Lyrica
#1
In_Remission_eric68
Posted 22 February 2008 - 08:54 AM
#2
In_Remission_rayovac
Posted 22 March 2008 - 05:04 PM
I was recently diagnosed with Bipolar II wo co-morbid GAD and panic disorder. I'm always looking for the next advancement in anxiety management and I've read that Lyrica has been approved for GAD in Europe, though not here in the U.S. I'm interested in learning about anyone's experience with Lyrica to manage anxiety and panic. Would it be worth asking my pdoc about it? Thanks for your input.
In my experience: GAD - yes, Panic - probably not (maybe)
If you've ever taken neurontin, then you'll know what to expect with Lyrica. The difference (in my opinion) is that Lyrica is far more reliable and far more predictable. There aren't so many bioavailability issues, and its effects *are* dose - dependent in a more linear fashion (in other words, 400mg = twice the effect of 200 mg, 800mg = twice the effect of 400mg). Lyrica can really pack a whallop....and at the right dose I can see it kicking any anxiety cold. This is (I believe) the reason that it is scheduled.
Also (in my opinion) while Lyrica is probably effective for GAD, it seems to function much more like a mood stabilizer.
I actually love the stuff, it has helped me with pain issues and mood...but I'm an odd one.
Good luck!
#3
In_Remission_rand84
Posted 06 April 2008 - 04:28 PM
My doctor just prescribed me Lyrica for my OCD/anxiety. I am currenlty on 200mg of Zoloft, how does Lyrica help with my problem? If it just will turn me into a zombie I don't want to take it. Any thought on this medicine?
Edited by rand84, 06 April 2008 - 04:28 PM.
#4
In_Remission_loona
Posted 10 April 2008 - 01:33 AM
Oh, before switching to Lyrica, I'd been on Neurontin with pretty much the same effect, only I'd have to take boatloads of the pills because of bioavailability issues as someone upthread mentioned. NOTE: I gained about 30 lbs while on Lyrica!!! This has taken about six months. My psychiatrist says 40lb weight gains are not unheard of, so she's going to start me on Topamax rather than switch back to Neurontin. It might also have been that my insurance company wouldn't pay for Neurontin, but would pay for Lyrica? To be honest, I don't remember why she's so anti-Neurontin (relatively speaking), but I think I'd rather just go back to Neurontin than add another med to the mix... On the other hand, I just started Lithium so that might mean a losing battle against the weight gain unless we do use the Topamax.
#5
In_Remission_crazyhed
Posted 18 May 2008 - 10:43 AM
I take both a benzo and lyrica for anxiety. I had the kind of anxiety that was felt very much in the gut/chest - just a feeling in the torso of being intensely startled, but constantly, actually more of an akathisia, and Lyrica is the only thing that stopped it. Praise be! So for me, the benzos work from the neck up (they help with anxious thoughts) whereas the lyrica really nails the anxious sensations.
Oh, before switching to Lyrica, I'd been on Neurontin with pretty much the same effect, only I'd have to take boatloads of the pills because of bioavailability issues as someone upthread mentioned. NOTE: I gained about 30 lbs while on Lyrica!!! This has taken about six months. My psychiatrist says 40lb weight gains are not unheard of, so she's going to start me on Topamax rather than switch back to Neurontin. It might also have been that my insurance company wouldn't pay for Neurontin, but would pay for Lyrica? To be honest, I don't remember why she's so anti-Neurontin (relatively speaking), but I think I'd rather just go back to Neurontin than add another med to the mix... On the other hand, I just started Lithium so that might mean a losing battle against the weight gain unless we do use the Topamax.
I also recently experienced a 30+ pound weight gain in 2-3 weeks on a high dose of Lyrica (for leg pain). Though some of the weight could be attributed to an increased appetite/intake from Seroquel, I believe most of the weight gain was water weight due to water retention, as evidenced by feet and ankle edema, which resolved with discontinuation of the Lyrica.
