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Lithium For Depression

#1 Guest_lolo132_*

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Posted 23 August 2007 - 11:29 AM

Wondering if anyone else hear has had luck with this. I'm currently on Effexor XR 225mg, Wellbutrin XL 150mg, and Ambien and Trazadone for sleep. I recently had my effexor decreased over the past couple of months from 375mg to the 225mg because of leg twitches/RLS. I'm leary about taking lithium but would like to feel better than I do now which wouldn't take much. I only seem to be able to get a month or two of feeling half way normal and then I go back to feeling really depressed and not sleeping.

any thoughts?

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Posted 28 August 2007 - 07:52 AM

i gotta agree with jook here, though ithium is mainly prescribed for mania it hits on depression too. actually lithium is really good for depression but you'd have to see if you really want to take it, the side effects are absolutely awful. way worse than antidepressants.

#3 User is offline   Pillboxfox 

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Posted 29 August 2007 - 02:05 PM

I've been taking Lithium for a while and have virtually no side effects either besides urinating more frequently and a really mild left hand tremor. I can live with that. Take 600mg/day and my level hangs at around 0.7. This med helped me a lot with both hypomania and depression. It seems there are no in-betweens with Lithium. Some people just love it and have no side effects, others hate it and get tons of side effects...

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Diagnosis: Bipolar type 2 disorder and substance abuse disorder (working hard on staying clean)
Daily med combo: Lithium 600mg + Remeron 30mg + Zyprexa 5mg (all taken at bedtime)
Lithium level: 0.5
PRN meds: Librium 10mg capsules, Haldol 2mg tabs
Emergency/crisis meds: Xanax 0.5mg tabs, Prolixin (fluphenazine) long-acting injection
Previously tried: Seroquel, Risperdal, Nozinan (levopromazine), Depakote, Lamictal, Effexor, Serzone, Trazodone, Celexa, Wellbutrin, Klonopin, Ativan, Restoril, Serax, Valium
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#4 User is offline   firedancer 

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Posted 30 August 2007 - 03:58 PM

discussed this very issue with pdoc yesterday since i am discontinuing lamictal (which has done wonders for my depression) and trying keppra for the migrianes and seizures. my concern was that i was going to spiral down into uncontrollable depression again. but we are increasing my lithium because pdoc says that it may very well work for that issue (it is already working miracles for the hypomania). so i'm keeping my fingers crossed.
Please be nice to me, I'm a blood donor (conquering my fear of needles one pint at a time).

Dx: BPII (and everything that comes along with it), Intractable Migraines (that means 3-5/week), Social & General Anxiety, Idiopathic Seizures 7/07

Current Rx: Seroquel, Lamictal, Zanaflex

Past Rx: Prozac, Paxil/CR, Lexapro, Cymbalta, Ambien CR, Wellbutrin XL, Effexor/XR, Depakote/ER, Keppra, Topamax, Neurontin, Zonegran, Xanax, Trazadone, Klonopin, Seroquel, Zyprexa, Lyrica, Trileptal, Ablify, Geodon, Ambien, Lunesta, Skelaxin, Doxepin, Flexiril, Verapamil, Lithium Carb, amitiptylin, triptans (can't take 'em), pain meds

be yourself because the people that mind don't matter and the people that matter don't mind - dr. seuss
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#5 User is offline   Rayjean 

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Posted 02 September 2007 - 04:17 PM

Lithium worked wonderfully for my depression for well over 20 years. Had to go off of it recently and when I went back on, it worked but not quite as well and I needed to take more of it to get a good effect.
It has helped my daughters depression beautifully.
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#6 User is offline   BuyPolar 

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Posted 05 September 2007 - 04:35 PM

lolo,

I misunderstood my pdoc, and thought I could taper off of lithium (@900mg/day) when starting a new medicine. I had the worse depression I ever experienced (lots and lots and lots of SI). And I was on Lamictal 100mg and Lexapro 10mg. Resuming the lithium brought me to around a 4 out of 10 moodwise, and now we're tweaking.

