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SSRIs | AD Topic Index | SNRIs

Norepinephrine-Selective Reuptake Inhibitors (NSRIs) discussed on this site include:

Depending on where you live you may have only one NSRI from which to choose. In the US that’s Strattera (atomoxetine). Elsewhere in the world it’s reboxetine - sold under the brand names Edronax, Vestra and Norebox. Once upon a time Strattera was available only in the US. No longer. Strattera (atomoxetine) is now available in Australia, Canada, Great Britain, Ireland, and New Zealand. Maybe more countries. The third NSRI, Catatrol (viloxazine), is still available after all. In the US it has the nebulous status as an orphan drug1 - a medication for a rare condition. In this case catalepsy. Good luck getting a prescription for it if you don’t freeze up stiffer than the audience plant at a cut-rate Vegas hypnotist act.

Strattera doesn’t have FDA approval to treat depression, but it looks and acts so much like reboxetine that it may as well be an antidepressant. I classify it as an antidepressant based entirely upon its chemical structure and mechanism of action (how it works in your brain). Officially Strattera (atomoxetine) is miscellaneous psychotherapeutic agent, because non-stimulant treatment for ADD/ADHD still blows the FDA’s mind.

If you like, or think you might like an NSRI, but they are not, or are no longer an option for you, the next best thing is a TCA, specifically Norpramin (desipramine). Like all TCAs desipramine is also an antihistamine, a serotonin reuptake inhibitor, and has anticholinergic and norepinephrine antagonistic properties. Of all the TCAs desipramine is about as close to an NSRI as you’re going to get, because it does doesn’t mess with anything else, overall, as other TCAs. Vivactil (protriptyline) is also a good substitute, but obscure and expensive. At 50mg a day the generic (the brand is long gone) costs over $300 a month when you have to pay full retail.


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NSRIs (i.e. Strattera and reboxetine, I may or may not - odds on may not - cover viloxazine) have a few things in common:

  • Low side effect profile
  • While the possible side effects are fewer, and generally suck less, than those associated with SSRIs, SNRIs, TCAs and MAOIs, you’re actually more likely to have the common side effects, and for those problems to stick around.
  • No discontinuation syndrome like SSRIs and SNRIs
  • But NSRIs are more likely to poop-out (tachyphylaxis) than SSRIs, and you don’t have much choice in the way of other meds to try if that happens.
    • At least the poop-out effect may not be totally random. Based upon anecdotal evidence only it seems like taking too much too soon, a common event with Strattera, frequently leads to Strattera’s failing. Sometimes it will work again, sometimes it won’t.
  • NSRIs are less likely to trigger mania in the bipolar than SSRIs.
    • But if you’re bipolar and aren’t stable, NSRIs tend to destabilize you further.
    • And it might be difficult to tell if you’re manic in the first place when one side effect is a short-term2 euphoria.
  • While NSRIs are less likely to trigger mania, they are also far less likely to work for depression. People who need only norepinephrine adjustments to help with depression make up a small minority of the mood disorder population. My best guess is somewhere in the 10–15% range.

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SSRIs | AD Topic Index | SNRIs



1 The FDA's website has a shitload of data on how you fill out the paperwork required to manufacture drugs for rare diseases. I can't find a fucking thing on how you're supposed to legally import something that has orphan drug status, is used overseas to treat what it has orphan status for, but isn't sold here for anything else. Like Sabril (vigabatrin) and Banzel (rufinamide) were like until a couple years back.

2 If you can call up to three months "short-term." Don't expect Strattera to be any good as a party drug. It doesn't work that way.


Norepinephrine-Selective Reuptake Inhibitor (NSRI) Antidepressants by Jerod Poore is copyright © 2010 Jerod Poore

Last modified on Sunday, 16 March, 2014 at 15:49:39 by JerodPoorePage Author: Jerod PooreDate created: 26 November 2010

All drug names are the trademarks of someone else. Look on the appropriate PI sheets or ask Google who the owners are. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of any trademarks may have changed without my noticing.





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Almost all of the material on this site is by Jerod Poore and is copyright © 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained through our personal experience and the experiences family, friends, what people have reported on various reputable sites all over teh intergoogles, the medications’ product information / summary of product characteristic (PI/SPC) sheets, and from sources that are referenced throughout the site. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or patient information leaflet (PIL) that comes with your medications and never ever throw them away.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
All brand names of the drugs listed in this site are the trademarks of the companies named on the PI/SPC sheet associated with the medication, sometimes on the pages about the drugs, even though those companies may have been acquired by other companies who may or may not be listed in this site by the time you read this. Or the rights to the drug were sold to another company. And any or all of the companies involved may have changed their names.
Crazymeds is optimized for the browser you’re not using on the platform you wish you had. Between you and me, it all looks a lot cleaner using Safari or Chrome, although more than half of the visitors to this site use either Safari or Internet Explorer, so I’m doing my best to make things look nice for IE as well. I’m using Firefox and running Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore


1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?
[begin rant] I rent a dedicated server for Crazymeds. It’s sitting on a rack somewhere in Southern California along with a bunch of other servers that other people have rented. The hardware is identical, but no two machines have exactly the same operating systems. I don’t even need to see what is on any of the others to know this. If somebody got their server at the exact same time, with the exact same features as I did, I’m confident that there would be noticeable differences in some aspects of the operating systems. So what does this mean? For one thing it means that no two computers in the same office of a single company have the same operating system, and the techs can spend hours figuring out what the fuck the problem could be based on that alone. It also means that application software like IP board that runs the forum here has to have so many fucking user-configurable bells and whistles that even when I read the manual I can’t find every setting, or every location that every flag needs to be set in order for a feature to run the way I want it to run. And in the real world it means you can get an MBA not only with an emphasis on resource planning, but with an emphasis on using SAP - a piece of software so complex there are now college programs on how to use it. You might think, “But don’t people learn how to use Photoshop or Adobe Illustrator in college?” Sure, in order to create stuff. And in a way you’re creating stuff with SAP. But do you get a Bachelor of Fine Arts degree with an emphasis on Photoshop?
Back in the Big Iron Age the operating systems were proprietary, and every computer that took up an entire room with a raised floor and HVAC system, and had less storage and processing power than an iPhone, had the same operating system as every other one, give or take a release level. But when a company bought application software like SAP, they also got the source code, which was usually documented and written in a way to make it easy to modify the hell out of it. Why? Because accounting principles may be the same the world over, and tax laws the same across each country and state, but no two companies have the same format for their reports, invoices, purchase orders and so forth. Standards existed and were universally ignored. If something went wrong it went wrong the same way for everyone, and was easy to track down. People didn’t need to take a college course to learn how to use a piece of software.
I’m not against the open source concept entirely. Back then all the programmers read the same magazines, so we all had the same homebrew utilities. We even had a forerunner of QR Code to scan the longer source code. Software vendors and computer manufacturers sponsored conventions so we could, among other things, swap recipes for such add-ons and utilities. While those things would make our lives easier, they had nothing to do with critical functions of the operating system. Unless badly implemented they would rarely cause key application software to crash and burn. Whereas today, with open source everything, who the hell knows what could be responsible some part of a system failing. [/end rant]

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