meds to use during pregnancy. The side effects suck less than the other meds with FDA approval for maintenance treatment of bipolar disorder.
That “without the risk of mania” is only after you’re taking enough. You might get a little too happy the first couple of weeks. Easily affected by drug-drug interactions, in spite of being metabolized in such a way that only a few meds should affect it. Can mess with your skin in all sorts of ways that could cause you to panic and stop taking it when you don’t have to.
§7.3 Interesting Stuff your Doctor Probably didn’t Tell You about Lamictal (lamotrigine)
Women have noticeably more side effects than men. Lamictal prescriptions have been filled with Lamisil. Why GSK gave them such similar names is beyond me.
§7.4 What Lamictal (lamotrigine) Is Best Known for
The Rash. Everyone is scared shitless of The Lamictal Rash.
Totally kicking the assess of Symbyax, Seroquel, and whatever other atypical antipsychotics with FDA approval to treat bipolar depression. Despite not having FDA approval to treat bipolar depression.
More pros, cons, and interesting stuff about Lamictal
§8. Lamictal (lamotrigine) Side Effects
§8.1 Typical Lamictal Side Effects
Rashes, photosensitivity, rashes, lethargy, rashes, insomnia, rashes, memory and cognitive problems, rashes, and headaches that are sometimes really bad. Did I mention rashes and assorted other skin problems? The rash thing is overblown, serious rashes aren’t all that common. Other skin problems, and mildly annoying, short-term rashes happen all the time. The Lamictal headache is usually temporary, and if you do get it, the odds are it will be when you change the dosage. The lethargy, and stupids usually diminish and may even go away, especially if you take folic acid. The insomnia is one of those side effects you’ll know is temporary as soon as it stops.
§8.2 Uncommon Lamictal Side Effects
A specific type of insomnia where you’re really sleepy but just can’t fall asleep. Muscle aches, everything from just a twinge in your neck or back to full-body aches that make you wonder if you were possessed by some spirit that made you participate in a triathalon the day before and have no memory of it. Similar to what you get with Topamax. Dry mouth. OCD-like symptoms. Don’t be surprised if you get anxious or have other hypomanic effects if taking it for bipolar disorder.
§8.3 Freaky Rare Lamictal Side Effects
Going deaf. Permanently.
Hiccups that won’t stop.
More Lamictal side effects
§9. What You Really Need to be Careful About with Lamictal (lamotrigine)
Stevens-Johnson Syndrome. AKA The (Lamictal) Rash.
More Lamictal black box and other warnings, pregnancy category, etc.
§10. Lamictal (lamotrigine) Half-Life & How Long Until Lamictal Clears Your System
Half-life: 25–32 hours, depending on all sorts of factors. And that’s the median average. Clearance: 6–8 days.
Drugs.com’s drug-drug and drug-food interaction checker
More Lamictal pharmacokinetics & noted drug-drug & drug-food interactions
Clearance given here is “plasma clearance,” or how long it takes to be out of your blood so there’s nothing swimming around to attach itself to your brain and start doing stuff. Complete clearance is a complex equation based on a lot of factors which may or may not be published in the PI sheet or even figured out by independent researchers. If we’ve found it and calculated it you’ll find that on the pharmacokinetics page.
§11. How Lamictal (lamotrigine) Works
the current best guess at any rate
Originally designed as a folate antagonist (like antimalarial drugs), Lamictal was thought to have one of the simplest mechanism of action of any AED, doing nothing else except inhibiting voltage-sensitive sodium channels and maybe having a little affect on sigma opioid receptors (which are now being studied for all sorts of things). Now it looks like it also inhibits gated sodium and calcium channels, maybe even potassium. It’s still one of the least GABAergic ACs around.
More about how Lamictal works. AKA Lamictal mechanism/method of action, or pharmacodynamics.
§12. Comments, Lamictal PI Sheet, and More
Antiepileptic drugs / anticonvulsants (AEDs / ACs) are generally a pain in the ass to take, and Lamictal is the biggest diva of them all. But Lamictal (lamotrigine) works, and works well, for two difficult-to-treat conditions: bipolar 2 featuring severe, near-constant depression that is usually misdiagnosed as a variant of unipolar depression, and Lennox-Gastaut syndrome. You may have to drastically alter your lifestyle and that of your entire family (e.g. no more perfume or scented cleaning products) to keep taking it without being covered in a scary-looking, but otherwise benign rash, but that sucks so much less than treatment-resistant bipolar 2 or watching your kid with Lennox-Gastaut hit the floor for the twentieth time today.