So to summarize, yes, lithium absolutely works for depression. It is said it augments antidepressants, but I really suspect in my case it is at the core of my maintenance.

The only side effect I experience is thirst (and the ensuing trip to the restroom).

This post has been edited by BuyPolar: 05 September 2007 - 04:38 PM

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#7 User is offline   Cyeic 

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Posted 05 September 2007 - 04:51 PM

View Postjook, on Fri 24 August 2007 0:41:16 GMT +0000, said:

There are a multitude of studies that show the reduction in suicides in mentally ill lithium users.


Indeed.

Lithium treatment reduces suicide risk in recurrent major depressive disorder.

Quote

This is the first meta-analysis suggesting antisuicidal effects of lithium in recurrent MDD, similar in magnitude to that found in bipolar disorders.

Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review.

Quote

Risks of completed and attempted suicide were consistently lower, by approximately 80%, during treatment of bipolar and other major affective disorder patients with lithium for an average of 18 months. These benefits were sustained in randomized as well as open clinical trials.

Useful Journals:

Blackwell Synergy
Science Direct

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#8 User is offline   dalka 

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Posted 22 September 2007 - 06:14 PM

I'm primarily depressive (even for bpII), and, for me at least, it kicks depression's ass! It makes all emotions feel farther away or quieter, so it profoundly affects me, no matter what the mood, even if I'm comparatively stable. It utterly stomps intrusive thoughts.
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#9 User is offline   firedancer 

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Posted 03 October 2007 - 03:38 PM

so far lithium has really worked for me. pdoc switched me to eskalith cr @ 900mg/day (450mg2x) and today is my first day on that. has some tummy trouble most of the day, but it was similar to when i started lithium carb, so i'm sure it will pass.

anyone else on this form (eskalith cr)?
Please be nice to me, I'm a blood donor (conquering my fear of needles one pint at a time).

Dx: BPII (and everything that comes along with it), Intractable Migraines (that means 3-5/week), Social & General Anxiety, Idiopathic Seizures 7/07

Current Rx: Seroquel, Lamictal, Zanaflex

Past Rx: Prozac, Paxil/CR, Lexapro, Cymbalta, Ambien CR, Wellbutrin XL, Effexor/XR, Depakote/ER, Keppra, Topamax, Neurontin, Zonegran, Xanax, Trazadone, Klonopin, Seroquel, Zyprexa, Lyrica, Trileptal, Ablify, Geodon, Ambien, Lunesta, Skelaxin, Doxepin, Flexiril, Verapamil, Lithium Carb, amitiptylin, triptans (can't take 'em), pain meds

be yourself because the people that mind don't matter and the people that matter don't mind - dr. seuss
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#10 User is offline   romancandle 

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Posted 03 October 2007 - 05:31 PM

View Postjook, on Wed 3 October 2007 20:06:43 GMT +0000, said:

Lithobid caused less stomach upset than the other two so I stuck with it.


You know, I always wondered the differences between the different forms of lithium [My doc, when prescribing, was kind of thinking out loud as to which I should go on]. Do you know other people who experience less nausea on Lithobid?

As far as my experiences go, I love my Lithium [Lithium Carbonate], despite the side effects. It has helped with depression, just gotta have the right dose. Nice to read this articles about the lessened suicide risk, always wondered. My side effects thus far...I've had the tremors in my hands [left more than my right] and nausea. I'm finding ways of coping with the nausea though.
Cocktail: Lamictal - 200mg, Neurontin - 600mg, Lithium - 600mg, Cymbalta - 60mg, Deplin - 7.5mg, Synthroid - 25mcg, Promethezine - PRN, Klonopin - PRN, Seasonique

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#11 User is offline   firedancer 

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Posted 07 October 2007 - 12:28 PM

i loved my lithium carb too but pdoc wanted to up the dose. and since i have hard time remembering to take my meds (my cell phone has an alarm thank goodness that reminds me) and i'm taking all my meds twice day, adding a third dose of the lithium i guess concerned him. so hence the switch to eskalith cr at 900mg (2xday) instead of lithium carb 900mg (3xday).

thank goodness i have a pdoc that understands me.

the only side effects so far is still the tummy trouble, but i'm sure that will pass.
Please be nice to me, I'm a blood donor (conquering my fear of needles one pint at a time).

