Norepinephrine-Selective Reuptake Inhibitors (NSRIs) discussed on this site include:
Depending on where you live you may have only one NSRI from which to choose. In the US that’s Strattera (atomoxetine). Elsewhere in the world it’s reboxetine - sold under the brand names Edronax, Vestra and Norebox. Once upon a time Strattera was available only in the US. No longer. Strattera (atomoxetine) is now available in Australia, Canada, Great Britain, Ireland, and New Zealand. Maybe more countries. The third NSRI, Catatrol (viloxazine), is still available after all. In the US it has the nebulous status as an orphan drug1 - a medication for a rare condition. In this case catalepsy. Good luck getting a prescription for it if you don’t freeze up stiffer than the audience plant at a cut-rate Vegas hypnotist act.
Strattera doesn’t have FDA approval to treat depression, but it looks and acts so much like reboxetine that it may as well be an antidepressant. I classify it as an antidepressant based entirely upon its chemical structure and mechanism of action (how it works in your brain). Officially Strattera (atomoxetine) is miscellaneous psychotherapeutic agent, because non-stimulant treatment for ADD/ADHD still blows the FDA’s mind.
If you like, or think you might like an NSRI, but they are not, or are no longer an option for you, the next best thing is a TCA, specifically Norpramin (desipramine). Like all TCAs desipramine is also an antihistamine, a serotonin reuptake inhibitor, and has anticholinergic and norepinephrine antagonistic properties. Of all the TCAs desipramine is about as close to an NSRI as you’re going to get, because it does doesn’t mess with anything else, overall, as other TCAs. Vivactil (protriptyline) is also a good substitute, but obscure and expensive. At 50mg a day the generic (the brand is long gone) costs over $300 a month when you have to pay full retail.
Medicine Is The Best Medicine
I <3 Wellbutrin
- Low side effect profile
- While the possible side effects are fewer, and generally suck less, than those associated with SSRIs, SNRIs, TCAs and MAOIs, you’re actually more likely to have the common side effects, and for those problems to stick around.
- No discontinuation syndrome like SSRIs and SNRIs
- But NSRIs are more likely to poop-out (tachyphylaxis) than SSRIs, and you don’t have much choice in the way of other meds to try if that happens.
- NSRIs are less likely to trigger mania in the bipolar than SSRIs.
- While NSRIs are less likely to trigger mania, they are also far less likely to work for depression. People who need only norepinephrine adjustments to help with depression make up a small minority of the mood disorder population. My best guess is somewhere in the 10–15% range.
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2 If you can call up to three months "short-term." Don't expect Strattera to be any good as a party drug. It doesn't work that way.
Norepinephrine-Selective Reuptake Inhibitor (NSRI) Antidepressants by Jerod Poore is copyright © 2010 Jerod Poore
|Last modified on Wednesday, 18 March, 2015 at 13:14:56 by JerodPoore||Page Author: Jerod Poore||Date created: 26 November 2010|
All drug names are the trademarks of someone else. Look on the appropriate PI sheets or ask Google who the owners are. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of any trademarks may have changed without my noticing.
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Almost all of the material on this site is by Jerod Poore and is copyright © 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, and 2015 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.
All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList,
NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
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‘Everything is true, nothing is permitted.’ - Jerod Poore
1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.
* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.