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Effexor Xr Therapeutic At 37.5Mg - Does It Work For You?

Effexor 37.5

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#1 floaty

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Posted 23 February 2012 - 05:50 PM

Hi, I would like to hear from anyone who finds Effexor 37.5mg alone to be a therapeutic dose. I've heard it can happen!
I have troubles with depression, anxiety (though I call it tension!), and eating disorder, which are somewhat but not exclusively, cyclical with periods. I started Effexor 11 days ago. Was great at first as it killed my appetite so I did not even want to binge eat but now that effect has worn off............
I have tried SSRI's with side effects and little efficacy. One day I took tramadol for pain relief (has an SNRI effect as well as being an opiate) and found a surge of energy and sense of calm! It got me off the sofa and wanting to socialise! That's why I asked for Effexor but I dont believe (from what I read here) that the N effect will be present at this dose anyway.
I dont really want to take any more than I need, and of course my ideal dose will become apparent with time, but like the rest of new users, I am impatient and want to hear some good news stories of 37.5!
Thanks.
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#2 floaty

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Posted 28 February 2012 - 01:20 AM

I've been patiently waiting for some replies but nothing, so I will give some info about my experience with Effexor. I know that I trawled the net for hours finding experiences of effexor before I went on it, so maybe this will be helpful to someone else.
The reason I took the meds this time around was that although I have an easy life, a job, no real worries and a loving partner, I was sabotaging everything due to self hatred. I would think desperately about how I could disappear from my life RIGHT NOW and not upset anyone. Leave my job, my house, sell all my stuff really quickly and just disappear. Go live in a place where I could be anonymous and not form any close relationships again. One day whilst feeling despair, I self harded, which I havent done for many years so i decided something had to change and decided on meds (I already meditate, yoga, exercise, self hypnosis, work, have friends, see a psychologist and these werent cutting it).
At the same time as starting effexor 37.5mg in the morning (XR capsule) I started taking iron supplements. I accidentally took 4 times the dose of iron for a week before getting extremely nauseous and getting huge headache. So the nausea I had previosly out down to effexor was, I am 99.9% sure, actually due to the iron overdose!
After 14days the initial feelings of calm and less obsessive thoughts gave way and I once again found myself sabotaging myself and more self hatred and feelings of desperation. This continued for 2 days so I upped the dose to 75mg and have been there for 3 days. I only feel tired (but i can push on physically if I make myself) and like napping. But I was feeling this way BEFORE effexor due to the iron deficiency. In fact, I have noticed that I am doing more things with the effexor, where as before I would have just thought 'screw it, im tired, i dont care what im missing, i cant be bothered, im going to bed'. Now I can at least make myself do more. I dont think I have had any side effects. Its tempting to go up to 150mg just to feel what the norepinephrine effects are like. But i dont want to mess with my natural chemistry more than i have to.
Ive taken paxil before and remember feeling like a junkie coming off it. And the brain zaps. Not looking forward to that again. But hey, whatever gets you through the day.
I also took prozac before and definitely put on a few kgs that have been impossible to shift.
OK, I wont reply to myself anymore! Hope you enjoyed reading and hope you have found your way to get thorugh the day :mad:
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#3 In_Remission_sonador

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Posted 03 March 2012 - 07:00 AM

Hey floaty
Just wondering how you are doing. I have been taking 75mg for about 3wks and its been taking a little bit of the dark cloud away but not enough. Not much help with anxiety. Not feeling so good tday ): i guess i need to go up in dose i guess the norepi. Is affected then. I better hurry and get doc appt though because i been taking samples i had thatsabout to run out. Not a good thing lol!

