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Sam-e


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#31 therapeuticbrigg84

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Posted 02 March 2009 - 12:56 PM

does sam-e kick in right away? or does it hav a delayed effect, cuz i took it one day and the following day i was in a great mood

dx: schizotypal personality disorder, dystonic neck and back pain, GERD. a bit of TD, akathisia, dysmorphic thoughts, affect is questionable

seroquel and inderal 60mg made me fatigued/ depressed. may hafta try lopressor or bisoprolol

inderal interacts with ssris and anti-psychs.

success HCTZ not only lowers my blood pressure and pulse more effectively. but it also has helped with the headaches ive been having. i should see a doctor about this.

[color="#0000FF"]rx: klonopin .5-1 prn, omega 3 fish oil, vitamin D3 iu, albuterol sulfate inhaler, magnesium hydroxide(for the constipationg)

in flux: seroquel 50mg
up and coming: nuvigil

looking into injectables.


artane 2 mg PRN(rare), trazodone 50mg PRN, lyrica PRN?





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#32 VAL

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Posted 02 March 2009 - 01:16 PM

It kicked in very rapidly for me as well.
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Current Meds: Lamictal 325mg, Wellbutrin XL 450mg, Neurontin 900mg, Klonopin 1.5mg, Saphris 10mg, Trazodone up to 200mg, Prozosin 2mg, Zyprexa 5mg PRN and Inderal 20mg PRN
Past Meds: Siniquan, Elavil, Imipramine, Zoloft, Seroquel, Abilify, Nardil, Emsam, Rozerem and Ambien
Current Non-psych: Soma 350mg PRN, Norco 10mg/325 PRN, Percocet 10mg/325 PRN, Advair, Nasonex, Ventolin PRN, Allegra, Avalide, Dexilant, Levothroxine, Pravachol


#33 In_Remission_sleepygoat

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Posted 12 April 2009 - 03:41 AM

Hi. Anyone tried or using SAM-e? Cheers,

I'm taking 1400 mg a day of Sam-e. My psychiatrist is fine with this, as the other SSRI's i've tried has sexual side-effects and flattened affect. SAM-e does not.
Here's the thing, though. I am certain that SAM-e is causing weight gain at this dose. I gained about 2 lbs a month since I started. (4 months = 8 lbs.) I should be losing weight as I am an even higher dose of armour thyroid than before, i jog 3 miles a day, and was eating 1300 cals a day (I'm 5'1"). Instead, weight gain. I attempted to wean to a lower does of SAM-e (800mg) and started wellbutrin at the same time - all under my doc's care. after 10 days (the same time it took for the SAM-e to start working in the fist place), I crashed bad. Total severe depression which I had not had for 4 months while on the full dose of SAM-e. My doc predicted it could happen because SAM-e targets serotinin, and wellbutrin doesn't, and I clearly have shown her over the years that I need something that targets serotonin. So I'm back on 1400 mg of sam-e, no wellbutrin (too much insomnia anyway) and I'm starving myellf now. jeesh. I hate this stuff.

#34 Katyusha

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Posted 12 August 2009 - 02:13 PM

GABA did nothing for me. 100mg, 1000mg, anything. And this makes sense, given the blood-brain barrier.
If I wanted to tickle my GABA receptors I should've just poured a scotch. (j/k)

SAM-e, on the other hand, has basically helped for a couple months. I get out of bed eventually most days, I'm not a mess every waking moment. It's not adequate function for a life or a career, but it keeps me safe.

Tried to stop the SAM-e previously, tapering off ("maybe it's all a placebo and this expensive stuff doesn't actually work!")...and found myself back to square one.

I take 1600mg ("and if I actually have bipolar, I'll sure find out with that dose") divided into two doses. First I take 800mg SAM-e with 200mg caffeine and 750mg DL-phenylalanine, upon waking, and that little nuclear blast gets me out of bed...within two hours. Then another 800mg on an empty stomach in the afternoon.

I'll have to stop SAM-e and DL-phenylalanine in order to start an MAOI (hopefully that will help me actually function), but SAM-e has been a minor stopgap in the meantime.

Here's a few bits of advice I learned on taking SAM-e. Haven't been well enough to track sources so take or leave this FWIW...

(1) Get it blister-packed and enteric-coated. SAM-e is unstable and breaks down quickly when exposed to air. So that bottle o' SAM-e you bought is nearly useless. SAM-e is absorbed by your small intestine, so you need to get enteric-coated tablets or your stomach acid will chew SAM-e up before you get any use out of it.