In spite of the climate of fear that permeates everything having to do with Lamictal (lamotrigine) due to The Rash, and loud complaints about killer headaches and full-body muscle aches, Lamictal actually has one of the lowest side effect profiles around. It’s not as low as Keppra’s but it is almost as low as Neurontin’s, with the added advantage of actually doing something for bipolar disorder and forms of epilepsy that are usually way too severe for Neurontin to handle. It may be the pickiest of all AEDs, but has been an absolute lifesaver for thousands of people.
More comments As if I didn’t go on long enough here.
Lamictal’s Full US Prescribing Information / PI Sheet
Consumer/patient comments about, reviews of, and experiences with Lamictal
If you have any questions about Lamictal (lamotrigine), please see the Crazy Meds’ Lamictal (lamotrigine) discussion board
Allegedly Useful Links. Mostly official sites we could find for this med, PI sheets from countries other than the US, and reviews from consumer review sites.
Date created January 18, 2011, at 15:16:23 Page Author: Jerod Poore Last edited by: Jerod Poore on November 12, 2012, at 05:34 PM
Lamictal is a trademark of someone else. Look on the the PI sheet or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing.
Page design and explanatory material by Jerod Poore, copyright © 2004 - 2013. All rights reserved.
Support Crazy Meds by
joining my doubleplusgood circle jerk adding me to your Google+ circle.
Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, and 2013 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and the following disclaimer, I’m usually cool with it.
All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on the Crazy Meds Forum.
The information on Crazy Meds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away.
Crazy Meds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
All brand names of the drugs listed in this site are the trademarks of the companies named on the PI/SPC sheet associated with the medication, sometimes on the pages about the drugs, even though those companies may have been acquired by other companies who may or may not be listed in this site by the time you read this. Or the rights to the drug were sold to another company. And any or all of the companies involved may have changed their names.
Crazy Meds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows XP3. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazy Meds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazy Meds is not responsible for whatever weird shit your browser does or does not do when you read this site2.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices or in all dimensions of reality.
‘Everything is true, nothing is permitted.’ - Jerod Poore
1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?
[begin rant] I rent a dedicated server for Crazy Meds. It’s sitting on a rack somewhere in Southern California along with a bunch of other servers that other people have rented. The hardware is identical, but no two machines have exactly the same operating systems. I don’t even need to see what is on any of the others to know this. If somebody got their server at the exact same time, with the exact same features as I did, I’m confident that there would be noticeable differences in some aspects of the operating systems. So what does this mean? For one thing it means that no two computers in the same office of a single company have the same operating system, and the techs can spend hours figuring out what the fuck the problem could be based on that alone. It also means that application software like IP board that runs the forum here has to have so many fucking user-configurable bells and whistles that even when I read the manual I can’t find every setting, or every location that every flag needs to be set in order for a feature to run the way I want it to run. And in the real world it means you can get an MBA not only with an emphasis on resource planning, but with an emphasis on using SAP - a piece of software so complex there are now college programs on how to use it. You might think, “But don’t people learn how to use Photoshop or Adobe Illustrator in college?” Sure, in order to create stuff. And in a way you’re creating stuff with SAP. But do you get a Bachelor of Fine Arts degree with an emphasis on Photoshop?
Back in the Big Iron Age the operating systems were proprietary, and every computer that took up an entire room with a raised floor and HVAC system, and had less storage and processing power than an iPhone, had the same operating system as every other one, give or take a release level. But when a company bought application software like SAP, they also got the source code, which was usually documented and written in a way to make it easy to modify the hell out of it. Why? Because accounting principles may be the same the world over, and tax laws the same across each country and state, but no two companies have the same format for their reports, invoices, purchase orders and so forth. Standards existed and were universally ignored. If something went wrong it went wrong the same way for everyone, and was easy to track down. People didn’t need to take a college course to learn how to use a piece of software.
I’m not against the open source concept entirely. Back then all the programmers read the same magazines, so we all had the same homebrew utilities. We even had the forerunner to QR Code to scan the longer source code. Software vendors and computer manufacturers sponsored conventions so we could, among other things, swap recipes for such add-ons and utilities. While those things would make our lives easier, they had nothing to do with critical functions of the operating system. Unless badly implemented they would rarely cause key application software to crash and burn. Whereas today, with open source everything, who the hell knows what could be responsible some part of a system failing. [/end rant]
HomePage → Meds → AntiepilepticDrugs/Anticonvulsants → Lamictal (lamotrigine) Overview → Lamictal (lamotrigine) Global & Generic Availability