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Getting Off Of Risperdal


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#1 sleepy

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Posted 22 January 2012 - 07:11 PM

I tried to quit Risperdal cold turkey a few years ago. Big mistake, I know. I went for more than half a year with the worst depression imaginable and probably hyperglycemia, because I was urinating 30 or more times a day. I then starting bawling uncontrollably in public places. I had to get back on it and I've been relatively fine since, but I've had enough of the side effects, and every so often, I start getting terrible withdrawals, even though I'm still taking the medication regularly. I am down to .5mg though.

Has anyone been on the drug for a few years and successfully gotten off of it without long-term consequences?

If that nightmarish depression returns as a withdrawal symptom, should I tough it out, or wait it out and see if I ever get over it completely, or should I have some other medication prescribed to soften that blow?
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One slip, and down the hole we fall. It seems to take no time at all. A momentary lapse of reason, that binds a life for life. A small regret, you won't forget, there'll be no sleep in here tonight.






#2 notfred

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Posted 22 January 2012 - 07:59 PM

If you got depressed after stopping it and it lasted half a year, that is most likely your depression returning and not withdrawal. So the med was keeping the depression at bay. This indicates you do indeed need to be on something to treat your depression.
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I am in full remission (296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Aripiprazole 15 mg (Abilify), Eszopiclone 6 mg (Lunesta), Vyvanse 70 mg (Lisdexamfetamine), Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal)
PRN: Clonazepam 1-2 mg (Klonopin), Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8-16 mg (Zofran)

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I also take allergy and diabetes + it's complications meds.

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#3 Tryn

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Posted 22 January 2012 - 08:05 PM

If your depression returns it's most likely not a symptom of withdrawal. It's probably your brain returning to it's unmedicated state. Or less medicated state

If you are taking the medicine regularly you should not be having withdrawal symptoms. What kind of symptoms are you having? What kind of side effects? Has your psych assisted you in lowering your dosage?

edited to fix the dumb

Edited by girrl88, 22 January 2012 - 08:06 PM.

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#4 sleepy

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Posted 23 January 2012 - 05:40 AM

The depression after getting off the med was the most intense psychic pain I've ever experienced. I was bed ridden, I couldn't read or watch television, as everything was so offensive that it made me sick to my stomach. My brow was permanently affixed in the maximum furrowed state possible and I would spend all day and night begging the gods to kill me, and I had constant, horrible nightmares. When a bad thought, like a past mistake, would enter my mind, I'd get a shock of physical pain throughout my body, so I would have to repeat a nonsense phrase thousands of times a day. I thought I knew what depression was, until I tried to get off risperdal, and I've heard this from other people as well.

My GP did assist me in lowering my dosage, The withdrawals from that lasted more than a month. The intense anxiety I had has decreased measurably, and I'm actually almost able to hold a conversation now.

Withdrawals are hard to describe. It's kind of a pressure in my head with an extreme dizziness and slight nausea. My hands shake and my teeth chatter (my teeth are chattering now and have been for a week). I have to pee every ten minutes. It's not pleasant by any stretch. These withdrawals occurred before I reduced the dosage and would sometimes last a month.

Side effects are drowsiness, inability to concentrate or perform complex tasks, increased anxiety, zero libido, loss of interest in all things.
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One slip, and down the hole we fall. It seems to take no time at all. A momentary lapse of reason, that binds a life for life. A small regret, you won't forget, there'll be no sleep in here tonight.


#5 bergsonisme

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Posted 23 January 2012 - 07:16 AM

Risperdal is probably the one medication I quit cold turkey. I took it for about a month to curb an euphoric mania episode (I did taper up), but stopped it when I became aboulic -- the sign, according to pdoc1, that the danger was gone and normalcy could be restored, with no withdrawal effects. Chronic use may differ considerably though.
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#6 Tryn

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Posted 23 January 2012 - 10:10 AM

The depression after getting off the med was the most intense psychic pain I've ever experienced. I was bed ridden, I couldn't read or watch television, as everything was so offensive that it made me sick to my stomach. My brow was permanently affixed in the maximum furrowed state possible and I would spend all day and night begging the gods to kill me, and I had constant, horrible nightmares. When a bad thought, like a past mistake, would enter my mind, I'd get a shock of physical pain throughout my body, so I would have to repeat a nonsense phrase thousands of times a day. I thought I knew what depression was, until I tried to get off risperdal, and I've heard this from other people as well.

Risperdal can cause depression as a side effect but if you're having depression for that long after you've quit taking it then that is most likely your own depression returning. As you said yourself, you experienced this depression for over 6 months after you'd gotten off of the med. This medication is out of your system in about 4-5 days.

My GP did assist me in lowering my dosage, The withdrawals from that lasted more than a month. The intense anxiety I had has decreased measurably, and I'm actually almost able to hold a conversation now.

Be careful having a GP prescribing you psych meds. They do not always have the expertise to handle these things. The Prozac is probably something that your GP knows plenty about. He/she may not know so much about the Risperdal as it's in a more complex class of meds. That requires a bit more finesse and training than most GPs get and most GPs don't stay up to date on the psych med journals, they simply don't have enough hours in the day.