Dx: BPII (and everything that comes along with it), Intractable Migraines (that means 3-5/week), Social & General Anxiety, Idiopathic Seizures 7/07

Current Rx: Seroquel, Lamictal, Zanaflex

Past Rx: Prozac, Paxil/CR, Lexapro, Cymbalta, Ambien CR, Wellbutrin XL, Effexor/XR, Depakote/ER, Keppra, Topamax, Neurontin, Zonegran, Xanax, Trazadone, Klonopin, Seroquel, Zyprexa, Lyrica, Trileptal, Ablify, Geodon, Ambien, Lunesta, Skelaxin, Doxepin, Flexiril, Verapamil, Lithium Carb, amitiptylin, triptans (can't take 'em), pain meds

be yourself because the people that mind don't matter and the people that matter don't mind - dr. seuss
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#12 User is offline   Stacia 

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Posted 07 October 2007 - 06:01 PM

View Postfiredancer, on Sun 7 October 2007 12:28:41 GMT +0000, said:

i loved my lithium carb too but pdoc wanted to up the dose. and since i have hard time remembering to take my meds (my cell phone has an alarm thank goodness that reminds me) and i'm taking all my meds twice day, adding a third dose of the lithium i guess concerned him. so hence the switch to eskalith cr at 900mg (2xday) instead of lithium carb 900mg (3xday).

thank goodness i have a pdoc that understands me.

the only side effects so far is still the tummy trouble, but i'm sure that will pass.

I'm on Lith Carb ER and take it all at night. It's not on Target's $4 list, but my insurance covers it. Maybe ask your doc about it.

This post has been edited by Anastacia: 07 October 2007 - 06:02 PM

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#13 User is offline   firedancer 

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Posted 10 October 2007 - 06:55 AM

View PostAnastacia, on Sun 7 October 2007 21:01:12 GMT +0000, said:

View Postfiredancer, on Sun 7 October 2007 12:28:41 GMT +0000, said:

i loved my lithium carb too but pdoc wanted to up the dose. and since i have hard time remembering to take my meds (my cell phone has an alarm thank goodness that reminds me) and i'm taking all my meds twice day, adding a third dose of the lithium i guess concerned him. so hence the switch to eskalith cr at 900mg (2xday) instead of lithium carb 900mg (3xday).

thank goodness i have a pdoc that understands me.

the only side effects so far is still the tummy trouble, but i'm sure that will pass.

I'm on Lith Carb ER and take it all at night. It's not on Target's $4 list, but my insurance covers it. Maybe ask your doc about it.



that is what sucked about switching from lithium carb, it being a $4 generic and the eskalith cr is around $30ish. but i did switch from ambien cr to regular ambien and with the card i got off the internet it only cost me $11 (from $85), so i wasn't so upset with the eskalith cr increase. but i will mention the lith carb er, next time i'm at target i'll ask how much it would cost.
Please be nice to me, I'm a blood donor (conquering my fear of needles one pint at a time).

Dx: BPII (and everything that comes along with it), Intractable Migraines (that means 3-5/week), Social & General Anxiety, Idiopathic Seizures 7/07

Current Rx: Seroquel, Lamictal, Zanaflex

Past Rx: Prozac, Paxil/CR, Lexapro, Cymbalta, Ambien CR, Wellbutrin XL, Effexor/XR, Depakote/ER, Keppra, Topamax, Neurontin, Zonegran, Xanax, Trazadone, Klonopin, Seroquel, Zyprexa, Lyrica, Trileptal, Ablify, Geodon, Ambien, Lunesta, Skelaxin, Doxepin, Flexiril, Verapamil, Lithium Carb, amitiptylin, triptans (can't take 'em), pain meds

be yourself because the people that mind don't matter and the people that matter don't mind - dr. seuss
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#14 User is offline   martasi2 

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Posted 10 October 2007 - 09:31 AM

Ambien is now out in generic Zolpidem, if you can take the generic. It might save some money.

