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Two of the most important things to know when deciding on which med is the best for a particular condition2: how likely is it to work and how long will it take.

The odds of a med working for a particular condition and how long it generally takes to work should be fairly easy to nail down, and not need to be summed up by the Internet shorthand YMMV (Your Mileage May Vary). Aside from it being hard enough to get an accurate diagnosis when brain cooties are involved, why is it so difficult to figure out if BuSpar is right for you and how long it will take for you to know that?

  • Because no one is quite sure exactly what causes various conditions.
  • Which is further complicated when everything is a spectrum disorder (e.g. bipolar 1, bipolar 2, all the others planned for DSM-V).
  • And they’re never really sure about how BuSpar works in the first place.
  • Plus, if you have more than one condition for which you’re taking one or more medications to treat, things get really complicated.
  • None of which is helped by studies that produce contradictory results, if they aren’t questionable in the first place.3

Always remember: if your symptoms suddenly get a lot worse, call your doctor immediately. Any drug that makes your symptoms worse is a drug you probably need to stop taking as soon as possible.

See our page on the tests researchers use to measure the efficacy of medications, including during clinical trials to get FDA approval.

1.  How Long Until BuSpar (buspirone hydrochloride) Starts Working1

Because of the nonlinear pharmacokinetics, it’s hard to know when you should get an effect from BuSpar, but Bristol-Myers seems to think two to three days should be sufficient. Like most things that work on your serotonin, especially as this is likely to augment an antidepressant, I would make that two to three weeks to decide if BuSpar helping at all.

2.  How Effective BuSpar (buspirone hydrochloride) is for its Approved Uses

BuSpar seems to be immensely variable in how it hits people — even studies showing its effectiveness noticed this. Like most meds, it’s all a matter of hitting the right neurotransmitters in the right ways. But since it’s low on the side effects and non-addictive, it’s worth a stop on the med-go-round if you’re experiencing SSRI poop-out or inadequate relief of anxiety disorders with an SSRI.

3.  Likelihood BuSpar (buspirone hydrochloride) will Work for Off-Label Applications

4.  BuSpar (buspirone hydrochloride) versus Other Anxiolytics/Anti-anxiety for its Approved Indications

5.  How BuSpar (buspirone hydrochloride) Compares with Other Drugs for Off-Label Treatments

‹ Approved & Off-label Uses | BuSpar Index | How to Take and Discontinue ›
Crazy Meds Comprehensive BuSpar pages

Bibliography

1 In fancy doctorspeak: Time-to-response, or response time, or response begins at, or something with "response" in it. Sometimes "onset" is used, but "onset" usually refers to when the symptoms of a condition or side effect first appeared (presented).

2 Assuming you were correctly diagnosed in the first place.

3 Keep in mind that according to one study, most drug studies will skew in favor of the med made by the company that sponsored the study.* That's one of my favorite "no shit Sherlock" studies, although it did help in getting conflicts of interest showing up on papers.
Two additional papers along similar lines are Why Current Publication Practices May Distort Science** and Why Most Published Research Findings Are False***. So in addition to the books we use as source material, this is why we also factor a lot of anecdotal evidence (personal experience, experiences of people we know, case reports, what people have sent us in e-mail, and what is posted all over the Internet) into our conclusions regarding the likelihood of meds working, the prevalence of various side effects, etc.
While the drug companies are getting a lot more transparent and publishing more data in the PI sheets regarding the results of the clinical trials, they still don't publish how many times a drug failed a clinical trial.****


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