side effects, dosage, reviews, how to take & discontinue, uses, pros & cons, and more

> Edronax

Some Crazymeds mugs to help you wash down your antidepressants. Get mugged at Straitjacket T-shirts for more. 11oz $13 & 15oz $14
Depression Sucks! mugs at Straitjacket T-shirts
Depression Sucks! mugs
Captain Panic! mugs at Straitjacket T-shirts
Captain Panic! mugs
Mentally Interesting mugs at Straitjacket T-shirts
Mentally Interesting mugs
Fuck OCD mugs at Straitjacket T-shirts
Fuck OCD mugs

US brand name: Edronax
Generic name: reboxetine

Class: Antidepressant. Specifically a Norepinephrine-Selective Reuptake Inhibitor (NSRI)

1.  Other brand names & branded generic names1

  • Norebox
  • Vestra
  • reboxetine mesilate (British Commonwealth spelling)

2.  FDA Approved Uses of Edronax (reboxetine)

Reboxetine isn’t approved for anything in the US. We have Strattera (atomoxetine) instead, which is approved to treat ADD/ADHD in the US. In commie In un-American Outside of the US in many places you’ll now find Strattera (e.g. Australia, Canada, Ireland, New Zealand and the UK) you’ll find reboxetine approved to treat depression-spectrum disorders, usually major depressive disorder (MDD).

3.  Off-Label Uses of Edronax (reboxetine mesylate)

4.  Edronax (reboxetine) pros and cons

4.1  Pros

It’s NSRI, which means:

  • Low side effect profile
  • No discontinuation syndrome like SSRIs and SNRIs
  • It’s less likely to trigger mania in the bipolar than SSRIs

4.2  Cons

It’s an NSRI, which means:

  • While the side effect profile may be low, one or more of the common side effects are more likely to hang around than is the case with an SSRI, SNRI, or TCA.
  • You can’t legally buy it in the US, and it’s a pain in the ass to legally import it for your own use.
  • Even if you can buy it, Edronax comes in one dosage: 4mg. Take it or leave it.
  • If you’re bipolar and aren’t stable, even stable in being depressed the same way for months, it’ll destabilize you further.
  • And it might be difficult to tell if reboxetine did trigger a mania after all, as one side effect of NSRIs is short-term euphoria without any other symptoms of mania. Making reboxetine and Strattera true “happy pills,” for a little while.

5.  Edronax (reboxetine) Side Effects

5.1  Typical Side Effects

The usual for NSRIs - headache, dry mouth, urinary hesitance, constipation, insomnia/early awakening. The headache tends to go away and only reappears with a dosage increase for most people. The urinary hesitance, dry mouth, constipation and insomnia and/or early awakening can be your constant companions or strike at random throughout the time you take it.

5.2  Not So Common Side Effects of Edronax (reboxetine)

Increased heart rate or heart palpitations. Getting really sweaty. Chills. Like Strattera (atomoxetine) the PI sheets list, and guys have reported temporary and permanent (for as long as you take it) sexual side effects ranging from painful ejaculation to erectile dysfunction. Read about a couple cases of more unusual problems below…

5.3  Freaky Rare Side Effects of Edronax (reboxetine)

This is almost as good as, and obviously related to, Savella’s freaky rare side effect (which is currently The. Best. Freaky Rare Side Effect. Ever.):
Reboxetine induced erectile dysfunction and spontaneous ejaculation during defecation and micturition [urination]. I can’t wrap my head around the concept of simultaneously pissing and coming, but this is an extremely rare as well as freaky side effect, so all you guys into water sports may as well forget about trying to get some reboxetine. If reboxetine is going to mess with your party-time plumbing™, it will probably be more like this guy’s story.

6.  Interesting Stuff Your Doctor Probably Won’t Tell You about Edronax (reboxetine)

Women may respond to SSRIs better than NSRIs, so this may not necessarily be the best route for girls.