As a side note, you mentioned an anxious sensation in your chest/gut... I suffered from what I can only describe as a burning pit in my stomach/chest last year (a few months before my wedding) and was suprised to learn that it was anxiety which was totally abated with the use of Buspar... which I was able to discontinue shortly after this major life event!
Hope this was useful to someone. Good luck to all.
#6
Posted 04 July 2008 - 12:51 AM
Lyrica is worth a try.
It don't matter if I get a little tired
I'll sleep when I'm dead"
Warren Zevon
#7
In_Remission_Nuttin-Works
Posted 13 September 2008 - 03:43 PM
Although I didn't realize it, after taking it for a week, every part of my body was numb except for my migraine. I guess that's why we bleed, so we will see it.
#8
In_Remission_Porter
Posted 18 September 2008 - 01:48 PM
#9
In_Remission_daisy
Posted 23 October 2008 - 09:15 AM
#10
Posted 23 October 2008 - 12:03 PM
I knew I was starting this drug, so I made a conscious effort to track my food intake (I didn't go on a diet, I just started monitoring what was going in my mouth and not "grazing"). I am currently taking 75mg BID for over a month and have gained no weight. I have no edema to speak of. I am on another weight gainer and have more to worry about from it (cabergoline - it is a long, slow, steady climb).
I have noticed that simple carbs make me feel like shit and proteins make me feel better. I have to balance this with the fact I'm on two CAIs and need to keep my kidneys.
Everyone is different.
Oh, once it reached a decent plasma concentration, it did help level my mood. I'm not an anxious person by nature, but I am a manic one, and it quelled that, FWIW.
Dymphna
Yes, my name really is Dymphna.
I'm not a doctor, nurse, pharmacist, or therapist.
I can find you an answer and I won't blow smoke up your ass.
St. Dymphna is the Patron for brain maladies.
I'm the Enforcer.

#11
Posted 23 October 2008 - 03:47 PM
Meds: 30mg Dexedrine Spansule .. 200mg Lamictal .. 80mg Latuda .. 600mg Neurontin .. 200mg Ultram ER
Some people say the grass is always greener on the other side.
I say be the gardener. Water it. Feed it. Make your own grass grow.
I make the grass greener wherever I am. I'm the gardener.
#12
Posted 24 October 2008 - 01:16 AM
My Neurologist/Muscle Doctor/Shoulder Doctor/Pdoc are all working together on this. I take it for severe nerve damage in my shoulder/anxiety.. titrating up.. and I can tell that it's working already. I've been reading up on the drug interactions between Lyrica and Topamax.. the pharmodynamic interactions, not the side effects.. and they enhance each other. It's pretty interesting. Way off topic, not meaning to thread jack.
oooo.... that is good to know. Any cites?
D
Yes, my name really is Dymphna.
I'm not a doctor, nurse, pharmacist, or therapist.
I can find you an answer and I won't blow smoke up your ass.
St. Dymphna is the Patron for brain maladies.
I'm the Enforcer.

#13
Posted 24 October 2008 - 01:10 PM
Meds: 30mg Dexedrine Spansule .. 200mg Lamictal .. 80mg Latuda .. 600mg Neurontin .. 200mg Ultram ER
Some people say the grass is always greener on the other side.
I say be the gardener. Water it. Feed it. Make your own grass grow.
I make the grass greener wherever I am. I'm the gardener.
#14
In_Remission_daisy
Posted 25 October 2008 - 04:37 AM
thanks daisy
#15
Posted 25 October 2008 - 07:53 AM
Dosages are the daily total. Most meds are taken in smaller doses throughout the day.
Past meds: I've tried almost everything except MAOI's, half of the TCA's, Clozaril, Remeron and Serazone.
#16
Posted 25 October 2008 - 08:31 AM
Have you tried Neurontin?
