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Lamotrigine And Paracetamol (Acetaminophen)


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7 replies to this topic

#1 Grin

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Posted 01 August 2012 - 01:11 AM

I think that would be Tylenol in the US.

Last week I went to the pharmacy to get something for headache, and I was given Dafalgan. Reading the PI sheet, I saw that they suggest not taking paracetamol if you're on anti-epileptics (unfortunately, I was abroad and the PI sheet was in French, so I wasn't able to understand every word, I just deciphered, under the section about drug interactions, something about "avoid" and "anti-epileptics").

But, reading the Lamictal PI sheet again, I found nothing on lamotrigine/paracetamol interactions. Googling it I found mixed results, some stating there are no interactions, others that there is possibility of hepatotoxicity.

Anyone know more about this?

Edited by Grin, 01 August 2012 - 01:12 AM.

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#2 VAL

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Posted 01 August 2012 - 01:09 PM

I only know that I've been taking hydrocodone with 500mg tylenol (lortab/vicodin) up to four times a day with my lamictal and my liver tests (every three months) have been normal for all the years I've been on both. Neither my pharmacist, pdoc or GP have ever hinted at a problem. I rarely take more than 2 lortab a day but have been allowed four. My pdoc is pretty smart and directs an addiction program so knowledgeable about both. The drugs.com interaction checker had no interactions listed.

Edited by VAL, 01 August 2012 - 01:10 PM.

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Current Meds: Lamictal 300mg, Wellbutrin XL 450mg, Neurontin 900mg, Klonopin 1.5mg,  Trazodone up to 300mg and Inderal 20mg PRN
Past Meds: Siniquan, Elavil, Imipramine, Zoloft, Seroquel, Abilify, Nardil, Emsam, Rozerem, Celexa and Ambien
Current Non-psych: Soma 350mg PRN, Norco 10mg/325 PRN, Percocet 10mg/325 PRN, Advair, Nasonex, Ventolin PRN, Allegra, Benicar, Dexilant, Levothroxine, Pravachol and Nexium. 


#3 Grin

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Posted 05 August 2012 - 02:45 AM

A few days ago I had neck pain and it got so bad I couldn't sleep, and Dafalgan was the only thing in the house, so I took 2x500mg. Nothing terrible happened.
It didn't help much though, so the next day I took some diclofenac, which gave me such a bad allergic reaction (face swelling) I ended in the ER. Life sure has a wicked sense of humor.
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Previously on : Cipralex, Risperdal, Effectin, Citalon, Coaxil, Olanzapine, Lamictal, Wellbutrin, Tegretol, Mapron, Lyrica, Edronax


#4 Blue Heron

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Posted 05 August 2012 - 08:55 AM

Sorry to hear you had a bad experience, Grin. Drug allergies are a bear.

Just for future reference: The drugs dot com interaction checker is a good place to start with questions about how safe it is be on two or more meds at the same time. It's not foolproof, but it can give you a frame of reference for determining how likely it is that you'll have problems with a particular cocktail.
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#5 Grin

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Posted 05 August 2012 - 10:04 AM

Thanks!
I tried drugs.com, and although it said no known interactions between lamotrigine/paracetamol, I found a Lamictal CD and it said this one does interact with acetaminophen/hydrocodone, so I wasn't sure.

The allergy luckily wasn't dangerous, no rash, itchiness, chest pain or difficulty breathing. But the swelling was very obvious and persistent and when it didn't change overnight I decided to have it checked out anyway.

Edited by Grin, 05 August 2012 - 10:26 AM.

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Previously on : Cipralex, Risperdal, Effectin, Citalon, Coaxil, Olanzapine, Lamictal, Wellbutrin, Tegretol, Mapron, Lyrica, Edronax


#6 VAL

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Posted 05 August 2012 - 11:55 AM

Hi Grin...what's a Lamictal CD? After trying many, many treatments and medicines for pain and after going about twelve years never taking any pain medicine, I finally settled on the Lortab as being the most effective with the least amount of side effects despite the potential for addiction and the problem with tolerance. I control for tolerance by going off it for a period of around two weeks every two months or so and using as little as possible the rest of the time.

Edited by VAL, 05 August 2012 - 11:57 AM.

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Current Meds: Lamictal 300mg, Wellbutrin XL 450mg, Neurontin 900mg, Klonopin 1.5mg,  Trazodone up to 300mg and Inderal 20mg PRN
Past Meds: Siniquan, Elavil, Imipramine, Zoloft, Seroquel, Abilify, Nardil, Emsam, Rozerem, Celexa and Ambien
Current Non-psych: Soma 350mg PRN, Norco 10mg/325 PRN, Percocet 10mg/325 PRN, Advair, Nasonex, Ventolin PRN, Allegra, Benicar, Dexilant, Levothroxine, Pravachol and Nexium. 


#7 Grin

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Posted 05 August 2012 - 12:01 PM

I don't know actually... I found it on drugs.com http://www.drugs.com...amictal-cd.html but I wasn't able to find out what's the difference from Lamictal.
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Currently on: Zoloft 400mg

Previously on : Cipralex, Risperdal, Effectin, Citalon, Coaxil, Olanzapine, Lamictal, Wellbutrin, Tegretol, Mapron, Lyrica, Edronax


#8 Blue Heron

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Posted 05 August 2012 - 02:51 PM

Lamictal CD is a chewable form of extended-release Lamictal, so it's supposed to be equivalent to Lamictal XR. Your mileage may vary, as usual.

The "CD" designation appears to stand for "chewable disintegrating."
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