Stick to your AD-based treatment plan with buttons and magnets. 2.25″ $4 & 3.5″ $4.50 at Straitjacket T-shirts
Medicine Is The Best Medicine buttons at Straitjacket T-shirts
Medicine Is The Best Medicine buttons
Fuck Depression buttons at Straitjacket T-shirts
Fuck Depression buttons
Team OCD buttons at Straitjacket T-shirts
Team OCD buttons
I <3 Wellbutrin buttons at Straitjacket T-shirts
I <3 Wellbutrin buttons

7.  Reboxetine’s Dosage and How to Take Edronax (reboxetine)

The recommended initial dose is 4mg twice a day. After three weeks it may be increased to 10–12mg total, however you want to divide your 2.5 to 3 tablets. The optimal dosage is in the range of 8–12mg a day.
As usual we disagree, and suggest starting at 4mg a day, divided in half (the pills are made to be split), maybe even 2mg once a day. Then increase by 2mg a day after two-three weeks as required.

8.  How Long Edronax (reboxetine) Takes to Work

An average of two weeks in a range of 10 to 30 days.

9.  How to Stop Taking Edronax (reboxetine)

It’s an NSRI, so if you have the luxury to taper, by all means do so. Reduce the dosage by 4mg a day every 3 days. But if you need to stop immediately, that’s usually not much of a problem. If you do quit cold turkey expect rebound symptoms, which may include panic attacks and short-lived euphoric or dysphoric mania.

10.  Reboxetine’s Half-Life & Average Time to Clear Out of Your System

With a half-life of 12–13 hours, reboxetine is usually cleared in 3–4 days.

11.  Days to Reach a Steady State

Five days.

12.  Shelf Life

3 years.

13.  How Edronax (reboxetine) Works

Based upon the Communications Interference Hypothesis of psychiatric and neurological conditions, or brain cooties, reboxetine effectively raises the norepinephrine levels in your brain by letting your synapses soak in norepinephrine for longer than usual by slowing (inhibiting) the mechanism of norepinephrine transmission deeper into the neurons (reuptake).


I really wish I knew why drug companies didn’t make more norepinephrine-selective reuptake inhibitors (NSRIs). I know I’m not the only person to respond well to them. Let’s ask PubMed…

Reboxetine vs. Zoloft for MDD. Reboxetine was more effective. It may have sucked a little more, but it still worked better.

Reboxetine vs. Effexor They work equally well. Reboxetine is a little faster and, as above, sucks a little more. Although this study was far too brief to take into account having to stop taking either med.

OK, this one is super-specific, so I’m using the actual study title: Reboxetine versus fluvoxamine in the treatment of motor vehicle accident-related posttraumatic stress disorder: a double-blind, fixed-dosage, controlled trial.
Then again, it is an Israeli study, and a huge chunk of the population there has combat PTSD (which responds to meds and talk therapy differently) and similar forms, so I can understand the need for specificity. Reboxetine worked just as well but sucked more. Starting at 8mg a day.

Reboxetine vs. Celexa Celexa worked a little better and, except for sexual side effects, sucked less than reboxetine.

Along similar lines Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. Reboxetine and Prozac were equally effective, and Prozac sucked less, except for sexual side effects.

Somebody came up with the brilliant idea of treating depression-induced sexual dysfunction with Paxil. Not as some grasping at straws thing, but as a normal course of treatment. If you can get grant money for that then I really need to get better letters after my name. Reboxetine vs. Paxil for fixing sexual dysfunction & MDD. Seriously. Reboxetine wins. I imagine you’re shocked.

On the down side there is this meta-analysis: Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials, which basically says, “Reboxetine doesn’t do shit for depression. You’re better off with a placebo, or if you’re really depressed, take an SSRI.” The problem is, meta-analyses are like statistics, you can make them prove anything you want. What gets lost in the information overload are the people with niche depression spectrum conditions who don’t respond to serotonin-based treatments but do respond to norepinephrine-based treatments.