Meds: 30mg Dexedrine Spansule .. 200mg Lamictal .. 80mg Latuda .. 600mg Neurontin .. 200mg Ultram ER
Some people say the grass is always greener on the other side.
I say be the gardener. Water it. Feed it. Make your own grass grow.
I make the grass greener wherever I am. I'm the gardener.
#17
In_Remission_daisy
Posted 26 October 2008 - 04:36 AM
daisy
#18
Posted 27 October 2008 - 05:19 AM
unfurtunately you have to give it a fair chance..I can't really say if it worked well for pain or anxiety as I never gave it much of a chance!
daisy
it only kicks in after about 5-7 days
rx:::Carbamazepine 400TID::Risperidone 2mg::Gabapentin 800Qid::Dothiepin HCI 150:
#19
In_Remission_theswan
Posted 08 December 2008 - 01:18 PM
Daisy! Wow! I've been looking for someone that had the same effect as I did on Lyrica. I used it two years ago and it lasted six months (as effective) It like in your case, wore off. I used it again in August 2008 and it lasted 21 days! Auugh!
I went off for twenty days or maybe a bit like 16 days and I got it filled by accident as I called in all my medications to the pharmacy (including diabetes drugs etc) I said "what the heck" and tried it again. Well here I am at day 3 and I feel great again. I don't feel "high" just normal with a lot of energy. My chronic pain is down as is my anxiety and depression.
Gee whiz, this drug is a darn near wonder drug except that as you said-"peters out" I wonder why and if increasing the dose to over 300mg would be of benefit?
Maybe we should write to the company. My doctor says he is not sure why it works so well other then just plain tolarence. I seem to remember that when I went up from 75mg TID to 150mg BID, it made no difference. It did not start to work again when I increased it.
Maybe just weaning off and going back on is the way to go? Darn it-I'll just enjoy the benefit for now Lol
Glen AKA theswan
#20
Posted 02 August 2010 - 07:46 AM
Edited by horselover, 02 August 2010 - 10:25 AM.
Current meds:
Viibryd 20/40mg
Abilify 10mg
Lamotrigine 100mg
levothyroxine 0.05mg
Protonix 40mg qam for GERD
Ativan 0.5mg prn
Previous meds.:
Lexapro
Pristiq
#21
Posted 02 August 2010 - 11:52 AM
Wow. I guess I'm just a case study for this drug. Neurontin was horrible for me, but Lyrica actually works as advertised (seizures).
I knew I was starting this drug, so I made a conscious effort to track my food intake (I didn't go on a diet, I just started monitoring what was going in my mouth and not "grazing"). I am currently taking 75mg BID for over a month and have gained no weight. I have no edema to speak of. I am on another weight gainer and have more to worry about from it (cabergoline - it is a long, slow, steady climb).
I have noticed that simple carbs make me feel like shit and proteins make me feel better. I have to balance this with the fact I'm on two CAIs and need to keep my kidneys.
Everyone is different.
Oh, once it reached a decent plasma concentration, it did help level my mood. I'm not an anxious person by nature, but I am a manic one, and it quelled that, FWIW.
Dymphna
I'm going to update this post.
When I hit 100mg BID all hell broke loose. My electrolytes went to hell. I swelled up like a balloon. I started seizing like there was no tomorrow.
The Ndoc didn't want to hear any of it - he just thought I was being a bitchy woman. I went off of it all at once while in hospital for a Veeg (thank god). No one was ever able to tell me what the hell happened.
Dymphna
Yes, my name really is Dymphna.
I'm not a doctor, nurse, pharmacist, or therapist.
I can find you an answer and I won't blow smoke up your ass.
St. Dymphna is the Patron for brain maladies.
I'm the Enforcer.

#22
Posted 02 August 2010 - 09:02 PM
Wow. I guess I'm just a case study for this drug. Neurontin was horrible for me, but Lyrica actually works as advertised (seizures).