Withdrawals are hard to describe. It's kind of a pressure in my head with an extreme dizziness and slight nausea. My hands shake and my teeth chatter (my teeth are chattering now and have been for a week). I have to pee every ten minutes. It's not pleasant by any stretch. These withdrawals occurred before I reduced the dosage and would sometimes last a month.

To me these read as side effects. dizziness and nausea, tremor and polyuria. Having to urinate that often may also be a sign of increased blood sugar so you should be getting some blood tests done regularly to check on that. What concerns me here is the teeth chattering. It could be an emotional response or it could be something more, have you told your GP about it?

Side effects are drowsiness, inability to concentrate or perform complex tasks, increased anxiety, zero libido, loss of interest in all things.

Risperdal has a lot of side effects that a lot of people get. Perhaps you could make a list of the side effects that really bother you, it seems that the impaired concentration is one. (I understand, my meds give me that as well.) and present these to your doctor and ask to stay away from meds that tend to have these side effects. You must understand that there is no perfect med out there, everything has it's down side, but there are plenty of meds that don't have the concentration issues or don't have them to the same extent. - Plus you're taking Prozac, it's hard to sort out what side effects are from which med when you're on more than one med. It could be from one or the other or a combo of the two together.

I would also recommend trying to get a psych. Nothing against your GP but psychs are specifically trained for this and keep up with the latest information. If you had any other specific illness you'd go see a specialist, this should be no different.
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#7 sleepy

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Posted 23 January 2012 - 10:19 AM

I'll have to go back to the free mental health clinic, where at least there's a resident psychiatric doctor. I don't want to be on an antipsychotic anymore. It makes like practically unbearable. Perhaps I'll get off of it, under the care of the free clinic, and they can prescribe another SSRI or similar to take that edge off.

I did read somewhere that, if you quit Risperdal cold turkey, and probably most especially if you've been on it for a good while, that it makes your depression harder to treat thereafter. Maybe it altered my brain chemistry enough that it made my depression much worse.

I like the Prozac, and have had no side effects from it, aside from weight gain. It isn't nearlly enough by itself though.
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One slip, and down the hole we fall. It seems to take no time at all. A momentary lapse of reason, that binds a life for life. A small regret, you won't forget, there'll be no sleep in here tonight.


#8 dymphna

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Posted 23 January 2012 - 12:55 PM

I'll have to go back to the free mental health clinic, where at least there's a resident psychiatric doctor. I don't want to be on an antipsychotic anymore. It makes like practically unbearable. Perhaps I'll get off of it, under the care of the free clinic, and they can prescribe another SSRI or similar to take that edge off.

I did read somewhere that, if you quit Risperdal cold turkey, and probably most especially if you've been on it for a good while, that it makes your depression harder to treat thereafter. Maybe it altered my brain chemistry enough that it made my depression much worse.

I like the Prozac, and have had no side effects from it, aside from weight gain. It isn't nearlly enough by itself though.


No.

Risperdal doesn't alter your brain chemistry and make your depression worse. Your depression evolves all by itself, your illness gets worse all on its own.

Repeatedly starting and stopping drugs makes it harder to treat your illness. This is not specific to Risperdal, this happens with any medication for a chronic condition.

If you are taking / have taken a medication that did absolutely nothing for your symptoms and subsequently quit it, that would be something different. But quitting a medication that is alleviating one's symptoms only to have said symptoms return with gusto should come as no surprise.


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#9 sleepy

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Posted 23 January 2012 - 02:03 PM

Well then, I am an incredibly depressed mofo. Almost completely non functional without medication.

I'm able to quit Prozac with no withdrawls, and can go for months without any discernable difference. I did this once, and went about a year without it, but I eventually returned to my highly irritable self, and in the interest of those who have to deal with me, I got back on it.
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One slip, and down the hole we fall. It seems to take no time at all. A momentary lapse of reason, that binds a life for life. A small regret, you won't forget, there'll be no sleep in here tonight.


#10 bengaltiger

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Posted 23 January 2012 - 02:06 PM

By stopping risperdal, you've rocked your brain more than you think.

You have been on Prozac + Risperdal. That is a very potent, symbiotic combination.... Adding risperdal to Prozac significantly amplifies the AD effect than if u just were taking Prozac. It's a super-charged AD.

I can tell u from experience. By itself, risperdal actually worsened my depression. But adding it to Prozac turned the Prozac into a monster.

Incredibly strong. Just my experience.
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#11 sleepy

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Posted 23 January 2012 - 04:51 PM

By stopping risperdal, you've rocked your brain more than you think.

You have been on Prozac + Risperdal. That is a very potent, symbiotic combination.... Adding risperdal to Prozac significantly amplifies the AD effect than if u just were taking Prozac. It's a super-charged AD.

I can tell u from experience. By itself, risperdal actually worsened my depression. But adding it to Prozac turned the Prozac into a monster.

Incredibly strong. Just my experience.


