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Quetiapine Causing Underactive Thyroid?


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#1 historymum

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Posted 06 February 2012 - 01:39 PM

I've done a search, but can't find anything here on the possible connection between quetiapine and hypothyroidism. I found this http://www.ncbi.nlm....pubmed/10772436 (and there are a few other studies to the right of that page) and http://www.drugs.com...de-effects.html, which reports a decrease in T3 and T4 levels, and an increase in TSH levels.

Does anyone have any further information on this? I'm interested in getting a sense of how common this problem is, and at what dosages it tends to become a problem.

(Reason for asking: My TSH levels had been level for a while and everything seemed fine. However, about 4 weeks after increasing my quetiapine, I went to my GP to complain about a return of symptoms; a blood test showed that my TSH levels had increased. I'm wondering whether there's a relationship there. I'd never had any problems with my thyroid levels until about 2 months after I started quetiapine.)
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#2 notfred

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Posted 06 February 2012 - 02:04 PM

The most obvious place to start research is with the PI. You want section 5.14:

http://www1.astrazen...pi/Seroquel.pdf
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Psyc meds: Aplenzin 522 mg, Abilify 15 mg, Vyvanse 70 mg, Lunesta 6 mg, Levetiracetam 2000 mg, Propranolol ER 60 mg
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I am in full remission (296.36) from Depression. ADD, insomnia, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

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#3 notfred

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Posted 06 February 2012 - 05:32 PM

I was not on a computer that could copy and paste from a pdf, here you go:

5.14 Hypothyroidism
Adults: Clinical trials with quetiapine demonstrated dose-related decreases in thyroid hormone
levels. The reduction in total and free thyroxine (T4) of approximately 20% at the higher end of
the therapeutic dose range was maximal in the first six weeks of treatment and maintained
without adaptation or progression during more chronic therapy. In nearly all cases, cessation
of quetiapine treatment was associated with a reversal of the effects on total and free T4,
irrespective of the duration of treatment. About 0.7% (26/3489) of SEROQUEL patients did
experience TSH increases in monotherapy studies. Some patients with TSH increases needed
replacement thyroid treatment. In the mania adjunct studies, where SEROQUEL was added to
lithium or divalproex, 12% (24/196) of SEROQUEL treated patients compared to 7% (15/203)
of placebo-treated patients had elevated TSH levels. Of the SEROQUEL treated patients with
elevated TSH levels, 3 had simultaneous low free T4 levels.
In all quetiapine trials, the incidence of potentially clinically significant shifts in thyroid
hormones and TSH were*: decrease in free T4, 2.0% (357/17513); decrease in total T4, 4.0%
(75/1861); decrease in free T3, 0.4% (53/13766); decrease in total T3, 2.0% (26/1312), and
increase in TSH, 4.9% (956/19412). In eight patients, where TBG was measured, levels of TBG
were unchanged.


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Dx: Major Depressive Disorder, Attention Deficit Disorder PI, Refractory Insomnia, CSA, Temporal Lobe Epilepsy, Dyspraxia, Tremor
Psyc meds: Aplenzin 522 mg, Abilify 15 mg, Vyvanse 70 mg, Lunesta 6 mg, Levetiracetam 2000 mg, Propranolol ER 60 mg
Other: Fenofibrate, Atorvastatin, Lisinopril, Hctz, Asprin, Metformin, Januvia, Ranitidine, Cetirizine, Nasalide, Montelukast
PRN's: Lorazepam, Alprazolam, Dextroamphetamine, Propranolol, Cyproheptadine, Patanol, Prednisone, Ipratropium, Ondansetron, Hydrocodone, Doxepin
Supplements: Fish Oil 6 g, Multi-vitamin/mineral, vitamin D 1,500 IU

I am in full remission (296.36) from Depression. ADD, insomnia, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

J'ai seul la clef de cette parade sauvage.
Arthur Rimbaud, Les Illuminations, Parade

"I think you are on enough medications." --my pdoc
 

Dr. Frankenstein: You know, I'm a rather brilliant surgeon. Perhaps I can help you with that hump.

Igor: What hump?

 


#4 historymum

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Posted 07 February 2012 - 02:05 PM

Thank you! I've never seen one of those before - I'll know about that for the future.
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Failed med's: Sertraline, Citalopram, Trazodone, Olanzapine, Quetiapine XR, lithium, Abilify

#5 viking_munchkin

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Posted 08 February 2012 - 02:34 AM

I was literally just wondering the same thing... I have never had any trouble with my thyroid before, but since I have started on quetiapine I have developed what my GP calls "borderline hypothyroidism".
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Diagnosed with: Depression; Anxiety; Insomnia

Current Meds: Quetiapine 300mg

Experience in: Citalopram 60mg; Temazepam 10mg; Mirtazapine 30mg


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#6 Meylis

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Posted 26 May 2012 - 10:50 AM

I started having Restless legs since taking Seroquel. One of the causes of RLS is hypothyroidism. I thought it was coincidence, now it is getting closer to a fact.
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#7 LadleFullOfNeurons

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Posted 11 August 2012 - 06:48 PM

Yes, I have been taking 700 mg of Seroquel XR and after 1 year I had to be put on 100 micrograms of Levothyroxine to negate the effects of Seroquel on my thyroid. 1 year later, my thyroid is going even more out-of-whack. I have 6 monthly bloods to check liver function and thyroid and Lithium levels.
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