Brand & Generic Names; Drug Classes
|US brand name: Latuda|
|Generic name: lurasidone|
|Primary drug class: Antipsychotics|
|Additional drug class(es): Second Generation Antipsychotic / Atypical Antipsychotic (SGA / AAP), MoodStabilizers, Antidepressants|
Approved & Off-Label Uses (Indications)
Latuda’s US FDA Approved Treatment(s)
- Bipolar Depression (officially: Depressive episodes associated with Bipolar I Disorder)
Uses Approved Overseas but not in the US
So far only Latuda’s approval in Canada is the same as that in the US.
- In Australia, Britain, the EU, and Switzerland Latuda is approved only to treat schizophrenia, but not bipolar.
- In Japan Latuda is approved to treat bipolar depression, and is still undergoing trials for schizophrenia. It’s also pending approval as maintenance therapy for bipolar 1.
- Not yet approved for schizophrenia in Japan is even more hilarious than not being approved at all in Ireland, as lurasidone was developed by Dainippon Sumitomo Pharma in freaking Osaka!
- And is manufactured in Ireland for distribution in Britain and the rest of the EU.
- Pending approval to treat schizophrenia in China and Taiwan.1, 2
Off-Label Uses of Latuda
- Bipolar 2 (seriously, that’s an off-label prescription)
- as a full-on Bipolar mood-stabilizer
- an add-on (adjunctive) to an antidepressant to treat depression
When & If Latuda Will Work
Latuda’s Usual Onset of Action (when it starts working)
Like most antipsychotics you should feel Latuda doing something positive within one or two days.
Likelihood of Working
Although the sample sizes from the field (i.e. what I can find on teh interwebs) are a lot smaller, Latuda seems to be more effective for schizophrenia than bipolar disorder. But I get the impression that people with schizophrenia are just more willing to put up with side effects than the bipolar. I know from 14 years of reading support groups and related sites that the bipolar are
often usually whiny babies when it comes to side effects, so I’m pretty sure it’s not a question of efficacy but who is willing to put up with what for how long.
Taking and Discontinuing
How to Take Latuda
The recommended starting dose of LATUDA is 40 mg once daily. Initial dose titration is not required. LATUDA has been shown to be effective in a dose range of 40 mg/day to 160 mg/day. The maximum recommended dose is 160 mg/day.
Given how freaking potent Latuda is, and that they make a 20mg tablet, starting with 20mg is something worth discussing with your doctor. It all depends on how crazy you are at the moment, or if you’re currently taking an antipsychotic and the plan is to switch you to Latuda.
You must take Latuda with food, at least 350 calories. Sunovion has now spelled out this requirement as clearly as Pfizer has with Geodon. If you don’t take your Latuda with food it’s the same as if you’re taking a little less than half of your dosage.
While it’s usually a toss-up as to if you should take some in the morning or at night, based on what little I’ve found out, start by taking it in the morning. Latuda might still put you to sleep, but the odds are in favor of it waking you up more than knocking you out.
How to Stop Taking Latuda (discontinuation / withdrawal)
Reduce your dosage by 20 to 40mg a day every five days to a week.