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Is Ambien A Smooth Muscle Relaxer?


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#1 nettles

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Posted 09 June 2008 - 08:08 PM

Could Ambien be implicated in nighttime reflux? Maybe nightly Ambien is telling the lower esophageal sphinter to relax?
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#2 netsavy006

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Posted 10 June 2008 - 10:29 AM

I've not heard of Ambien being a smooth muscle relaxant.
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#3 sorrel

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Posted 10 June 2008 - 10:52 AM

Yes: like the benzodiazepines, to which it is closely related, Ambien does act as a smooth muscle relaxant. Here is an example of its effect on uterine muscles, but it can act on any smooth muscles.
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#4 Serpens

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Posted 10 June 2008 - 12:23 PM

Agreed. As a benzo relative, it could relax all sorts of strange muscles. I wouldn't think it would without something else granted on, though from your other thread I'd say all bets are off with your GI tract. My instinct is to look elsewhere for the problem.

Then again. This is Ambien, it wakes up coma patients and makes sleeping Australians have sex with strangers. In other words, it's done stranger things.
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#5 The Lightning Stalker

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Posted 10 June 2008 - 11:28 PM

As an anticonvulsant and muscle relaxant, the beneficial effects start to emerge at 10 and 20 times the dose required for sedation, respectively.[5] For that reason, it has never been approved for either muscle relaxation or seizure prevention. Such drastically increased doses are more inclined to induce one or more negative side effects, including hallucinations and/or amnesia.

There's your answer. At 3.3mg it's not going to be doing much in the way of muscle relaxation.
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#6 dymphna

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Posted 13 June 2008 - 11:26 AM

To quote my favorite guy (Robert Julian, A Primer of Drug Action):

Zolpidem (Ambien) is a nonbenzodiazepine that was marketed in 1993 for the short-term treatment of insomnia. Although structurally unrelated to the benzodiazepines, zolpidem acts similarly, binding to a specific subtype (type 1) of the GABA A receptor. It displays most of the actions of all the other benzodiazepine agonists: it is primarily a sedative rather than an anxiolytic, and its sedative actions overwhelm any anxiolytic effects.

[...]

At doses of 5 to 10 milligrams, zolpidem produces sedation and promotes a physiological pattern of sleep in the absence of anxiolytic, anticonvulsant, or muscle relaxant effects. Memory is adversely affected as it is by benzodiazepines.



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