Although the sample sizes from the field (i.e. what I can find on teh interwebs) are a lot smaller, Latuda seems to be more effective for schizophrenia than bipolar disorder. But I get the impression that people with schizophrenia are just more willing to put up with side effects than the bipolar. I know from 14 years of reading support groups and related sites that the bipolar are often usually whiny babies when it comes to side effects, so I’m pretty sure it’s not a question of efficacy but who is willing to put up with what for how long.
The recommended starting dose of LATUDA is 40 mg once daily. Initial dose titration is not required. LATUDA has been shown to be effective in a dose range of 40 mg/day to 160 mg/day. The maximum recommended dose is 160 mg/day.
Given how freaking potent Latuda is, and that they make a 20mg tablet, starting with 20mg is something worth discussing with your doctor. It all depends on how crazy you are at the moment, or if you’re currently taking an antipsychotic and the plan is to switch you to Latuda.
You must take Latuda with food, at least 350 calories. Sunovion has now spelled out this requirement as clearly as Pfizer has with Geodon. If you don’t take your Latuda with food it’s the same as if you’re taking a little less than half of your dosage.
While it’s usually a toss-up as to if you should take some in the morning or at night, based on what little I’ve found out, start by taking it in the morning. Latuda might still put you to sleep, but the odds are in favor of it waking you up more than knocking you out.
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How to Stop Taking Latuda (discontinuation / withdrawal)
For a medication with such potent anti-dopamine action, Latuda had surprisingly little affect on prolactin, blood sugar, cholesterol, and triglycerides. For many people in the clinical trials and follow-up studies, Latuda actually lowered the amount of bad cholesterol and triglycerides.
As one of the few crazy meds with a pregnancy category of B Latuda is safer to take than than practically every other drug discussed on this site if you’re considering to get, or happen to become, pregnant.
No matter which neurological and/or psychiatric drug you take, you’ll probably get one or more of these side effects. These will usually be gone, or at least will diminish to the point where you barely notice it most of the time, within a week or two.
Drowsiness / fatigue - even when taking stimulants in some circumstances.
Insomnia, instead of or alternating with the drowsiness.
Assorted other minor GI complaints (constipation, diarrhea, etc.)
Generally feeling spacey / out of it
Which can all add up to the ever-helpful “flu-like symptoms” listed as an adverse event on the PI sheet of practically every medication on the planet used to treat almost any condition humans and other animals could have.3
All crazy meds can, and probably will affect your dreams as well. There is no way of telling if that will be good or bad, let alone if this side effect is permanent or temporary.
Any of the above side effects you see listed again below means they’re even more likely to happen and/or stick around longer and/or are worse than most other meds.
Typical Potential Side Effects
Movement disorders . Movement disorders galore. 20–40% of the people in the clinical trials had some form of movement disorder, mainly akathisia (severe, overwhelming restlessness) and the rate of side effects in clinical trials are almost always lower than real life.
Nausea and other GI problems are common, but that’s often the case with any made you really need to take with food. Putting you to sleep (somnolence) and making you feel tired throughout the day (lethargy, sedation) are also common, but Latuda’s an antipsychotic, so what can you expect? Since Latuda is used to treat depression insomnia and anxiety are popular side effects.
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Glossopharyngeal dystonia - which is a combination of slurred speech and barely being able to breathe. The only reason this guy had it is because his doctor and pharmacist were both incompetent and failed to notice the drug-drug interaction of Prozac and Latuda.
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Don’t worry about buying one. Windows shop and share the designs you’d like to buy. Do you have something better to do right now?
What You Really Need to be Careful About
Do not even look at Prozac (fluoxetine), Luvox (fluvoxamine), nefazodone, carbamazepine, grapefruit juice, pomegranate juice, anything containing grapefruit or pomegranate, or anything else that affects CYP3A4.
Latuda’s Half-Life & How Long Until It Clears Your System
Plasma half-life: 18 hours. Cleared in approximately 5 days.
