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US Brand Names: Serenity, Life Link, NCI Advanced Research, Atrium Nutrition, maybe others


Other Brand Names: I'm sure there are more


Generic Name: lithium orotate


Other Forms: Symmetry Homeopathic Nasal Spray


FDA Approved Uses:  None whatsoever


Off-Label Uses:  Bipolar Disorder, Depression, PMS/PMDD,  Migraines.


Pros: Allegedly it has no side effects.  But that turns out to be a lie (see below).


Cons: No real documentation that it actually works.  Has side effects after all.  Is potentially harder on your kidneys and is more expensive than lithium carbonate.



Typical Side Effects: Muscle weakness, apathy, loss of appetite (from all of one human trial).



Not So Common Side Effects:

 These may or may not happen to you don't, so don't be surprised one way or the other.



Freaky Rare Side Effects:

 You aren't going to get these. I promise.



Interesting Stuff Your Doctor Probably Won't Tell You: If your doctor is willing to discuss this stuff with you at all that is.  The only clinical trial was done in Germany in 19731.  As with any dietary supplement sold in the United States, there is no guarantee that what is on the label is really what is in the bottle. 


Dosage: Regardless of the disorder, it's 1-3 120mg tablets a day, "or as directed by your health care professional. " 


Days to Reach a Steady State: Probably a week (see half-life), but there are far too many variables involved with lithium. 

When you're fully saturated with the medication and less prone to peaks and valleys of effects. You still might have peaks of effect after taking many meds, but with a lot of the meds you'll have fewer valleys after this point. In theory anyway.



How Long it Takes to Work: Probably never.



Half-Life & Average Time to Clear Out of Your System: According to one study lithium orotate has the same pharmacokinetics in rats as lithium carbonate does.  As that's all I have to go on, I'm presuming it's 24 hours, thus it’s out of your system in about five days.

If you've worked your way up to a particular dosage, it's usually best to spend this many days at the next lowest dosage before going down the next lowest dosage before that and so forth. This is the least sucky way to avoid problems when stopping any psychiatric medication. Presuming you have the option of slowly tapering off them.






Comments: You see this stuff advertised on every mental health site and every mental health search you look at.  The question always comes up, "It has no side effects, should I try it?"

Well, don't pin your hopes on that "no side effects" stuff so quickly.  If it were so good, why wasn't it used sooner, especially since Dr. Nieper's work was published over 30 years ago?

Because a subsequent study, again in rats not people, found that lithium orotate is even harder on your kidneys that lithium carbonate is!  Yow!  Lithium carbonate is hard enough on your plumbing, I'd hate to think what this crap would do to you.  The study concluded, "It seems inadvisable to use lithium orotate for the treatment of patients."  This was a follow-up to the study that showed you did get more lithium orotate in a rat's brain than you did with lithium carbonate.  But to get anywhere near a therapeutic dosage of lithium levels for bipolar disorder your kidneys would be in full revolt apparently.

Enough with the e-mail about the above studies.  Either rat studies aren't good enough at all, or rat studies are good.  You can't use one rat study to prove your point and dismiss another.

So the stuff has been studied.  It didn't pass the test of real science.  At least to be ethically tested on humans.  But, hey, if all y'all true believers want to volunteer for some double-blind studies, be my guest.  I think rat studies go only so far.  And not against placebo either.  I don't like placebo tests.  Lithium orotate vs lithium carbonate.  Or Depakote.  Or something else proven to work.  Put your mania where your mouth is.

But that's not what really convinced me it was crap.  What really convinced me it was crap was the information on the website of one of the distributors of a lithium orotate product.  They've toned it down a bit, but fortunately it lives on at The Silver Fleece Awards.  There used to be real gems up on the site, like:

originally discovered and patented by world-renowned Doctor, 
Scientist and Physicist, Hans A. Nieper, M.D.


Dr. Nieper's former patients include 
Princess Caroline of Monaco, John Wayne, Yul Brenner, Anthony Quinn, 
Natalie Woods (sic), Red Buttons, Fred McMurray, Russian Party 
leaders, the modern German King of Hanover, and many other worldwide 
dignitaries including members of the KGB before Communism fell...