I want to put in a plug for liquid Lithium Citrate. It is much easier on the GI system but does require using a measure of some sort. It can be dosed to just about any level you want, whenever you want, and because it is a "citrate" and not a "carbonate" it tends to cause less GI symptoms.
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Posted 11 October 2007 - 06:54 PM

View Postmartasi2, on Wed 10 October 2007 12:31:40 GMT +0000, said:

Ambien is now out in generic Zolpidem, if you can take the generic. It might save some money.

I want to put in a plug for liquid Lithium Citrate. It is much easier on the GI system but does require using a measure of some sort. It can be dosed to just about any level you want, whenever you want, and because it is a "citrate" and not a "carbonate" it tends to cause less GI symptoms.


i asked my pdoc about trying regular ambien again (the first time i tried it, it didn't work) but with the cocktail i take at night, i wondered if it would. so he wrote out a script for 30 and i'm on almost a week and it seems to be doing good. the generic was still expensive but i got this card online (UNA Rx card) for free and it went from being in the $80s for 30 pills to almost $12. so it saved me a bundle on that med.
Please be nice to me, I'm a blood donor (conquering my fear of needles one pint at a time).

Dx: BPII (and everything that comes along with it), Intractable Migraines (that means 3-5/week), Social & General Anxiety, Idiopathic Seizures 7/07

Current Rx: Seroquel, Lamictal, Zanaflex

Past Rx: Prozac, Paxil/CR, Lexapro, Cymbalta, Ambien CR, Wellbutrin XL, Effexor/XR, Depakote/ER, Keppra, Topamax, Neurontin, Zonegran, Xanax, Trazadone, Klonopin, Seroquel, Zyprexa, Lyrica, Trileptal, Ablify, Geodon, Ambien, Lunesta, Skelaxin, Doxepin, Flexiril, Verapamil, Lithium Carb, amitiptylin, triptans (can't take 'em), pain meds

be yourself because the people that mind don't matter and the people that matter don't mind - dr. seuss
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#16 Guest_lolo132_*

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Posted 08 April 2008 - 02:58 PM

I know I originally posted this about 8 months ago. I just started the Lithium at 600mg a day. It's been almost a week. I don't see any difference yet. Any improvement over how I feel now would be good. Just when I think I couldn't be worse it always seems to happen.

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Posted 22 May 2008 - 03:01 PM

It's been a long time since I've been on here, about three years. Back then my docs were still trying to figure out why I was so triggered by stuff, they figured it out in November.
That being said, I've been on Lithium since then. My dosage has gone up and down depending on what's happened in my environment. Had a horrible weekend in Seattle and I was incredibly depressed, so I got taken up to 1200 mg's for two weeks until I stabilized. Now that spring has finally hit the N.W., I'm not depressed or as low as my baseline is in the winter, so I'm going down to 300 mg's. But, I am also on 200 mg's of Lamictal to stabilize any mania that may rear it's ugly head in the summer (my bipolar usually follows the seasons).
I am an atypical patient when it comes to my meds, according to my pdoc. Most people take Lithium for mania and Lamictal for mania and depression. I'm quite the opposite, Lamictal doesn't touch my depression and quells the mania and Lithium brings me up from the deep depressive episodes that I have.
It's a constant vigilance that I personally have to keep with my meds. If I'm not feeling like myself, it's 9 times out of 10 my meds and something needs tweaking. Luckily, I have an incredibly responsive and available pdoc that answers pages at 10 o'clock on a Saturday night.
When I got to my therapeutic level (which is different for anyone), .4, I felt great and the depression was gone. Two weeks ago, however, I dove into a deep depression and it was from taking too much Lithium. Since I've slowly cut back, I'm feeling fine again. As it has been stated, everyone is different but it is important to keep track of your daily if not hourly moods. Especially so if you are a female. Your hormones can really effect how your medication works for you.
Hope that helps.