Half-life is the average time it takes for you to process half of the drug’s active ingredient. If a drug has a half-life of around 24 hours and you take a dose of 100mg, you’ll have roughly the equivalent a 50mg dose after one day, a 25mg dose after two days, and so on. The rule of thumb is: multiply the half-life by five and you get how long it is for the dose you took to be cleared from your bloodstream4, so there’s nothing swimming around to attach itself to your brain and start doing stuff. That’s called “plasma clearance.” Complete clearance is a complex equation based on a lot of factors which may or may not: be published in the PI sheet, include personal data like your weight, or even completely figured out by corporate and independent researchers. It usually winds up being 2–5 days after plasma clearance no matter what5, but can take weeks. Sometimes a drug will clear from your brain and other organs before it clears from your blood.
Steady state is the flipside of half-life. This is when you can expect to get over side effects caused by fluctuating amounts of a medication in your bloodstream. Often, but not always the same amount of time as the plasma clearance above.
In English: Blocking excess brain juice at the bits of your brain responsible for both the positive symptoms (the dopaminereceptors) of schizophrenia, like delusions and hallucinations, and its negative symptoms and bipolar depression (the serotoninreceptors). The effect on
Latuda is a really potent D2antagonist. It’s also a really potent 5HT7antagonist, which explains why it knocks some people out when it doesn’t touch H1 histamine receptors. Like Saphris, Latuda doesn’t touch M1muscarinic receptors. Latuda is also a moderate partial 5HT1Aagonist like Geodon and Seroquel. Latuda’s effect on 5HT1A, 5HT2A and 5HT7 explain why it’s a pretty good antidepressant and helps with negative symptoms.
The activity of LATUDA is primarily due to the parent drug. LATUDA is metabolized into two active metabolites (ID-14283 and ID-14326) and two major non-active metabolites (ID-20219 and ID-20220).
The pharmacokinetics of LATUDA is dose-proportional within a total daily dose range of 20 mg to 160 mg. Steady-state concentrations of LATUDA are reached within 7 days of starting LATUDA.
Following administration of 40 mg of LATUDA, the mean (%CV) elimination half-life was 18 (7) hours.
Absorption and Distribution: LATUDA is absorbed and reaches peak serum concentrations in approximately 1–3 hours. It is estimated that 9–19% of an administered dose is absorbed. Following administration of 40 mg of LATUDA, the mean (%CV) apparent volume of distribution was 6173 (17.2) L. LATUDA is highly bound (~99%) to serum proteins.
In a food effect study, LATUDA mean Cmax and AUC were about 3-times and 2-times, respectively, when administered with food compared to the levels observed under fasting conditions. LATUDA exposure was not affected as meal size was increased from 350 to 1000 calories and was independent of meal fat content [see Dosage and Administration (2.2)].
In clinical studies, establishing the safety and efficacy of LATUDA, patients were instructed to take their daily dose with food [see Dosage and Administration (2.2)].
The active ingredient is usually the same as the generic name, but more often than not it’s a chemical salt of the substance identified as the generic. E.g. Fluoxetine is the generic for Prozac, but the active ingredient is fluoxetine hydrochloride (or HCl). It usually doesn’t make much of a difference outside of the more esoteric aspects of a drug’s pharmacology, but not always.
Don’t even think about drinking grapefruit juice , pomegranate juice , eating grapefruits juice , or pomegranates , or anything else discussed on our page about such things. That goes double for taking meds that inhibit or induce CYP3A4. So if your doctor prescribes you Latuda when you’re taking one or more of the following:
then you need a new doctor. Unless you didn’t tell your doctor about the St. John’s wort. In which case you’re a moron and have no one to blame but yourself if the Latuda doesn’t work. The same goes for your pharmacist if they have all of what you’re taking in their database. There are also a bunch of non-crazy meds involved, but that’s why God invented drug-drug interaction checkers.
It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on teh Faecesbooks.
Learn more about drug-everything interactions on our page of tips about taking crazy meds.
Name, Address, Serial Number (Generic and Overseas Availability)
Not including controlled/extended/sustained release suffixes (Efexor ER, Trevilor retard e.g.) or branded generics that are a hyphenate of the generic name and the drug company name (Apo-Citalopram e.g.).
Lurasidone is sold as Latuda all over the world (so far). It is currently available in:
An L and the dosage are stamped / carved / engraved / debossed on one side of the tablet.