(2) There seems to be (according to reviews on Amazon and elsewhere, so - grain of salt) a wide range of efficacy among different manufacturers. FWIW, I read that Nature Made uses the same Italian manufacturer that produced the SAM-e for the European clinical trials. (I read that after I discovered for myself that I prefer Nature Made - others don't feel the same.) YMMV of course.

(3) Take on an empty stomach. First thing in the morning is good. You may get a little nauseated at higher doses. Doesn't seem to work with food (for me).

(4) SAM-e is stimulating (generally). On the plus side, that means it's probably good for fatigue associated with depression. It did give a little shock to my leaden paralysis (along with caffeine and DLPA).

(5) Apparently it works more quickly than the SSRIs, if it's going to work. (I get this factoid from Julia Ross, Daniel Amen, another book on SAM-e, and personal experience.) I'd give it a week to work, maybe two weeks at the most. I felt something within three days.

Edited by Katyusha, 16 November 2010 - 01:54 PM.

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#35 In_Remission_LSDisfucked

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Posted 17 January 2010 - 03:54 AM

from what I've read, it is important to get a histamine serum blood test before trying sam-e or methionine because they both reduce histamines in the brain. Too low of a drop in histamines can produce 'histapenic' symptoms, similar to BPD and schizophrenia. The reduction of histamines is what gives way to the changes in neurotransmitters that produce mood changing qualities of this supplement. My histamine are not high but just above middle of the road.

I think I'll try 200 to 400 mgs a day to start out. Question though, for those whom Sam-e has worked for, what does it do to your anxiety? Increase or decrease. If this is a stimulating drug I worry that it would increase anxiety and I definitely want to avoid that.

Edited by LSDisfucked, 17 January 2010 - 03:57 AM.


#36 dymphna

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Posted 28 October 2011 - 12:44 AM

Consumer labs tracks what brands don't have what they say they do. They release that the following brands don't have jack:

Integrative Therapeutics Inc. Vitaline® SAMe

Maxam Nutraceutics SAMe

Also: the pet product S-Adenosyl 100, distributed by Sogeval labs (since many people give this to their dogs for joint pain).

Studies for Sam-E related to depression. The consensus appears to be that it is a substance with properties similar to those of tricyclic ADs, and tend to be used when traditional treatments have failed.


Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies.


Double-blind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women.


Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. (this one had someone who had an initial manic episode induced by the substance)


S-Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial


Discrepancy in Response and Remission Rates
for SAMe-Treated Patients in a Double-Blind,
Randomized Clinical Trial


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eqnmrt.jpg

 


#37 notfred

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Posted 28 October 2011 - 03:47 PM

I'm not criticising SAM-E, but I was advised against taking products like it with my meds. For me, it doesn't pay to be my own shrink. With all the money I spend on a pdoc and scripts, I expect to see some results at least, from them, without going to additional expense on stuff that may or may not benefit me. Sam-E isn't cheap.



Things like SAM-e and Saint Johns Wort do have effects on people, often at the same sites prescribed psycomeds do. This is asking for a interaction where one of the meds (SAM-e) is not well studied.

nf
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Dx: Major Depressive Disorder, Attention Deficit Disorder PI, Refractory Insomnia, CSA, Temporal Lobe Epilepsy, Dyspraxia, Tremor
Psyc meds: Aplenzin 522 mg, Abilify 15 mg, Vyvanse 70 mg, Lunesta 6 mg, Levetiracetam 2000 mg, Propranolol ER 60 mg
Other: Fenofibrate, Atorvastatin, Lisinopril, Hctz, Asprin, Metformin, Januvia, Ranitidine, Cetirizine, Nasalide, Montelukast
PRN's: Lorazepam, Alprazolam, Dextroamphetamine, Propranolol, Cyproheptadine, Patanol, Prednisone, Ipratropium, Ondansetron, Hydrocodone, Doxepin
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#38 dymphna

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Posted 29 October 2011 - 02:10 AM


I'm not criticising SAM-E, but I was advised against taking products like it with my meds. For me, it doesn't pay to be my own shrink. With all the money I spend on a pdoc and scripts, I expect to see some results at least, from them, without going to additional expense on stuff that may or may not benefit me. Sam-E isn't cheap.



