plus assorted interesting stuff about Cymbalta (duloxetine) your doctor won’t tell you

> Cymbalta Pros and Cons


How to Take and Discontinue | Cymbalta Index | Side Effects
Return to the Cymbalta Page

Anyone who uses this page, or any other short list of pros and cons, as the only sources of information in deciding which med to take for their condition is a complete idiot and/or crazier than they or anyone else suspects. Although far less stupid and/or crazy than those who choose meds based only on side effects or the recommendations of random people on sites like ask.yahoo.com.

Cymbalta Pros

Works quickly with a fairly low side effect profile for an SNRI. Less likely to poop-out than an SSRI. Probably the best painkiller around as far as approved antidepressants are concerned (because Savella (milnacipran) is not approved in the US as an antidepressant).


Cymbalta Cons

It’s an SNRI, which means a discontinuation syndrome from hell if you want/need to stop taking it.

Doctors don’t have the time to tell you everything about a drug. Patient information leaflets leave out a lot. Even if the PI sheet covers everything the language is so dense and obtuse that the good stuff is often lost in information overload. Most meds have something interesting about them.1

Interesting Stuff Your Doctor Probably won’t Tell You about Cymbalta (duloxetine)

  • Cymbalta is more effective when taken in the morning than in the evening. This has nothing to do with meals, it all has to do with our circadian rhythms.
  • Smoking decreases Cymbalta’s bioavailability by about one-third in smokers. Eli Lilly doesn’t recommend any changes to how much you take or how fast to increase the dosage if you smoke, but don’t be surprised if you need to take more sooner than you thought.

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Most drugs are known for something. Whenever Viagra or Cialis are mentioned what do you think of first? How effective either one is for erectile dysfunction? The pros and cons of each? Viagra’s weird side effect of cyanopsia (where everything you see is tinted blue)? Or that a hard-on can last over four hours, and that if it does you’re supposed to call Dr. Buzzkill about it to see if you may need a surgical happy ending?2

Crazy meds are no different. Most of them are notorious for some reason. Lamictal is best known for “The Rash” (or “The Lamictal Rash”), but it’s also the best drug on the planet to treat Bipolar II. Topamax is also known as Dopamax and Stupamax, and here at Crazymeds we coined the term “supermodel drugs” to describe Topamax and Zonegran, because they can make you skinny and stupid. Yet Topamax is also a Godsend for a lot of people with migraines and/or various forms of epilepsy, and is the first thing a lot of neurologists will prescribe.

Drugs can sometimes have lesser-known traits and effects that make them unique, such as Keppra’s ability to stop mania immediately as if it were an antipsychotic as well as killing brain cancer. Some are good, some are bad, some are just weird. Some might be helpful for you to know about in order to make the best use a med, or to help it suck less. Others are meaningful only to pharmacology geeks.

What Cymbalta (duloxetine) is Best Known for

Relieving one symptom of depression most medications, and doctors, tend to ignore: physical pain.
With SNRIs - unlike SSRIs - you should not drink alcohol. While drinking when taking other SNRIs like Effexor or Pristiq will just make you miserable, mixing booze and Cymbalta can kill you.

Noted Traits & Effects


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Bibliography

Cymbalta’s Full US Prescribing Information

Tabibi A, Abdi H, Mahmoudnejad N. “Erectile function and dysfunction following low flow priapism: a comparison of distal and proximal shunts.” Urology Journal 2010;7:174–177.

Contains up-close and personal pictures of rather bloody thigh and penis surgery. Don’t say I didn’t warn you.

{{$$bigbiblio}}

How to Take and Discontinue | Cymbalta Index | Side Effects


1 Interesting to me at any rate.

2 Fun facts: The cause of that never-ending boner (priapism) is often a blood clot, which can work its way loose, make its way to your brain or heart, and kill you. So it's not so much about the inconvenience of a tent pole that can never be unpitched, it's about a potentially fatal side effect of ED drugs that they never say is POTENTIALLY FATAL in the TV ads. Viagra and Cialis are as likely to kill you as an antidepressant, but is Tom Cruise jumping up and down on a couch screaming about that? Maybe Scientology alone couldn't help him with that. As for the surgery that might be required, see Erectile function and dysfunction following low flow priapism: a comparison of distal and proximal shunts for the gory details, with pictures that will make you lose a few inches.


If you have any questions not answered here, please see the Crazymeds Cymbalta discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher crazymeds.us


Last modified on Sunday, 22 September, 2013 at 20:51:38 by JerodPoorePage Author Date created
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Cymbalta, and all other drug names on this page and used throughout the site, are a trademark of someone else.

will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.




Page design and explanatory material by Jerod Poore, copyright © 2004 - 2014. All rights reserved.
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Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
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Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
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1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas? I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

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