#4 floaty

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Posted 04 March 2012 - 04:38 AM

Hi Sonador (and anyone else!) how are you?
Yea I need to get to the doc as well as I am all out!
I have taken 75mg for a week and disappointingly, my eating disorder reared its head when I was very anxious. And I had the mother of anxiety attacks over the weekend ..really long! So with that in mind, im tempted to say theyre not working. However!....all the anxiety was due to going away and all my social and body image issues. I nearly let down a very good friend and ended the friendship just so I wouldnt have to go! But the thing is, despite all the anxiety and wanting to bail, i DID go!! Im still having all my cravings to binge eat and the same thoughts about myself but somehow I can carry on better than before. The real test will be the next week as mine seems to follow my cycle and the worst time is coming up!
How are you getting on? Im glad to hear the cloud went away a bit. Ive heard it can take a month to kick in really well but also, i havent heard of many people taking less than 150 (or even 225) dependent on the illness. It seems sometimes people take less, but alongside other meds. Do you take anything else?
Oh, and another great thing ive discovered is Accceptance Commitment Therapy ACT, have you heard of it? Not the right forum to talk about it, but FYI im finding it more effective, and quicker to apply than CBT.
Take care!
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#5 bloodlizard

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Posted 12 March 2012 - 09:18 PM

I want to reply to this so I can follow it--I am thinking of going on Effexor (my pdoc has mentioned it) and am interested in your experience with it. I wish you luck!
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~lizard~


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#6 Blue Heron

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Posted 13 March 2012 - 07:15 AM

You don't have to respond to a topic in order to follow it.
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#7 floaty

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Posted 14 March 2012 - 03:22 AM

Hey Lizard! Thanks for the luck!
Well just like 37.5mg, the 75mg appeared to be working for about two weeks and now I feel the same again. Its given me enought time to re-establish some healthy habbits like going to the gym but the intrusive thoughts are back to normal and i am tired all the time, However, this could very likely be due to that i am waiting for my period. Sorry to add all the gory details! Before my period is when symptoms get worse anyways so i wouldnt be surprised if the symptoms break through at the worst times. My period is late!! So maybe the effexor is affecting that! Hope it comes soon. Any lady who has ever had PMS will understand that its not a good apce to be stuck in.
As ive been so tired, i will take a dose tomorrow am, and then pm, and try pm for a while.
This feels sooooo self indulgent talking about myself on here!
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#8 Crochet4Ever

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Posted 03 April 2012 - 11:23 AM

I am now on 300mg of Effexor xr. I don't even know if that is safe or not. My pdoc did it so I guess it has to be ok, right? But some pdocs can really mess you up too. I'm not sure reading some posts makes me nervous. I don't see anyone above 225mg and even that is kinda rare.

This is only my second time on Effexor xr. I think it has made me lose my appetite this go round.

Well I hope it is still working for most of you guys. Take care.
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#9 martasi2

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Posted 03 April 2012 - 12:09 PM

I am now on 300mg of Effexor xr. I don't even know if that is safe or not. My pdoc did it so I guess it has to be ok, right? But some pdocs can really mess you up too. I'm not sure reading some posts makes me nervous. I don't see anyone above 225mg and even that is kinda rare.

This is only my second time on Effexor xr. I think it has made me lose my appetite this go round.

Well I hope it is still working for most of you guys. Take care.


If you read through some of the posts in the Effexor section it will give you an idea of who's taking what dose and what it did for them. It's a popular med, and people are on different doses depending on what symptoms are being treated and where they are in the titration process. If you've got any doubts about safety, speak to your PDoc just to allay your fears and let him know you're concerned about this.
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#10 floaty

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Posted 04 April 2012 - 03:13 AM

Hey Crochet, hope youre doing OK?
Ive definitely read of people taking 300mg or more, and 300mg is within the therapeutic doses that I have read on patient information leaflets/websites.
I guess youve tried a few meds and so youll know better than anyone that theres no way of knowing if it will work until its working. We are definitely all looking for that magic pill that will bring us out of our pits or relieve high states of anxiety or whatever personal hell we are dealing with. My earlier posts were made when i really needed soemthing to change NOW to get me out of bed, keep me working, just keep me functioning really. I was desperate.
Well the day never came for my ED or anxiety or self sabotage to stop, but on just 75mg OD it has definitely eased. Maybe I should take more to push me further along in recovery but im scared of a higher dose too. At 75mg I can keep my mind quiet enough to do a hard days work and that in itself helps me feel better.
Hopefully you have some other things to help as well as the meds.
Yup, you probably have to trust your pdoc on this one. I know lots of people who have been helped by taking combinations of meds.
I think someone on this site has made a good point in another thread.....the majority of people posting in sites like these could be having issues with meds or current mental health and so tend to share the bad experiences, or their transition experiences. Those who are stable on drugs that work may not be using the sites are they are more concerned with getting out there and living life. So dont be scared by other posts. None of them will predict what happens for you.
As long as you start moving towards the life you want to have, youll know youre making progress.
Good luck!
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#11 jerst458

