Drugs approved by the US FDA - including some1 trade names used overseas - to treat major depressive disorder (MDD) (as well as DSM-III and DSM-II variants and other conditions in the depression spectrum). Not all drugs are available under their brand name, and some overseas trade names are obsolete; both are included here to assist anyone who knows only the now-obsolete brand/trade names. These are grouped by US trade name2.
- Emsam (selegiline transdermal system) / Emsam patch
- Khedezla (freebase desvenlafaxine)
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Drugs approved outside of the US, but not by the US FDA, to treat depression spectrum disorders:
- Aurorix (moclobemide)
- Manerix (moclobemide)
- Deanxit (flupentixol and melitracen)
- dosulepin / dothiepin
- Edronax (reboxetine)
- Ixel (milnacipran)
- pirlindole / pirasidol
- Stablon (tianeptine) - Available in the US as a supplement.
- tandospirone - AKA Japanese BuSpar
- thioridazine - Available in the US, but off-label prescribing is prohibited.
- Tolvan (mianserin)
- Valdoxan (agomelatine)
- Vivalan (viloxazine)
Drugs commonly prescribed off-label to treat depression
- Anafranil (clomimpramine) - Anafranil is a TCA, thus chemically classified as an antidepressant, but approved in the US to treat anxiety and not depression.
- BuSpar (buspirone) - Used off-label as an add-on to an AD, or as monotherapy.
- Lamictal (lamotrigine)
- Latuda (lurasidone)
- Lovaza (omega-3-acid ethyl esters)
- Luvox (fluvoxamine) - Luvox, an SSRI and thus chemically classified as an antidepressant, is approved in the US to treat OCD, but not depression.
- Provigil (modafinil)
- Ritalin (methylphenidate)
- Savella (milnacipran) - Savella, an SNRI and thus chemically classified as an antidepressant, is approved in the US to treat fibromyalgia, but not depression.
- Seroquel (quetiapine)
- Strattera (atomoxetine) - like Anafranil, Luvox, and Savella, Strattera is chemically an antidepressant. It just isn’t approved as one.
- Zyban (bupropion) - Bupropion isn’t approved in most countries as an antidepressant, only as an aid in smoking cessation. So it’s prescribed off-label for depression in those countries. While it shouldn’t be as much of an issue in the US today, it was often necessary for doctors to prescribe Zyban instead of Wellbutrin because some insurance plans wouldn’t cover psych meds.
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2 Again, because this is primarily an American site, and Google expects a hierarchy of brand name, generic name, alternate names and ingredient.
Alphabetical List of Antidepressants by Jerod Poore is copyright © 2010
Author: Jerod Poore. Date created: 26 November 2010 Last edited by: JerodPoore on: 2015–08–29
Page design and explanatory material by Jerod Poore, copyright © 2003 - 2015. All rights reserved. See the full copyright notice for full copyright details.
Don’t automatically believe everything you read on teh Intergoogles. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. For more details see the Crazymeds big-ass disclaimer.