Reading all those studies makes it look as if Edronax isn’t worth exploring. Note what they all have in common: everyone started a 8mg a day. No wonder they were all hit with suck-ass side effects. At Crazymeds we’re all about start low, titrate slow, and no target dosage. However the overall responder rate is pretty small, and my best guess is somewhere that in the 10–15% range, 20% at the most, of people with a mood disorder need adjustment to norepinephrine alone, so SNRIs like Cymbalta (duloxetine) or the dopamine & norepinephrine reuptake inhibitor Wellbutrin (bupropion) would not be appropriate.

For some time the only NSRI available was either or both of Edronax (reboxetine) or viloxazine. Unless you have catalepsy, good luck with that viloxazine prescription. In Canada Strattera has gone off patent so, you can now get both generic atomoxetine and reboxetine in the Great White North. Both drugs are available as brand in the UK Ireland.

These will stick around longer than AD side effects. More ways to be stuck-up at Straitjacket T-shirts. All stickers only $5
Medicine Is The Best Medicine stickers at Straitjacket T-shirts
Medicine Is The Best Medicine stickers
Fuck Depression stickers at Straitjacket T-shirts
Fuck Depression stickers
PTSD Sucks! stickers at Straitjacket T-shirts
PTSD Sucks! stickers
Fuck Bipolar bumper stickers at Straitjacket T-shirts
Fuck Bipolar bumper stickers

15.  Edronax Ratings, Reviews, & Other Sites of Interest

Edronax Ratings & Reviews Page.

15.1  Rate Edronax

Give your overall impression of Edronax on a scale of 0 to 5. Detailed ratings and reviews are available on the Edronax Ratings & Reviews Page.

Get all critical about Edronax

4.5 stars Rating 4.1 out of 5 from 8 criticisms.
Vote Distribution: 0 – 0 – 0 – 1 – 5 – 2

15.2  Rate this article

If you’re still feeling judgmental as well as just mental2, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.

Get all judgmental about the Edronax (reboxetine) Synopsis

4 stars Rating 4.0 out of 5 from 4 value judgments.
Vote Distribution: 0 – 0 – 0 – 0 – 4 – 0

15.3  Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, check for drug-drug interactions

Edronax’s Full US Prescribing Information / PI Sheet

Australian Edronax PI
Irish Edronax SPC
Irish Edronax PIL
New Zealand Edronax CMI
New Zealand Edronax MDS Which looks a hell of a lot like a scanned photocopy of an Australian PI.
UK Edronax SPC
UK Edronax PIL’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.

15.4  Discussion board

If you have any questions not answered here, please see the Crazymeds Edronax discussion board.

Keep Crazymeds on the air.
Donate some spare electronic currency
you have floating around The Cloud
Display your mad pride.    
Tell your imaginary friends about Crazymeds.

16.  Bibliography

The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition by Stephen Stahl

All those PIs/SPCs listed above.

1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.

2 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!

If you have any questions not answered here, please see the Crazymeds Edronax discussion board. I welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why I write these damn things. I’m frustrated enough as it is. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds.

Last modified on Sunday, 23 March, 2014 at 14:07:59 by SomeMedCriticPage Author: JerodPooreDate created Wednesday, 20 July, 2011 at 18:01:40

Edronax by JerodPoore is copyright © 2011 JerodPoore

Edronax, and all other drug names on this page and use throughout the site, are a trademark of someone else. Look on the the PI sheet or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing.

Page design and explanatory material by Jerod Poore, copyright © 2004 - 2014. All rights reserved.
Keep up with Crazymeds and and/or my slow descent into irreparable madness boring life. Pick your preferred social media target(s):

Jerod Poore
Wear my StraitjacketBatshit Crazy Blog
Crazymeds | Promote Your Page Too
Crazymeds on Facebook
Play Dress-Up with your Imaginary FriendsCrazymeds: The Blog

Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.

