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Zyprexa Twice A Day?


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#1 Revan

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Posted 29 August 2012 - 07:28 AM

Does anybody out there take olanzapine twice a day instead of it all at once?

I ask because I am on 2.5mg olanzapine at night (I take it about 8pm) for anxiety and agitation. It seems to work well but I could swear it feels like it's wearing off around about 10 AM (I get up at 5AM). I wonder if taking another dose in the morning could help that.... I remember when I was on risperdal we had to space the dose out to twice a day. Perhaps this is what is happening here?
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#2 Rodger O'Connor

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Posted 29 August 2012 - 08:15 AM

I take 2.5 twice a day. Like you, I found that I needed to space it out.
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#3 apetasticaL

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Posted 10 May 2013 - 11:56 AM

I have been wondering about this myself. I take 10mg at night but it feels like it has worn off during the daytime. Maybe I could split my pills and take 5mg in the morning and 5mg at night? I am curious if this would work better because right now I feel like I am just wasting the Zyprexa.
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smiling despair. no solution, but constantly exercising an authority over myself that i know is useless. the essential thing is not to lose oneself, and not to lose that part of oneself that lies sleeping in the world. -albert camus

axis I dx: bipolar NOS
rx: lamotrigine 200, aripiprazole 15, topiramate 100

past rx: lithium carbonate, divalproex sodium, gabapentin, levetiracetam, paroxetine, fluoxetine, doxepin, trazodone, quetiapine, paliperidone, ziprasidone, risperidone, olanzapine, trifluoperazine, methylphenidate, phenobarbital, chlordiazepoxide, diazepam, clonazepam, lorazepam, temazepam, buspirone, hydroxyzine, zolpidem, ramelteon

#4 apetasticaL

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Posted 15 May 2013 - 06:12 AM

I have been wondering about this myself. I take 10mg at night but it feels like it has worn off during the daytime. Maybe I could split my pills and take 5mg in the morning and 5mg at night? I am curious if this would work better because right now I feel like I am just wasting the Zyprexa.


I have started taking my Zyprexa this way. So far, I have noticed a generally more relaxed mood. I don't have to take my Klonopin until later in the day, which is always a good thing. No unwanted sedation, either. It seems to be a good choice.

(YMMV of course)
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smiling despair. no solution, but constantly exercising an authority over myself that i know is useless. the essential thing is not to lose oneself, and not to lose that part of oneself that lies sleeping in the world. -albert camus

axis I dx: bipolar NOS
rx: lamotrigine 200, aripiprazole 15, topiramate 100

past rx: lithium carbonate, divalproex sodium, gabapentin, levetiracetam, paroxetine, fluoxetine, doxepin, trazodone, quetiapine, paliperidone, ziprasidone, risperidone, olanzapine, trifluoperazine, methylphenidate, phenobarbital, chlordiazepoxide, diazepam, clonazepam, lorazepam, temazepam, buspirone, hydroxyzine, zolpidem, ramelteon

#5 notfred

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Posted 15 May 2013 - 10:11 AM

Unlikely with a half life of 21–54 hours.


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I am in full remission (DSM IV 296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Aripiprazole 15 mg (Abilify), Eszopiclone 6 mg (Lunesta), Belsomra 20 mg (Suvorexant), Vyvanse 70 mg (Lisdexamfetamine), Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal), Clonazepam 1 mg (Klonopin),
PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8-16 mg (Zofran)

Supps: Multi-vitamin/mineral, Vitamin D-3 2,000 IU, Omega-3-acid ethyl esters 4 g (Lovaza), Hemp seed oil 2 g (ALA), CoQ10 100 mg, L-Glutathione 200 mg, Iron 65 mg (Ferrous Sulfide)

Dx: Depression, Insomnia, ADHD-PI, Temporal Lobe Epilepsy, Dyspraxia, Tremor, Iron and Vitamin D deficient 

I also take allergy and diabetes + it's complications meds, Truvada

All doses are a daily total.


#6 pdv

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Posted 23 May 2013 - 10:54 AM

Initially, my neurologist prescribed it 3 times a day.. 2.5-2.5-5mg. Now am taking it twice a day which is better.



#7 xbmcx

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Posted 23 May 2013 - 09:09 PM

I took it once a day, but have heard of others taking it twice a day. I am currently on Saphris and am having the same dilemma. It is actually indicated on the PI to be taken twice daily, yet it boasts a half-life of 25 hrs.. I have asked three different pdocs about this (my clinic keeps switching me around), and they all say that it is fine to take once a day and that, that is usually how they prescribe it but that I could take it twice a day. I have been, and it has been helping but I feel more blunted cognitively. Ugh, I guess that is the trade off...


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Dx: Bipolar-NOS or I (depends who you talk to!), GAD, OCD, Eating Disorder - All, and possible ADD;

Rx: Saphris - 10mg, lithium ER 300mg, Lamictal - 100mg, Lyrica - 100mg TID, , Cymbalta - 60mg Klonopin - 1mg.

Past Rx (alone and in various combos): Zyprexa, Geodon, Risperdal, Abilify, Trileptal, Lithium, Neurontin, Luvox, Prozac, Zoloft, Celexa, Lexapro, Effexor, Wellbutrin, Strattera, Concerta, Trazadone, Xanax, Ativan, Buspar


#8 pdv

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Posted 24 May 2013 - 12:54 AM

xbmcx,

 

cognitive dulling can happen. you should try and add modafinil. also, don't know about saphris but isn't so bad with olanzapine. also, lamictal can keep things in check.




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