Things like SAM-e and Saint Johns Wort do have effects on people, often at the same sites prescribed psycomeds do. This is asking for a interaction where one of the meds (SAM-e) is not well studied.

nf


It's studied - like I put above - they found that that the actual substance does basically what a tricyclic will do. At a higher cost, with a longer time to onset, and more variable results. Oh, and you will never know if you're actually getting the real substance or rat poison.


D
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Yes, my name really is Dymphna.

 

I'm not a doctor, nurse, pharmacist, or therapist.

I can find you an answer and I won't blow smoke up your ass.

 

St. Dymphna is the Patron for brain maladies.

 

I'm the Enforcer.

 

eqnmrt.jpg

 


#39 ClaudiaP

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Posted 17 March 2012 - 11:55 AM

Yup, to whomever asked, kicked right the fuck in. As for how it compares to a tricyclic, I can only compare to flexoril (sp?), which I took as prescribed for a while after some surgery without realizing it was a tricyclic, big mistake almost ruined my life and wound up sending me from being a relatively low-maintenance BPII person on monotherapy to something more complicated apparently forever. Flexoril made me nice and relaxed and sleepy for a few days and then wham suddenly horribly mixed state hypomanic and suicidal (I'd been this way without drugs at times, but this was a big slam). SAM-e at a split pill, 100mg with lithium and lamotrigine and topomirate immediately seemed to make me feel more alert and focused. Not necessarily cheery but more capable and able to sort through the rather overwhelming tasks in front of me and just to get out of bed, which was refreshing. However, although my thoughts aren't racing as they were with the flexoril, I'm, after about a week having trouble sleeping. As in, not sleeping. And then not feeling tired. So I assume this isn't good. But I really don't want to lose this alertness, because I happen to really need it. I have a huge frickin deadline and some serious spotlight pressure and I need to get some stuff done. I need *some* kind of attention boost, because something's been inordinately wrong of late (about 1.5 yrs) and this stuff was nicer than caffeine--just focus, no race.
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#40 chrislikes2pharm

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Posted 17 March 2013 - 08:27 PM

Hi. i started SAMe(S-adenosylmethionine) back in 03 or 04 at 400mg daily. Taking it was a gamble to reduce my anxiety related to pure obssessional OCD. It worked immediately. It took the edge off my anxiety. I recently reduced the dose to 200mg to save money and there has been no change to my mental picture. I found that it is cheap and effective(for me and maybe not for you) at Swanson Vitamins online. 60 200mg is 14.99 there. I have had no side effects that I know of. I think it augments the SSRI I take, Luvox which I have taken for 17(seventeen!) years. I am not recommending it for anybody just sharing a positive experience.


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#41 DaraQW

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Posted 18 March 2013 - 01:42 PM

Just found this site because I was searching form more info on SAM-e. I've been transitioning off Celexa (citalopram) for the past month. I've been on it for probably ten years now as a prophylactic to avoid experiencing a second major depressive episode (after 6 years of zoloft, which quit working) and, aside for the sexual side effects, it's worked fine. However my meds doc has said she wants me off it in the next five years (before I hit 60) because of some studies that now show it can adversely affect heart rhythm. My personal interest in getting off of it is so that I no longer have to shell out major bucks for meds management annually. I have enough sense and experience now to manage my own meds and would like the option of seeing a psychiatrist only when a change is needed. I have endocrine issues and already have regular labs for just about everything under the sun and regular primary care and specialist visits. I also do phototherapy during the darker months.

 

My experience with SAM-e (taken with a B vitamin supplement--my research indicated this was necessary and since B vitamins are harmless/water soluable, it was a no brainer) so far has been good. I have been doing the see-saw act of reducing my citalopram dosage while systematically upping my SAM-e.  I began with 400 mg/day of SAM-e while still on 30 mg/day of the citalopram. After two weeks, I cut my citalopram to 20 mg a day. I noticed I didn't feel as well as usual (my signs of under-medication: inability to concentrate, make decisions, focus, sleep disturbance, IBS-like symptoms) so I immediately upped the SAM-e to 800 mg/day and felt a bit better but not great for about a week, after which I noticed some improvement. I again upped the SAM-e to 1200 mg. After a week, I lowered my citalopram to 10 mg/day which is where I am now. My sleep is better than it has been in some time (on just the citalopram it was sometimes not easy to fall asleep) and I have more energy during the day. I am cautiously optimistic that SAM-e is going to be a more-than-satisfactory replacement for my prescription  SSRI. It's not going to cost me a lot less money but that doesn't bother me. What I am somewhat jazzed about is that I may even feel BETTER than I have for a long time. 


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