All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
All brand names of the drugs listed in this site are the trademarks of the companies named on the PI/SPC sheet associated with the medication, sometimes on the pages about the drugs, even though those companies may have been acquired by other companies who may or may not be listed in this site by the time you read this. Or the rights to the drug were sold to another company. And any or all of the companies involved may have changed their names.
Crazymeds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore

1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?
[begin rant] I rent a dedicated server for Crazymeds. It’s sitting on a rack somewhere in Southern California along with a bunch of other servers that other people have rented. The hardware is identical, but no two machines have exactly the same operating systems. I don’t even need to see what is on any of the others to know this. If somebody got their server at the exact same time, with the exact same features as I did, I’m confident that there would be noticeable differences in some aspects of the operating systems. So what does this mean? For one thing it means that no two computers in the same office of a single company have the same operating system, and the techs can spend hours figuring out what the fuck the problem could be based on that alone. It also means that application software like IP board that runs the forum here has to have so many fucking user-configurable bells and whistles that even when I read the manual I can’t find every setting, or every location that every flag needs to be set in order for a feature to run the way I want it to run. And in the real world it means you can get an MBA not only with an emphasis on resource planning, but with an emphasis on using SAP - a piece of software so complex there are now college programs on how to use it. You might think, “But don’t people learn how to use Photoshop or Adobe Illustrator in college?” Sure, in order to create stuff. And in a way you’re creating stuff with SAP. But do you get a Bachelor of Fine Arts degree with an emphasis on Photoshop?
Back in the Big Iron Age the operating systems were proprietary, and every computer that took up an entire room with a raised floor and HVAC system, and had less storage and processing power than an iPhone, had the same operating system as every other one, give or take a release level. But when a company bought application software like SAP, they also got the source code, which was usually documented and written in a way to make it easy to modify the hell out of it. Why? Because accounting principles may be the same the world over, and tax laws the same across each country and state, but no two companies have the same format for their reports, invoices, purchase orders and so forth. Standards existed and were universally ignored. If something went wrong it went wrong the same way for everyone, and was easy to track down. People didn’t need to take a college course to learn how to use a piece of software.
I’m not against the open source concept entirely. Back then all the programmers read the same magazines, so we all had the same homebrew utilities. We even had a forerunner of QR Code to scan the longer source code. Software vendors and computer manufacturers sponsored conventions so we could, among other things, swap recipes for such add-ons and utilities. While those things would make our lives easier, they had nothing to do with critical functions of the operating system. Unless badly implemented they would rarely cause key application software to crash and burn. Whereas today, with open source everything, who the hell knows what could be responsible some part of a system failing. [/end rant]

Enable Crazymeds’ Financial Solvency!

Enable Crazymeds to keep spreading our knowledge. Donate some spare e-currency you have floating around The Cloud.

Improve Your Social Media Skills


Follow our Highly Irregular Updates and Paranoid Rants Other News


Show us teh like™

Square this Circle

Crazymeds for Twits

Sites That Probably Suck Less Than Crazymeds

Crazymeds Merchandise

Available at Straitjacket T-Shirts

Batshit Crazy shirts at Straitjacket T-Shirts

Clothes Hoist
T-Shirts, Hoodies & More $15-$43

Pile of Pills Mugs at Straitjacket T-Shirts

Get Mugged
11oz $13 & 15oz $14

Medicine is the Best Medicine Bumpersticker at Straitjacket T-Shirts

Stuck Up
All stickers $5

Mentally Interesting Button at Straitjacket T-Shirts

Button It!
2.25″ $4 & 3.5″ $4.50

Heart of Pills Earrings at Straitjacket T-Shirts

Dangly Bits
Earrings, Bracelets & More $15-$40

Pile Of Pills Gel Mousepad at Straitjacket T-Shirts

Yet more crap
$12 Mousepads to $85 Tablecloths

Burning Mind Books

Psychopharmacology tomes at Burning Mind Books

Books & Other Media for the Mentally Interesting

Replace my awful design choices with your own

Return to the Original Flavor