For some reason in Europe and the UK they use freebase lurasidone, and not lurasidone HCl, as the active ingredient, so dosages are smaller. CommieMetric European tablets come in 18.5, 37, and 74 mg strengths.
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Latuda was approved by the FDA to treat schizophrenia 28 October 2010 and bipolar depression 28 June 2013.
I’ve got to give props to Sunovion for how well the official Latuda site is geared towards the schizophrenic community, with families & caregivers as an adjunct, but still out in the open. In the way people with all sorts of brain cooties are encouraged to have a support network who aren’t afraid to be associated with them. Like similar well-made sites (e.g. the Invega Sustenna site), the Latuda site treats the schizophrenic as adults, able to read at a high-school level, and capable of making their own decisions when it comes to medication.
Now that Latuda has been approved to treat bipolar depression, the schizophrenia part of the site has been relegated to a subdirectory, with a small link to it on the all about bipolar home page. That’s not surprising. There’s a shitload more money in bipolar than there is in schizophrenia.
Latuda’s side effect profile is really odd. For a drug that kicks practically everyone’s ass at D2 (only some of the older APs like fluphenazine and thiothixene are more potent), and has the highest rates for movement disorders I’ve seen in a PI sheet, yet has, based on the information available so far, surprisingly little affect on prolactin, blood sugar, cholesterol, and triglycerides. I’m trying to wrap my head around that one. Maybe its (literally) shitty pharmacokinetics causes all that D2 action to bypass the pancreas and liver. Maybe it manages to exert its action at the serotonin receptors there much better than other APs, compensating for the D2 antagonism. Maybe some of both. Maybe it’s something else entirely - like Stahl’s “x-receptor,” an as-yet-discovered receptor, or property of a known receptor, that affects metabolic functions.
On the subject of side effects, here’s a great bit of refreshing honesty from a drug company:
Too bad the adverse reactions the R&D guys at Dainippon Sumitomo focused on were EPS and other movement disorders. Ooops. No wonder only a third of the people in the study completed it. And Latuda was approved in the US before Japan, where it was developed. Hell, it still isn’t approved in Japan (or anywhere else in Asia) to treat schizophrenia.
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If you’re still feeling judgmental as well as just mental7, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.
Get all judgmental about the Latuda (lurasidone) Synopsis
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Equivalent to an FDA New Drug Approval (NDA), which is something you often need to file a Freedom of Information Act (FOIA) request to get (after a long-ass time) from the FDA. This contains all sorts of stuff drug companies don’t like the public seeing, like:
data from animal tests that involve “sacrificing” monkeys and dogs
reports of people who died during clinical trials, even though it’s really obvious their deaths had absolutely nothing to do with the drugs being tested
So I can actually understand why Big Pharma doesn’t want a bunch of shrill antipsychiatry dildos getting a hold of such things to take out of context.
As they’ll just make up that sort of shit anyway, so you may as well make everything available to show that reality, while unfortunate, is much less bad than what the Breggins and their Scientology suck-ups make up.
3 As well as being an indication of half of said conditions.
4 Based on Julien's calculations from A Primer of Drug Action, the half-life multiplied by five is the generally accepted estimate of how long it takes a single dose of any given drug to be eliminated from the blood stream/plasma of someone with a normal metabolism. That's also the rough estimate for steady state if they can't get, or won't provide a number for that.
5 For crazy meds. I have no idea what the average complete clearance is for other types of medications. For all I know there are drugs that utterly vanish from your system in under five passes, and others that won't let go of your squishy bits for years after you stop taking them.
6 Which is fucking hilarious, because Latuda is manufactured in Ireland for distribution to those commies the rest of Europe.
7 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!
If you have any questions not answered here, please see the Crazymeds Latuda discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.us)
Last modified on Saturday, 01 November, 2014 at 18:32:19 by JerodPoore
Latuda, and all other drug names on this page and used throughout the site, are a trademark of someone else. Latuda’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.
All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot. Know your sources! Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList, NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Crazymeds is optimized for ridiculously large screens and browsers that don’t block ads. I use Firefox and Chrome, running under Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!
‘Everything is true, nothing is permitted.’ - Jerod Poore
1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internetis a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion of anonymity. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.
* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.