4 replies to this topic

[dymphna]

While I was on Seroquel (25-50mg for sleep) I developed a sore nipple...no discharge. I saw my ob/gyn had an exam, mammogram...nothing, just a tender spot.

I've read about prolactin levels rising with other APs, but haven't found anything indicating that this happens with SQL. (I have read all the other posts in this forum discussing spotting and heavy periods etc...) The strange thing is...when I stopped taking Seroquel last month - within days and lasting more than a week -I got major estrogen dominant symptoms...very sore breasts. (it's been years since I had any symptoms like this. I had a hysterectomy in my 30's. Kept the ovaries and they seemed to keep working until about 4-5 years ago...since then I've been menopausal...I'm 51).

In any case, I'm back to taking 12.5-25 mg...for sleep and attitude adjustment...so far no tender anything....maybe it was a coincidence.

L

Seroquel can raise prolactin levels, just not to the same level as something like Risperidone.

Raised prolactin levels can account for sore spots, heaviness without causing any noticeable leakage.

Presence or absence of hysterectomy is actually irrelevant in regards to this as prolactin is secreted by the pituitary gland, and is not affected by the ovaries.

The concept of estrogen dominant symptoms, though is strange. You may be confusing "estrogen dominant" with a prolactin surge. In the presence of a prolactin surge, the breasts will become "fuller", and then "deflate" somewhat once the prolactin surge is mediated by either removing the dopamine antagonist (Seroquel, Risperdal, etc.) or, in the absence of an AAP, by adding in a dopamine agonist.

As your symptoms are surfacing in the absence of your AAP, I would suggest seeking out an endocrinologist.


Dymphna