Tell me, has your bullshit detector gone off yet?  Mine certainly did!  First the late doctor Nieper found time to be both a physicist and a medical doctor, then he treated a whole bunch of famous people who are all dead or otherwise in no position to talk about what the stuff was really like.

Yeah, I'm sure this crap works.

I could find just one open-label trial where lithium orotate was used as a psychiatric medication.  In a group of 105 alcoholics it was used to treat alcoholism along with the standard treatments and other mineral supplements.  The results:  only 42 could tolerate it after six months.  Of those, all of ten patients had no relapses after three years.  Granted, this is far from the med's ideal purpose, but it was the only human study I could find online.  And it shows that lithium orotate does have side effects when used at the recommended dosage, contrary to all the claims made about it, so they are listed above.




Manufacturers: Many in the US and Europe.


Sample US Cost: You can find out for yourself.  It varies widely.

As of 01/23/2004. Full retail for the uninsured. Go ahead and gloat, citizens of civilized countries and all of you with full medical coverage.


Sample Canadian Cost: The Canadians are too smart to allow this crap into their country.

As of 01/23/2004. In US dollars, for re-importation to the US. Does not include shipping charges or currency conversion charges you might incur on your credit card. Currency fluctuations will alter the price on a daily basis.


Remedy Find Rating for Bipolar Disorder


Check for Drug-Drug Interactions


No PI sheets, as it's officially just a supplement. 

Please see the section on how to read these sheets. Don't freak out about every potential side effect. Look at the odds of something having happened during the clinical trials.



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Take care, and keep taking your crazy meds!


If you still have unanswered questions about this or other medications, including which one is, or combination of meds are the best for you, your best bet is to ask on Crazy Meds Talk.  Better yet, if you want to let the world know how they worked out for you and want to help out others in their quest for the correct meds, join the party.
If you 
want to discuss your issues, I suggest checking out one of the various support groups online.  
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1 Agressologie. 1973; 14(6): 407-11. "The clinical applications of lithium orotate. A two years study." Nieper HA.


Created Friday, January 23, 2004

Last updated Friday, March 04, 2011


Copyright 2003 - 2006 Jerod Poore. All rights reserved.


Almost all of the material on this site is copyright 2002, 2003, 2004, 2005 and 2006 Jerod Poore. Except, of course, the PI sheets, those are the property of the drug companies who developed the drugs the sheets are about.  And any documents that are written by other people which may be posted to this site will remain the property of the original authors.  You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder.  That's usually me, so just ask first.  That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that's OK to just do.  Go for it!  Please.  As long as you include this copyright notice and the following disclaimer, I'm cool with it.

All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won't necessarily happen to you. Nobody on this site is a doctor, therapist, or a pharmacist. We don't portray them either here or on TV. Only doctors can diagnose and treat an illness. Some doctors tend to get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don't be a cyberchondriac, thinking you have every disease you see a website about, or that you'll get every side effect from every medication. Self-prescribing is just as dangerous.  All information on this site has been obtained through personal experience, the experiences of my friends, the experiences of people reported on online support groups, and from sources that are referenced throughout the site.  Know your sources!  As such the information presented here is not a substitute for real medical advice from your real doctor, just a compliment to it.  No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. All brand names of the drugs listed in this site are the trademarks of the companies listed after them in the pages about the drugs, even though those companies may or may not have been acquired by other companies who may or may not be listed in this site by the time you read this. Always read the PI sheet that comes with your medications and never ever throw them away.  If you didn't get a PI sheet, demand one.  Loudly.  Crazy Meds is not responsible for the content of sites we provide links to.  We like them, or they're paid advertisements, or they're something you should read to make an informed decision about a particular med.  Sometimes they're more than one of those things.  But what's on those sites is their business, not ours.  Very little information about visitors to this site is collected or saved. And from time to time I do look at search terms used to find it in an effort to make the information I present more relevant. Use only as directed. Void where prohibited.


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