I knew I was starting this drug, so I made a conscious effort to track my food intake (I didn't go on a diet, I just started monitoring what was going in my mouth and not "grazing"). I am currently taking 75mg BID for over a month and have gained no weight. I have no edema to speak of. I am on another weight gainer and have more to worry about from it (cabergoline - it is a long, slow, steady climb).
I have noticed that simple carbs make me feel like shit and proteins make me feel better. I have to balance this with the fact I'm on two CAIs and need to keep my kidneys.
Everyone is different.
Oh, once it reached a decent plasma concentration, it did help level my mood. I'm not an anxious person by nature, but I am a manic one, and it quelled that, FWIW.
Dymphna
I'm going to update this post.
When I hit 100mg BID all hell broke loose. My electrolytes went to hell. I swelled up like a balloon. I started seizing like there was no tomorrow.
The Ndoc didn't want to hear any of it - he just thought I was being a bitchy woman. I went off of it all at once while in hospital for a Veeg (thank god). No one was ever able to tell me what the hell happened.
Dymphna
Sorry to hear you had such an bad response. What were you taking Lyrica for? What was your target dose? Just wondering since you had some positive response @75mg BID. Were you taking any other meds at the time? I understand neurontin has more of a drug interaction profile than lyrica.
And thanks for your update.
Current meds:
Viibryd 20/40mg
Abilify 10mg
Lamotrigine 100mg
levothyroxine 0.05mg
Protonix 40mg qam for GERD
Ativan 0.5mg prn
Previous meds.:
Lexapro
Pristiq
#23
Posted 02 August 2010 - 10:25 PM
Sorry to hear you had such an bad response. What were you taking Lyrica for? What was your target dose? Just wondering since you had some positive response @75mg BID. Were you taking any other meds at the time? I understand neurontin has more of a drug interaction profile than lyrica.
And thanks for your update.
It was prescribed for epilepsy. I don't know what the Ndoc's target dose was going to be. I was also on Diamox CR, Topamax, and Cabergoline.
D
Yes, my name really is Dymphna.
I'm not a doctor, nurse, pharmacist, or therapist.
I can find you an answer and I won't blow smoke up your ass.
St. Dymphna is the Patron for brain maladies.
I'm the Enforcer.

#24
Posted 07 September 2010 - 04:09 AM
Anyone currently using Lyrica for anxiety? Anyone using it for anxiety that has BP and Aspergers/autism? I would love to hear some new responses since these were a while back. Thanks
I have used Lyrica for anxiety and migraine prophylaxis for nearly a year now. At first it worked miracles for both, but then it either 'pooped-out' or my anxiety and migraines just got worse. I am going to try to up the dosage to 450 mg (higher than the average maximum dose of 300). I experience zero side-effects from it except the "can't remember the right word" and maybe some other forgetfulness, but I'm fine for that, at least until graduate school. I never knew it could cause weight gain! Right now I'm on 200 mg Wellbutrin SR, 10 mg Lexapro (trying to combat sexual side-effects), 350 mg of Lyrica, Xanax XR, and, at the moment, 50-100 mg Seroquel for sleep, and I wish I could gain weight. I've been smoking heavily so that's part of the problem, but at 5'5" and 107 lbs people are starting to say I look sick. (I have a small build though.)
I'm keeping a blog that discussed my dosage upping of Lyrica if you're interested.
- Jonathan Safran Foer, "Extremely Loud and Incredibly Close"
#25
Posted 18 September 2010 - 06:20 PM
Lyrica should NOT be allowed on the market. Maybe for fibromyalgia but that's all. Any doctor who prescribes it should have to retake his state boards because he is just listening to the pharmacy rep who never passed either high school chemistry or biology.
Although I didn't realize it, after taking it for a week, every part of my body was numb except for my migraine. I guess that's why we bleed, so we will see it.
@Nuttin-Works, your post makes a broad sweeping generalization that shows a lack of effort on your part to partake in an intelligent discussion of a complex topic. Saying things like that doesn't add anything positive to the discussion and gives people unjustified fear.
