|US brand name: Edronax|
|Generic name: reboxetine|
side effects, dosage, how to take & discontinue, uses, pros & cons, and more
Table of Contents (hide)
- 1. Other brand names & branded generic names1
- 2. FDA Approved Uses of Edronax (reboxetine)
- 3. Off-Label Uses of Edronax (reboxetine mesylate)
- 4. Edronax (reboxetine) pros and cons
- 5. Edronax (reboxetine) Side Effects
- 6. Interesting Stuff Your Doctor Probably Won’t Tell You about Edronax (reboxetine)
- 7. Reboxetine’s Dosage and How to Take Edronax (reboxetine)
- 8. How Long Edronax (reboxetine) Takes to Work
- 9. How to Stop Taking Edronax (reboxetine)
- 10. Reboxetine’s Half-Life & Average Time to Clear Out of Your System
- 11. Days to Reach a Steady State
- 12. Shelf Life
- 13. How Edronax (reboxetine) Works
- 14. Comments
- 15. Edronax Ratings, Reviews, & Other Sites of Interest
- 16. References
Class: Antidepressant. Specifically a Norepinephrine-Selective Reuptake Inhibitor (NSRI)
1. Other brand names & branded generic names1
- reboxetine mesilate (British Commonwealth spelling)
Reboxetine isn’t approved for anything in the US. We have Strattera (atomoxetine) instead, which is approved to treat ADD/ADHD in the US.
In commie In un-American Outside of the US in many places you’ll now find Strattera (e.g. Australia, Canada, Ireland, New Zealand and the UK) you’ll find reboxetine approved to treat depression-spectrum disorders, usually major depressive disorder (MDD).
- Panic/Anxiety, especially anything having to do with social anxiety/phobia/avoidance
- Adult ADD/ADHD
- Panic disorder in general and SSRI-resistant panic disorder
- Seasonal Affective Disorder (SAD)
- As an add-on to SSRIs for treatment-resistant MDD
- As an add-on to treat schizophrenia
- Eating disorders (Also this tiny study on binge eating and A case report in Portuguese)
- Chronic pain with depression
- Amphetamine withdrawal syndrome
- Cocaine dependence
- LSD-induced Hallucinogen Persisting Perception Disorder with depressive features
It’s NSRI, which means:
- Low side effect profile
- No discontinuation syndrome like SSRIs and SNRIs
- It’s less likely to trigger mania in the bipolar than SSRIs
It’s an NSRI, which means:
- While the side effect profile may be low, one or more of the common side effects are more likely to hang around than is the case with an SSRI, SNRI, or TCA.
- You can’t legally buy it in the US, and it’s a pain in the ass to legally import it for your own use.
- Even if you can buy it, Edronax comes in one dosage: 4mg. Take it or leave it.
- If you’re bipolar and aren’t stable, even stable in being depressed the same way for months, it’ll destabilize you further.
- And it might be difficult to tell if reboxetine did trigger a mania after all, as one side effect of NSRIs is short-term euphoria without any other symptoms of mania. Making reboxetine and Strattera true “happy pills,” for a little while.
The usual for NSRIs - headache, dry mouth, urinary hesitance, constipation, insomnia/early awakening. The headache tends to go away and only reappears with a dosage increase for most people. The urinary hesitance, dry mouth, constipation and insomnia and/or early awakening can be your constant companions or strike at random throughout the time you take it.
Increased heart rate or heart palpitations. Getting really sweaty. Chills. Like Strattera (atomoxetine) the PI sheets list, and guys have reported temporary and permanent (for as long as you take it) sexual side effects ranging from painful ejaculation to erectile dysfunction. Read about a couple cases of more unusual problems below…
This is almost as good as, and obviously related to, Savella’s freaky rare side effect (which is currently The. Best. Freaky Rare Side Effect. Ever.):
Reboxetine induced erectile dysfunction and spontaneous ejaculation during defecation and micturition [urination]. I can’t wrap my head around the concept of simultaneously pissing and coming, but this is an extremely rare as well as freaky side effect, so all you guys into water sports may as well forget about trying to get some reboxetine. If reboxetine is going to mess with your party-time plumbing™, it will probably be more like this guy’s story.
Women may respond to SSRIs better than NSRIs, so this may not necessarily be the best route for girls.
The recommended initial dose is 4mg twice a day. After three weeks it may be increased to 10–12mg total, however you want to divide your 2.5 to 3 tablets. The optimal dosage is in the range of 8–12mg a day.
As usual we disagree, and suggest starting at 4mg a day, divided in half (the pills are made to be split), maybe even 2mg once a day. Then increase by 2mg a day after two-three weeks as required.
