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Melatonin And Prozac

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#1 jendaizbee


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Posted 25 April 2012 - 11:42 AM

Hey folks,

Does anyone have a clue how SSRI's like Prozac interact with Melatonin? I've been using Melatonin for about two years almost every night, because I have horrible insomnia. Lately, I've had to use ridiculous amounts some nights just to be able to sleep at all - I mean up to 50 mgs. (the highest form they come in over the counter that I've seen is a 10 mg capsule). I know this is abnormal and weird, as well as probably a bad idea. But my rheumatologist who I see for an autoimmune disease and Fibromyalgia told me "It's impossible to overdose on Melatonin" once, so, you know, I get desperate for sleep and take desperate measures.

My question is: I've been on Prozac for a couple of months now after going off Wellbutrin because I have mild OCDD and the Prozac helps with that. But I'm wondering whether or not taking all this Melatonin is counteracting the Prozac's effects on my Seratonin, or, if to the contrary, it's compounding the effects. Either way, I really have no clue about it.

Any information would be helpful.

I was on 60 mgs. of Prozac for a couple weeks because that's the recommended dose for OCD but my psychiatrist thought I was becoming hypmanic and so he reduced it back down to 40 mgs last week. Some nights I take 20 mgs of Melatonin but anything less than that fails to be effective - probably because I've been using it for so long.
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-Anne McIntyre, Flower Power


Dx: Schizoaffective Disorder, Bipolar Type

Current Meds: Trilafon, Clozaril (going off now), Prozac, Valium, Vistaril, Melatonin, Ambien, and non-psych meds for thyroid and Lupus

Past Meds: APs - Seroquel, Risperdone, Geodon, Abilify, Haldol and Thorazine (those 2 in hospitals)
Antidepressants: Prozac, Paxil, Effexxor, Anafranil, Elavil, Tofranil, Remeron 
 Prozac 50 mgs, Latuda 80 mgs, Clonazepam 1.5 mgs, Vistaril 100 mgs, Ambien 10 mgs, Risperdal Consta injections - 50 mgs biweekly, Melatonin for additional sleep help, other non-psych meds and other SSRI's I can't recall

Mood Stabilizers: Neurontin, Lithium, Lamictal, Depakote, perhaps others
Others: Luvox, Ritalin, Cogentin and others like it, Restoril, Trazadone plus more I cannot remember

#2 Shatneresque


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Posted 29 May 2012 - 07:32 AM

When I take melatonin, I have to stop for a few weeks to get the benefits, if I just keep taking it it actually disrupts my sleep. I'm new to Prozac myself and have found my anxiety (which can veer into OCD-Land) is much worse. Including night -time anxiety. But it's kicking depressions butt.

Edited by Shatneresque, 29 May 2012 - 07:32 AM.

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I feel better already!

#3 notfred


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Posted 29 May 2012 - 07:43 AM

No reactions that I know of and a med interaction check does not turn any up. Given how common these two meds are if there is a serious interaction it would be well know. People get tolerant to Melatonin. Caffeine increases the effectiveness of Melatonin, that's to only interaction I came up with.

Edited by notfred, 29 May 2012 - 07:43 AM.

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I am in full remission (DSM IV 296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.


Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Aripiprazole 15 mg (Abilify), Eszopiclone 6 mg (Lunesta), Vyvanse 70 mg (Lisdexamfetamine), Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal)
PRN: Belsomra 20 mg (Suvorexant)  Clonazepam 1-2 mg (Klonopin), Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8-16 mg (Zofran)

Supps: Multi-vitamin/mineral, Vitamin D-3 2,000 IU, Omega-3-acid ethyl esters 4 g (Lovaza), Hemp seed oil 2 g (ALA), CoQ10 100 mg, L-Glutathione 200 mg, Iron 65 mg (Ferrous Sulfide)

Dx: Depression, Insomnia, ADHD-PI, Temporal Lobe Epilepsy, Dyspraxia, Tremor, Iron and Vit. D deficient 

I also take allergy and diabetes + it's complications meds, Truvada, Turmeric 500 mg PRN

All doses are a daily total.

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