Just because a med has a certain effect on YOU does not mean that it will affect everyone like that. Please try to refrain from saying hugely exaggerated things like "Any doctor who prescribes it should have to retake his state boards because he is just listening to the pharmacy rep who never passed either high school chemistry or biology."
To those who are considering trying Lyrica, don't let the fear-mongering posts dissuade you from trying a drug that may change your life for the better. Everyone reacts differently to meds and you won't know for sure how you'll respond to a med until you actually try it.
Diagnosis: Chronic Pain (back / hips / thighs / buttocks), Anxiety, Depression (in remission), ADHD-I (Predominantly Inattentive Type)
Current Meds (in daily doses): Savella (milnacipran) 50mg AM / 50mg PM; Remeron (mirtazapine) 135mg PM; Klonopin (clonazepam) 1mg AM / 1mg PM (plus up to 6mg/day more PRN); Wellbutrin (bupropion) 150mg; Namenda (memantine) 20mg; Zanaflex (tizanidine) up to 16mg/day PRN; Nuvigil (armodafinil) occasionally 125mg AM
Past Meds: Lexapro (escitalopram); Cymbalta (duloxetine); Strattera (atomoxetine); Abilify (aripiprazole); Neurontin (gabapentin), Pristiq (desvenlafaxine), Valium (diazepam), Risperdal (risperidone), Adderall (amphetamine salts), Lyrica (pregablin), Opana (oxymorphone), Ultram (tramadol), DXM a.k.a. dextromethorphan 150mg AM / 150mg PM (based off the Brand-name med Nuedexta)
#26
Posted 19 April 2011 - 06:34 AM
I am not anxious all the time. I get social phobia/other phobias, and panic associated with phobias plus Low mood. Would it be bad to start this first and see where it helps?
I am relying on Klonopin PRN, and notice I seem to get my moods set off, if I take it PRN. I can take it daily but I don't want to rely solely on a benzo.
It would be nice to feel a little more even keel, and less anxious.
Juno: You know, pretty solid! So have you started on that paper for Wart's class yet?
Su Chin: No, I tried to work on ot a little last night but I couldn't concentrate.
Juno: Well I can sell you some of my Adderal. If you want.
Su Chin: No thanks. I'm off pills.
Juno: Thats a wise choice. Because I like knew this girl who had like this crazy freak out from taking too many behavirol meds at once. And she like ripped off her clothes, and dove into the fountain at Ridgedale mall and was like, "Blah I am a krackin from the sea!"
Su Chin: I heard that was you.
#27
Posted 19 April 2011 - 06:48 AM
I think it'd be worth a shot. It doesn't give you the kind of feeling a benzo does, but for me I just feel a bit calmer and more in control over the anxiety.
As a general rule, people, even the wicked, are much more naive and simple-hearted than we suppose. And we ourselves are, too.
-Fyodor Dostoevsky, The Brothers Karamazov.
Current Meds: Strattera 40mg, nortriptyline 25mg, Lyrica 75mg, lithium 600mg daily, Maxalt 10mg PRN, diazepam 5-10mg PRN, Reclipsen .15/.03 (OCP)
+ Fish Oil (800mg EPA 400mg DHA),Magnesium Oxide 750mg, Vitamin D3 2000 IU
Ex-Meds:
ADs: Paxil, Zoloft, Effexor, Lexapro, Wellbutrin, Cymbalta, Celexa, amitriptyline, lofepramine (mostly awesome--wish it were in the US), Prozac.
Benzos: Klonopin, Ativan, Tranxene
AAPs: Abilify
ACs: Lamictal, Neurontin (great for anxiety), Topamax (3 days)
Triptans: Zomig, Imitrex, Treximet
Others: Midrin, Nadolol, Propanolol, Clonidine
0 user(s) are reading this topic
0 members, 0 guests, 0 anonymous users