An average of two weeks in a range of 10 to 30 days.
It’s an NSRI, so if you have the luxury to taper, by all means do so. Reduce the dosage by 4mg a day every 3 days. But if you need to stop immediately, that’s usually not much of a problem. If you do quit cold turkey expect rebound symptoms, which may include panic attacks and short-lived euphoric or dysphoric mania.
With a half-life of 12–13 hours, reboxetine is usually cleared in 3–4 days.
Based upon the Communications Interference Hypothesis of psychiatric and neurological conditions, or brain cooties, reboxetine effectively raises the norepinephrine levels in your brain by letting your synapses soak in norepinephrine for longer than usual by slowing (inhibiting) the mechanism of norepinephrine transmission deeper into the neurons (reuptake).
I really wish I knew why drug companies didn’t make more norepinephrine-selective reuptake inhibitors (NSRIs). I know I’m not the only person to respond well to them. Let’s ask PubMed…
Reboxetine vs. Zoloft for MDD. Reboxetine was more effective. It may have sucked a little more, but it still worked better.
Reboxetine vs. Effexor They work equally well. Reboxetine is a little faster and, as above, sucks a little more. Although this study was far too brief to take into account having to stop taking either med.
OK, this one is super-specific, so I’m using the actual study title: Reboxetine versus fluvoxamine in the treatment of motor vehicle accident-related posttraumatic stress disorder: a double-blind, fixed-dosage, controlled trial.
Then again, it is an Israeli study, and a huge chunk of the population there has combat PTSD (which responds to meds and talk therapy differently) and similar forms, so I can understand the need for specificity. Reboxetine worked just as well but sucked more. Starting at 8mg a day.
Along similar lines Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. Reboxetine and Prozac were equally effective, and Prozac sucked less, except for sexual side effects.
Somebody came up with the brilliant idea of treating depression-induced sexual dysfunction with Paxil. Not as some grasping at straws thing, but as a normal course of treatment. If you can get grant money for that then I really need to get better letters after my name. Reboxetine vs. Paxil for fixing sexual dysfunction & MDD. Seriously. Reboxetine wins. I imagine you’re shocked.
On the down side there is this meta-analysis: Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials, which basically says, “Reboxetine doesn’t do shit for depression. You’re better off with a placebo, or if you’re really depressed, take an SSRI.” The problem is, meta-analyses are like statistics, you can make them prove anything you want. What gets lost in the information overload are the people with niche depression spectrum conditions who don’t respond to serotonin-based treatments but do respond to norepinephrine-based treatments.
Reading all those studies makes it look as if Edronax isn’t worth exploring. Note what they all have in common: everyone started a 8mg a day. No wonder they were all hit with suck-ass side effects. At Crazymeds we’re all about start low, titrate slow, and no target dosage. However the overall responder rate is pretty small, and my best guess is somewhere that in the 10–15% range, 20% at the most, of people with a mood disorder need adjustment to norepinephrine alone, so SNRIs like Cymbalta (duloxetine) or the dopamine & norepinephrine reuptake inhibitor Wellbutrin (bupropion) would not be appropriate.
For some time the only NSRI available was either or both of Edronax (reboxetine) or viloxazine. Unless you have catalepsy, good luck with that viloxazine prescription. In Canada Strattera has gone off patent so, you can now get both generic atomoxetine and reboxetine in the Great White North. Both drugs are available as brand in the UK Ireland.
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Rating 4.2 out of 5 from 29 criticisms.
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15.3 Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, check for drug-drug interactions
Australian Edronax PI
Irish Edronax SPC
Irish Edronax PIL
New Zealand Edronax CMI
New Zealand Edronax MDS Which looks a hell of a lot like a scanned photocopy of an Australian PI.
UK Edronax SPC
UK Edronax PIL
It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.
If you have any questions not answered here, please see the Crazymeds Edronax discussion board.
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The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition by Stephen Stahl
All those PIs/SPCs listed above.1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.
2 Thank you! I'll be here at least 72 hours. Be sure to tip your content provider. And don't try the veal, it's cruelicious!
If you have any questions not answered here, please see the Crazymeds Edronax discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)
|Last modified on Sunday, 23 March, 2014 at 14:07:59 by SomeMedCritic||Page Author Jerod Poore||Date created|
|“Edronax (reboxetine): a Review for the Educated Consumer.” by Jerod Poore is copyright © Jerod Poore||Published online 2011/07/20|
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|Plain text:||Poore, Jerod. “Edronax (reboxetine): a Review for the Educated Consumer.” Crazymeds (crazymeds.us). ().|
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.
* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.