#18 User is offline   BlueMoon 

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Posted 24 May 2008 - 12:34 PM

View Postjook, on Sat 24 May 2008 7:00:04 GMT +0000, said:

Lithium+Lamictal is the best combination for bipolar disorder.

They compliment each other and act a little differently when combined then they do alone.
My moods were all over the map w/ Lamictal monotherapy.
Li staves off the worst symptoms but it isn't a cure-all for dysthymia or agitation.
The best I ever felt was when I was on this combo, that is until Lamictal made me rashy and I had to stop.
Then I had one of the worst manic crashes I've ever had because my Li serum level was too low.

Which goes to show- you can cut the Li dose down when you add Lamictal and curb Li side effects (tremors, weight gain) and still see some great results.
Since Lamictal is (almost) side effect free, it's a good, safe and painless combo.

Wish I could take it-

jook


Hey Jook! haven't posted in a while. I have a Li/Lamictal question for you. We finally found a pdoc who has 2 brain cells to rub together who looked at 3 years worth of records and said my kid is definitively BP (she had a major manic episode in December when her then pdoc tried to switch her from Abilify to Geodon.) Anyway, she started Li in Feb and then was titrated off abilify. As she has gone up on the Li, currently 300mg bid, she has become activated in the evening. So, is it the Li or the combo with Lamictal 200mg that is winding her up? I agree about moods still being all over the map with Lamictal monotherapy, it was the same thing here. Honestly, she has been on Lamictal for over a year now, and while it did help a little with her depression, the Li has been amazing for her. I would far rather try dialing back the Lamictal first. Thoughts please.

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Posted 22 June 2008 - 07:47 PM

View Postjook, on Sat 24 May 2008 4:00:04 GMT +0000, said:

Lithium+Lamictal is the best combination for bipolar disorder.

They compliment each other and act a little differently when combined then they do alone.
My moods were all over the map w/ Lamictal monotherapy.
Li staves off the worst symptoms but it isn't a cure-all for dysthymia or agitation.
The best I ever felt was when I was on this combo, that is until Lamictal made me rashy and I had to stop.
Then I had one of the worst manic crashes I've ever had because my Li serum level was too low.

Which goes to show- you can cut the Li dose down when you add Lamictal and curb Li side effects (tremors, weight gain) and still see some great results.
Since Lamictal is (almost) side effect free, it's a good, safe and painless combo.

Wish I could take it-

jook


I know this is an old thread, but this is precisely the question I was going to ask. I recently have had some problems with my meds and got a second opinion. I had been on monotherapy Lamictal (200mg) which went haywire after I started birth control. Birth control finished and decided to get off the Tegretol prescribed in the meantime.

I took Lithium last summer at about 900mg and was sick as a dog. I would feel like vomiting riding in an elevator (and I worked on the 52nd floor). There was the weight gain, bloat, and smell of alcohol making me want to die - but the nausea was the kicker. Blood level was at .7. Problem was, my mood was really good on this drug and I hated to give it up.

I love the Lamictal on its own too, but unfortunately I'm having too many breakthrough depressive episodes. The Pdoc I went to see suggested I try the same level of Lamictal with a baby's dose of Lithium. I was wondering what dose you started on to help avoid the side effects, and whether it affected your ability to concentrate (ie: if you turned into a zombie).

Thanks!

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Posted 28 June 2008 - 06:24 PM

Hi Jook,

Hope all is well in your little corner of the world. As a follow up, pdoc dialled back dd's Lamictal to 150 from 200, and things have been steadily improving, with a couple minor hiccups. I think the plan is to cut the Lamictal back to 100 and try to go up another 150 or 300 on Li. I am so kicking myself for not getting her on the Li sooner. But hindsight being what it is.......................................

Blue Moon
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