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> Edronax


US brand name: Edronax
Generic name: reboxetine

Class: Antidepressant. Specifically a Norepinephrine-Selective Reuptake Inhibitor (NSRI)

1.  Other brand names & branded generic names1

  • Norebox
  • Vestra
  • reboxetine mesilate (British Commonwealth spelling)

2.  FDA Approved Uses of Edronax (reboxetine)

Reboxetine isn’t approved for anything in the US. We have Strattera (atomoxetine) instead, which is approved to treat ADD/ADHD in the US. In commie In un-American Outside of the US in many places you’ll now find Strattera (e.g. Australia, Canada, Ireland, New Zealand and the UK) you’ll find reboxetine approved to treat depression-spectrum disorders, usually major depressive disorder (MDD).

3.  Off-Label Uses of Edronax (reboxetine mesylate)

4.  Edronax (reboxetine) pros and cons

4.1  Pros

It’s NSRI, which means:

  • Low side effect profile
  • No discontinuation syndrome like SSRIs and SNRIs
  • It’s less likely to trigger mania in the bipolar than SSRIs

4.2  Cons

It’s an NSRI, which means:

  • While the side effect profile may be low, one or more of the common side effects are more likely to hang around than is the case with an SSRI, SNRI, or TCA.
  • You can’t legally buy it in the US, and it’s a pain in the ass to legally import it for your own use.
  • Even if you can buy it, Edronax comes in one dosage: 4mg. Take it or leave it.
  • If you’re bipolar and aren’t stable, even stable in being depressed the same way for months, it’ll destabilize you further.
  • And it might be difficult to tell if reboxetine did trigger a mania after all, as one side effect of NSRIs is short-term euphoria without any other symptoms of mania. Making reboxetine and Strattera true “happy pills,” for a little while.

5.  Edronax (reboxetine) Side Effects

5.1  Typical Side Effects

The usual for NSRIs - headache, dry mouth, urinary hesitance, constipation, insomnia/early awakening. The headache tends to go away and only reappears with a dosage increase for most people. The urinary hesitance, dry mouth, constipation and insomnia and/or early awakening can be your constant companions or strike at random throughout the time you take it.

5.2  Not So Common Side Effects of Edronax (reboxetine)

Increased heart rate or heart palpitations. Getting really sweaty. Chills. Like Strattera (atomoxetine) the PI sheets list, and guys have reported temporary and permanent (for as long as you take it) sexual side effects ranging from painful ejaculation to erectile dysfunction. Read about a couple cases of more unusual problems below…

5.3  Freaky Rare Side Effects of Edronax (reboxetine)

This is almost as good as, and obviously related to, Savella’s freaky rare side effect (which is currently The. Best. Freaky Rare Side Effect. Ever.):
Reboxetine induced erectile dysfunction and spontaneous ejaculation during defecation and micturition [urination]. I can’t wrap my head around the concept of simultaneously pissing and coming, but this is an extremely rare as well as freaky side effect, so all you guys into water sports may as well forget about trying to get some reboxetine. If reboxetine is going to mess with your party-time plumbing™, it will probably be more like this guy’s story.

6.  Interesting Stuff Your Doctor Probably Won’t Tell You about Edronax (reboxetine)

Women may respond to SSRIs better than NSRIs, so this may not necessarily be the best route for girls.


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7.  Reboxetine’s Dosage and How to Take Edronax (reboxetine)

The recommended initial dose is 4mg twice a day. After three weeks it may be increased to 10–12mg total, however you want to divide your 2.5 to 3 tablets. The optimal dosage is in the range of 8–12mg a day.
As usual we disagree, and suggest starting at 4mg a day, divided in half (the pills are made to be split), maybe even 2mg once a day. Then increase by 2mg a day after two-three weeks as required.

8.  How Long Edronax (reboxetine) Takes to Work

An average of two weeks in a range of 10 to 30 days.

9.  How to Stop Taking Edronax (reboxetine)

It’s an NSRI, so if you have the luxury to taper, by all means do so. Reduce the dosage by 4mg a day every 3 days. But if you need to stop immediately, that’s usually not much of a problem. If you do quit cold turkey expect rebound symptoms, which may include panic attacks and short-lived euphoric or dysphoric mania.

10.  Reboxetine’s Half-Life & Average Time to Clear Out of Your System

With a half-life of 12–13 hours, reboxetine is usually cleared in 3–4 days.

11.  Days to Reach a Steady State

Five days.

12.  Shelf Life

3 years.

