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as treatments for depression, anxiety & more

SSRIs - The World’s Most Popular Antidepressants

These are the serotonin-selective (or serotonin-specific)1 reuptake inhibitors approved in the US that we have articles on. I’ve included some of the more popular trade names used in other countries.




Brief history of SSRIs

The original SSRI, zimelidine, made its debut in March 1972. It was developed by Drs. Arvid Carlsson and Hans Corrodi, and is based upon the antihistamines brompheniramine (Dimetapp), chlorpheniramine (Chlor-Trimeton), and diphenhydramine (Benadryl).

Soon other SSRIs were under development. Lundbeck’s citalopram was being developed at about the same time, although it wasn’t approved until 1989. DU 23000 - the designation used prior to the assignment of the generic name fluvoxamine - was being tested for depression as far back as 1977. Solvay released fluvoxamine as Fevarin in Switzerland in 1984, although it wasn’t approved in the US until 1993. According to Wikipedia Upstene (indalpine) was marketed in France from 1982 to 1987. The story about why it was pulled and other details are different than what is in David Healy’s Let Them Eat Prozac, but at least that book confirms Upstene’s existence in France in the 1980s. Indalpine may still be available somewhere.2 Eli Lilly’s Prozac (fluoxetine) received approval from the US FDA in 1987 and the rest quickly followed.

Pages and Forum Topics Google Thinks are Related to This One

Classifications of Antidepressants | Antidepressant Topic Index | NSRIs
SSRIs All on One Page | SSRIs Page & SNRIs 2




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1 We prefer Dr. Preskorn's serotonin-selective reuptake inhibitor (as well as norepinephrine-selective and whatever_monoamine-selective) because:
1) It's grammatically correct. "Selective serotonin" is a clumsy way to describe how reuptake inhibitor is supposed work on a single neurotransmitter. Even if most of them fail at being all that selective.
2) It allows for unambiguous initialisms / acronyms. SNRI means Serotonin-Norepinephrine Reuptake Inhibitor and NSRI means Norepinephrine-Selective Reuptake Inhibitor. Otherwise SNRI could mean either Serotonin-Norepinephrine Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor.

2 Several China-based pharmaceutical manufacturers offer Indalpine for sale. E.g. Beijing JHYB Pharm. Tech. http://www.jhyb.com.cn/hc_en/C0515.htm


Serotonin-Selective Reuptake Inhibitor (SSRI) and Serotonin & Norepinephrine Reuptake Inhibitor (SNRI) Antidepressants by Jerod Poore is copyright © 2010 Jerod Poore

Last modified on Monday, 27 July, 2015 at 10:00:20 by JerodPoorePage Author: Jerod PooreDate created: 26 November 2010

All drug names are the trademarks of someone else. Look on the appropriate PI sheets or ask Google who the owners are. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of any trademarks may have changed without my noticing.



Page design and explanatory material by Jerod Poore, copyright © 2003 - 2015. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.

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