Surmontil (Trimipramine Maleate)
Posted 14 March 2012 - 11:18 PM
I am looking to treat fibromyalgia, disordered sleep, and BP II.
So that's depression, insomnia, and pain. Add anxiety to the list. TCA's scare me because I tried doxepin once, and the following few days were awful. But I am running out of options since Cymbalta was intolerable, and so many other meds have failed. I don't have much faith in the ssri/snri class except for effexor, my concern being effexor might be too activating and blunting. (However, doxepin seemed nightmarish....) I would be discontinuing Emsam to give trimipramine a try. My pain levels have risen, and the MAOI action of Emsam limits my ability to treat pain.
I would welcome your input.
Posted 30 March 2012 - 08:07 AM
A strongly sedative tricyclic antidepressant, trimipramine has a powerful anxiolytic effect on patients, making it a decent medication for depressive illnesses of the anxious type; its antidepressant effects are also very marked. Unlike most tricyclic medications, this drug exerts only weak inhibitions of monoamine neurotransmitter reuptakes; instead, it seems to exert its therapeutic effect by means of a strong postsynaptic blockade.
Interestingly, this drug is one of the few treatments for insomnia that doesn't alter the stages of sleep, including REM-sleep. Happily, it also seems to brighten up the dreams experienced by patients which is no bad thing! It also exhibits antipsychotic effects, but is not as of yet established as a first or second line treatment for psychosis.
During trimipramine therapy, frequent blood pressure readings and EKG-profiles should be taken, especially at high doses. Blood tests every now and then are also a good idea and patients who are prone to seizures may also want to submit to the occasional EEG test.
Hope that helps!
Diagnosed with: Schizoaffective Disorder of the Depressive Type; Panic; GAD; OCD; PTSD; Transient Ischaemic Attacks
Experience in: Alprazolam, Aripiprazole, Bupropion, Chlordiazepoxide, Citalopram, Clonazepam, Clozapine, Dothiepin, Duloxetine, ECT, EMDR, Fluoxetine, Imipramine, Lamotrigine, Lithium, Lorazepam, Mirtazapine, Moclobemide, Olanzapine, Paroxetine, Procyclidine, Propranolol, Quetiapine, Reboxetine, Risperidone, Sertraline, Sodium Valproate, Tranylcypromine, Trifluoperazine, Venlafaxine, Zolpidem, Zopiclone.
Posted 02 April 2012 - 07:06 AM
Posted 17 July 2012 - 06:25 AM
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