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Posted 08 May 2013 - 06:39 PM

Hi to the group

My psych doc diagnosed me with an anxiety disorder

He prescribed 75mg of Effexor a day for a week, then 150mg a day

 

I took the 75 mg for two days and felt very agitated..I asked him to call in a script for 37.5mg caps and he did..

 

I have been taking this dose for almost 4 weeks.before that generic Serzone 300mg a day

 

Well after about two weeks the side effects of agitation  fuzzy head were greatly reduced..and I felt more confident. less irritable. less anxiety..

 

I went to the Doc today..he asked me who called in a script for 37.5 mg   I told him you did

 

Told him I felt better..he said it was a placebo effect...Apparently Effexor affects the reuptake of certain serontonin receptors at relatively low doses..but does not "kick in" for norepinephrine until about 150 mg a day  So at 37.5mg acts like an SSRi..and at 150 mg an SSNRi

 

Talked to my pharmacist who said she had many patients taking 37.5 mg caps daily..and what was important was how I felt on this dose..I agree with her

So yes, effexor helps people across a wide range of doses...everyones biochemistry is different..Find the dose that works for you and let the psych doc know this..whether 37.5 mg or 300mg or something inbetween


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#12 jerst458

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Posted 13 May 2013 - 05:36 PM

My psych doc switched me from Serzone/nefazodone to Effexor.

 

I am very high strung..diagnosed with an anxiety disorder

 

The Dr. started me on 75mg xr..and said to increase to 150mg a day in a week

 

After taking 75 mg for 2 days I was all keyed up....asked for and received 37.5 mg caps which I have been taking for about 5 weeks  After about 2 weeks..noticed I was less irritable had more confidence.

 

When I saw him he said this was a placebo effect..talked to my pharmacist who said she had other patients/customers on 37.5 mg xr and what was important was how I felt.

 

Saw dose response curve for Effexor..Apparently prevents the reuptake of serontonin at relatively low doses..Doc wanted to go to 150 mg to tweak norepi receptors...

 

I just feel so much better on the low dose that I do not feel I need to have my norepi reuptake tweaked

 

Jer


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#13 notfred

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Posted 13 May 2013 - 06:00 PM

I just feel so much better on the low dose that I do not feel I need to have my norepi reuptake tweaked

 

Jer

 

 

Since you take nefazodone you are having your norepi tweaked. Maybe it is a good thing.


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PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8 mg (Zofran)

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#14 jerst458

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Posted 23 May 2013 - 10:36 PM

Hi, I would like to hear from anyone who finds Effexor 37.5mg alone to be a therapeutic dose. I've heard it can happen!
I have troubles with depression, anxiety (though I call it tension!), and eating disorder, which are somewhat but not exclusively, cyclical with periods. I started Effexor 11 days ago. Was great at first as it killed my appetite so I did not even want to binge eat but now that effect has worn off............
I have tried SSRI's with side effects and little efficacy. One day I took tramadol for pain relief (has an SNRI effect as well as being an opiate) and found a surge of energy and sense of calm! It got me off the sofa and wanting to socialise! That's why I asked for Effexor but I dont believe (from what I read here) that the N effect will be present at this dose anyway.
I dont really want to take any more than I need, and of course my ideal dose will become apparent with time, but like the rest of new users, I am impatient and want to hear some good news stories of 37.5!
Thanks.


