Is Ambien A Smooth Muscle Relaxer?
Posted 09 June 2008 - 08:08 PM
Current: Wellbutrin XL 300mg, Lamictal 100mg, zolpidem ~3.3mg, fish oil 2000mg, multi vitamin, lorazepam .5mg prn
Posted 10 June 2008 - 10:29 AM
Dx: Asperger's + Bipolar 1: Mixed Episode
Rx: Topamax 200mg + Valium 15mg + Zyprexa Zydis 5mg + Artane 6mg + Lunesta 3mg
Posted 10 June 2008 - 10:52 AM
--Poet Robert Lowell, to publisher Bob Giroux, about lithium
Posted 10 June 2008 - 12:23 PM
Then again. This is Ambien, it wakes up coma patients and makes sleeping Australians have sex with strangers. In other words, it's done stranger things.
Posted 10 June 2008 - 11:28 PM
There's your answer. At 3.3mg it's not going to be doing much in the way of muscle relaxation.
As an anticonvulsant and muscle relaxant, the beneficial effects start to emerge at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Such drastically increased doses are more inclined to induce one or more negative side effects, including hallucinations and/or amnesia.
Posted 13 June 2008 - 11:26 AM
Zolpidem (Ambien) is a nonbenzodiazepine that was marketed in 1993 for the short-term treatment of insomnia. Although structurally unrelated to the benzodiazepines, zolpidem acts similarly, binding to a specific subtype (type 1) of the GABA A receptor. It displays most of the actions of all the other benzodiazepine agonists: it is primarily a sedative rather than an anxiolytic, and its sedative actions overwhelm any anxiolytic effects.
At doses of 5 to 10 milligrams, zolpidem produces sedation and promotes a physiological pattern of sleep in the absence of anxiolytic, anticonvulsant, or muscle relaxant effects. Memory is adversely affected as it is by benzodiazepines.
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