13.  How Edronax (reboxetine) Works

Based upon the Communications Interference Hypothesis of psychiatric and neurological conditions, or brain cooties, reboxetine effectively raises the norepinephrine levels in your brain by letting your synapses soak in norepinephrine for longer than usual by slowing (inhibiting) the mechanism of norepinephrine transmission deeper into the neurons (reuptake).

14.  Comments

I really wish I knew why drug companies didn’t make more norepinephrine-selective reuptake inhibitors (NSRIs). I know I’m not the only person to respond well to them. Let’s ask PubMed…

Reboxetine vs. Zoloft for MDD. Reboxetine was more effective. It may have sucked a little more, but it still worked better.

Reboxetine vs. Effexor They work equally well. Reboxetine is a little faster and, as above, sucks a little more. Although this study was far too brief to take into account having to stop taking either med.

OK, this one is super-specific, so I’m using the actual study title: Reboxetine versus fluvoxamine in the treatment of motor vehicle accident-related posttraumatic stress disorder: a double-blind, fixed-dosage, controlled trial.
Then again, it is an Israeli study, and a huge chunk of the population there has combat PTSD (which responds to meds and talk therapy differently) and similar forms, so I can understand the need for specificity. Reboxetine worked just as well but sucked more. Starting at 8mg a day.

Reboxetine vs. Celexa Celexa worked a little better and, except for sexual side effects, sucked less than reboxetine.

Along similar lines Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. Reboxetine and Prozac were equally effective, and Prozac sucked less, except for sexual side effects.

Somebody came up with the brilliant idea of treating depression-induced sexual dysfunction with Paxil. Not as some grasping at straws thing, but as a normal course of treatment. If you can get grant money for that then I really need to get better letters after my name. Reboxetine vs. Paxil for fixing sexual dysfunction & MDD. Seriously. Reboxetine wins. I imagine you’re shocked.

On the down side there is this meta-analysis: Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials, which basically says, “Reboxetine doesn’t do shit for depression. You’re better off with a placebo, or if you’re really depressed, take an SSRI.” The problem is, meta-analyses are like statistics, you can make them prove anything you want. What gets lost in the information overload are the people with niche depression spectrum conditions who don’t respond to serotonin-based treatments but do respond to norepinephrine-based treatments.

Reading all those studies makes it look as if Edronax isn’t worth exploring. Note what they all have in common: everyone started a 8mg a day. No wonder they were all hit with suck-ass side effects. At Crazymeds we’re all about start low, titrate slow, and no target dosage. However the overall responder rate is pretty small, and my best guess is somewhere that in the 10–15% range, 20% at the most, of people with a mood disorder need adjustment to norepinephrine alone, so SNRIs like Cymbalta (duloxetine) or the dopamine & norepinephrine reuptake inhibitor Wellbutrin (bupropion) would not be appropriate.

For some time the only NSRI available was either or both of Edronax (reboxetine) or viloxazine. Unless you have catalepsy, good luck with that viloxazine prescription. In Canada Strattera has gone off patent so, you can now get both generic atomoxetine and reboxetine in the Great White North. Both drugs are available as brand in the UK Ireland.

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15.  Edronax Ratings, Reviews, & Other Sites of Interest

Edronax Ratings & Reviews Page.

15.1  Rate Edronax

Give your overall impression of Edronax on a scale of 0 to 5. Detailed ratings and reviews are available on the Edronax Ratings & Reviews Page.

Get all critical about Edronax

4.5 stars Rating 4.3 out of 5 from 19 criticisms.
Vote Distribution: 0 – 0 – 0 – 1 – 7 – 11


15.2  Rate this article

If you’re still feeling judgmental as well as just mental2, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.

Get all judgmental about the Edronax (reboxetine) Synopsis

4 stars Rates 4.0 out of 5 from 11 value judgments.
Vote Distribution: 0 – 0 – 0 – 0 – 7 – 4



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15.3  Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, check for drug-drug interactions

Drugs.com’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.


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15.4  Discussion board

If you have any questions not answered here, please see the Crazymeds Edronax discussion board.



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16.  References

  1. Edronax (reboxetine) Full US Prescribing Information

The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition by Stephen Stahl

All those PIs/SPCs listed above.

1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.

2 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!


If you have any questions not answered here, please see the Crazymeds Edronax discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)


Last modified on Sunday, 23 March, 2014 at 14:07:59 by SomeMedCriticPage Author Date created
“Edronax (reboxetine): a Synopsis for the Educated Consumer.” by Jerod Poore is copyright © Jerod Poore Published online 2011/07/20
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Edronax, and all other drug names on this page and used throughout the site, are a trademark of someone else.

will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.




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Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



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All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
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Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

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3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas? I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

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