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#15 jazelle401

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Posted 24 May 2013 - 12:35 PM

I started effexor 37.5 3 months ago . It made me jittery and blood pressure rise.  Pdoc added Lexapro , first at  10 mg, then increased to 20 after a weekl, while I continued the 37.5 Effexor.  The plan was that  I would switch to Lexapro and stop the Effexor. Taking the Effexor 37.5 with the Lexapro took away the jittery feeling and my blood pressure returned to normal.  The depression was lifting, so it was decided I would stay on the combo of Effexor 37.5 and Lexapro 20 mg.  I feel much less depressed, only problem is that the fatigue I feel which I associate with the Lexapro.  For some reason, these two meds together work form me.  I would like to not feel so tired, but my sleep has improved overall.  I still take .25 xanax 2 -3 times a day, but mostly 2 .25 Xanax in the evening for sleep. On occasion I take the xanax in the day time if I feel very anxious.

 

I am now also taking pain meds which add to the fatigue, but the effexor/lexapro combo worked for me for depression


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Stoped temazepam about a week ago as it just was not helping. I just use .25-.50 Xanax for sleep now.


#16 alatariel

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Posted 26 March 2014 - 05:05 AM

I'm glad to find this topic, and I posted a similar one myself before find this post. I'm new here, and started on 37.5 of generic effexor a month ago. It's been like a miracle drug. My "normal" is whatever the opposite of high-strung would be, low-strung? So laid-back I may as well be a zombie? My give-a-shit meter is permanently broken? Anyways, on this low dose my desire to binge-eat is gone, my desire to binge-drink is gone, I give-a-shit about normal things like doing the dishes after dinner, I'm not yelling at my kids for nothing, and my ever-circling mind has slowed down to normal speed, oh and my constant ideopathic pain is gone.

 

My worry is that this dose isn't even strong enough to actually be working as anything other than a placebo, and maybe I should switch to a less-potentially-hazardous placebo? Or has anyone ever had such a low dose work for them?


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current meds; generic effexor 37.5, diuretic for borderline high BP

what didn't work in the past: Paxil, Wellbutrin, Prozac, Abilify, St. John's Wort, Vit D, fish oil, exercise, self-help books, talk-therapy


#17 tiredof it

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Posted 09 April 2014 - 01:15 PM

Hi,

I am new to this forum but I felt it was time to finally write something after months of looking and trying to find answers from people that may be going through what I am going through. I have been dealing with this anxiety nightmare since October 2013. My anxiety just started and hasnt gone away. It has been the hardest months of my life. I finally gave in and went to 3 different Psychiatrist who all prescribed Effexor since my sister had taken it before. I had read so many horror stories of the withdraws that I begged my Psych to start me on Celexa instead. I was on Celexa for about 6 months but the anxiety came back full force. I went back to the Psych that actually seems to know what he is talking about and he again said I shoud try the efexor so I finally gave in 3 weeks ago. I am currently on the 37.5 dose (3 weeks) and I am feeling better however i drink a glass of wine everynight to stay calm so Im not sure its doing enough. My Psych says I need to raise it to 75mg at some point but I am so afraid of the side effects and the withdraws later on. I do know that I could never go back to how I was bc it was terrible, a constant knot in my stomach. I am starting to feel depressed which i didnt feel before that much but again he says its bc we need to increase the dose. I was hoping the 37.5 would be enough and still am so when i do have to get off of it it it wont be that hard. How do I knw if its enough, anyone have had not so bad side effects going from one dose to the other? Any help and positive vibes would be greatly appreciated :(

Thanks for listening


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#18 mmcdski21

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Posted 04 May 2014 - 07:21 PM

I am on 375mg and still not feeling the positive effects of it yet. Anyone had experience on a higher dose than that? I was also thinking of switching to Pristiq.


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#19 obsidian3

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Posted 04 May 2014 - 11:15 PM

tired of it  ...  do remember that every one posts their dramatic or disastrous neuro-psych drug experiences and almost no one reports the zillions of successful and uneventful events.

IME Effexor is a very effective SSNRI that has anxiolytic, antidepressant, anti-inflammatory and pain-moderating applications.

 

Yep, 37.5 mg is a very low dose but it could be therapeutic for you and will probably be significantly more effective at 75 mg.  

I found changing Effexor doses quite uneventful,  I had no troubling side effects,  and the once that I discontinued (to shift to Amitriptyline) I did so without any drama at all.                                                                          

 

You might do well backing up your Effexor with a drug that purely targets anxiey.   PlatypusBear often cites Buspar as highly effective for anxiety if it is used as a first line Rx ...  it is ineffective  though if any of the Benzodiazepines have already been used  (Dymphn's Law and totally true).

Often a lower dose of two drugs can be more successful than a single med.   But take your doc's advice and increase to 75 mg first.

It is extremely common to have a rocky time when beginning a new drug and it takes 6 weeks or more for the best AD drugs to be maximally effective.    You have to keep in mind that because your principal symptom is anxiety you have a double burden when it comes to treatment  ...  you carry the first heavy load of anxiety : and then you add in a second load of fear on behalf of the new meds.  Just Not Fair !!!

 

You know that no pdoc is going to prescribe a drug  'just because your sister was on it'.    Especially when 2 or 3 pdocs all concur on one drug it is probable that the drug best targets your particular Brain Cootie.     Understanding your anxiety and fear is essential ; and this site is invaluable for experience, technical knowledge, honesty, and willingness to share.

 

So take a deep breath,  join a yoga meditation class, and get your courage up to increase the Effexor dose to 75 mg and slog on for enough weeks for it to become effective  ...  and then be prepared to add Buspirone if you need to.


Edited by obsidian3, 04 May 2014 - 11:50 PM.

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Current meds : 100mg Amitriptyline : 200mg Quetiapine :1200mg Lithium  : 80mg Propranolol :  Methotrexate :
                         Prednisolone 5-50mg prn : Ergometrine prn : Clorphenamine 12 mg prn : Baclofen 25 mg
 
Rx that has worked in the past :        ECT x 16 once only 1966, plus several x 3 'top-ups'  : Parnate : Na Valproate : Propranolol : Venlafaxine : Diazepam : various Opioids : Olanzapine : Haloperidol.                    
                          
I forget a couple but Hey it's been a long, long time.                                                          
                          No long list of messy failures  ...  Sheer luck I guess !


#20 obsidian3

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Posted 04 May 2014 - 11:45 PM

mmcdski  ...  I've never been above 375 mg.  Swapped to the TCA Amitriptyline when I had this problem.       

 

alatariel  ...  37.5 mg can absolutely be therapeutic and if you continue to find it so the give praise and thanks an continue with gratitude.        There is nothing either specifically or generally hazardous about Effexor.    As I listed above, it is an good anxiolytic, antidepressant,  anti-inflammatory and pain moderator. So your reduced idiopathic pain just proved to be treatable.

Great.          

IMO you would be genuinely crazy to swap to another drug if Effexor is working.

Switching to another drug is really hazardous .  There are fora full of sad tales of folk changing or stopping a drug/drugs ... either because they felt better or because they heard that some other med was less of a potential problem.  The nasty thing is that once an effective drug is discontinued there is a significant risk of it never working as well again.  If it works ...  stick with it.

There may come a time when you require increases in dose and that's just fine : Effexor is a sound drug and not more hazardous than any other neuro-psych drug that we folk who are Mentally Interesting use to keep us functioning.


Edited by obsidian3, 04 May 2014 - 11:47 PM.

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Current meds : 100mg Amitriptyline : 200mg Quetiapine :1200mg Lithium  : 80mg Propranolol :  Methotrexate :
                         Prednisolone 5-50mg prn : Ergometrine prn : Clorphenamine 12 mg prn : Baclofen 25 mg
 
Rx that has worked in the past :        ECT x 16 once only 1966, plus several x 3 'top-ups'  : Parnate : Na Valproate : Propranolol : Venlafaxine : Diazepam : various Opioids : Olanzapine : Haloperidol.                    
                          
I forget a couple but Hey it's been a long, long time.                                                          
                          No long list of messy failures  ...  Sheer luck I guess !



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