By AD, do you mean attention deficit? My new pharmacist was required to warn me that those two medications have a negative affect on each other, or something to that effect.
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One slip, and down the hole we fall. It seems to take no time at all. A momentary lapse of reason, that binds a life for life. A small regret, you won't forget, there'll be no sleep in here tonight.


#12 notfred

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Posted 23 January 2012 - 05:17 PM

AD=antidepressant.

Prozac may increase plasma concentrations of Risperdal so watch your dose of Prozac. Increase slowly, you may need less than if you were taking Prozac alone. I would not call this a negative effect.
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I am in full remission (296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Aripiprazole 15 mg (Abilify), Eszopiclone 6 mg (Lunesta), Vyvanse 70 mg (Lisdexamfetamine), Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal)
PRN: Clonazepam 1-2 mg (Klonopin), Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8-16 mg (Zofran)

Supps: Multi-vitamin/mineral, Vitamin D-3 2,000 IU, Omega-3-acid ethyl esters 4 g (Lovaza), Hemp seed oil 2 g, CoQ10 100 mg, L-Glutathione 200 mg

Dx: Depression, Insomnia, ADHD-PI, Temporal Lobe Epilepsy, Dyspraxia, Tremor

I also take allergy and diabetes + it's complications meds.

All doses are a daily total.


#13 sleepy

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Posted 08 March 2012 - 07:23 AM

Well, I quit risperdal 3 days ago. Still having the dizzy, wired withdrawals. It might last a week to a month. Like clockwork, my blood sugar has gone haywire. I get extremely hot after eating. Pretty soon, this will be permanent. I wish there was a medication to counteract the ill effects of risperdal withdrawal. I can't tell my family about any of this because my sister and her husband think i'll become a deranged axe murderer if I quit risperdal, and we live on the same property.

I have an appointment at the free clinic in a few weeks. I'll have to get on something else, but I'll never take an antipsychotic again. I'm on an SSRI. Anyone have any general advice on which generaql direction to take? Maybe seraquel? This is for major depression, and I know everyone is different.


edit: day six or seven, still wired, dizzy, blurry vision, sick, headaches, extreme drowsiness, extreme body temperature fluctuations, chattery teeth, shaky hands, random nausia, mental fog, nightmares.

Day eight, and I feel fucking excellent. I've read about a temporary euphoric state after getting off medications. There's a name for it, and I expect a crash and burn to come, but I'm enjoying this while it lasts. I can feel music again and I'm listening to Physical Graffiti. Bliss.

Edited by sleepy, 12 March 2012 - 07:28 PM.

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One slip, and down the hole we fall. It seems to take no time at all. A momentary lapse of reason, that binds a life for life. A small regret, you won't forget, there'll be no sleep in here tonight.


#14 metzen

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Posted 17 April 2013 - 10:43 AM

Hi,

I've experienced that depression you are talking about when dropping risperidone, I'm now on 6 mg and would like to start reducing. I've been told you have to leave it so slowly during the same time you took it to a maximum of 2 years...

you are you now? have you tried leaving it again?


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#15 Klonopin-up-girl

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Posted 29 April 2013 - 08:38 PM

This is my second attempt at getting off Risperdal. The weight gain is just such a deal breaker for me. I've halved my dose and an okay right now. Stopping is going to be the hard part.
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Past Medicines: Buspar 45mg, Risperdal 1mg, Celexa 60mg, Klonopin 1mg, Temazepam 15mg, Ambien, Lithium 600mg, Tegretol, Paxil, Cymbalta, Seroquel, Trazodone.


#16 lizzyb

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Posted 18 May 2013 - 04:20 PM

I had been on 1mg risperdal for about 2 years, it was originally prescribed for hypomania and difficulty sleeping. I didn't experience any bad side effects and I loved sleeping well, but decided I should try and get off it. It is an anti-psychotic and well, one less med couldn't hurt if it wasn't needed.

 

With pdoc assistance lowered dosage down to 0.5mg for about 10 days and then 0.25mg for about 10 days. As soon as I was completely off it, I could not sleep! Pdoc prescribed Ambien for a month to see if that would help. Nope. I was taking massive doses of melatonin and tryptophan and ambien and I was not sleeping. I ran out of ambien and decided to take 0.25 mg of Risperdal. I slept like a baby! What a relief. I figure, eh it's such a low dosage and it works.


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Levothyroxine 175mcg

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past meds:

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prozac

paxil

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#17 Klonopin-up-girl

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Posted 19 May 2013 - 02:35 PM

I'm off and couldn't be happier! I don't sleep as well, true, but I am sleeping!
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Past Medicines: Buspar 45mg, Risperdal 1mg, Celexa 60mg, Klonopin 1mg, Temazepam 15mg, Ambien, Lithium 600mg, Tegretol, Paxil, Cymbalta, Seroquel, Trazodone.


#18 Erika S.

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Posted 14 October 2013 - 09:13 PM

I convinced my psych to let me try a slow taper off Risperidal. I have decreased .5mg for three weeks and I'm not sure if I'm having withdrawal symptoms or that I am seeing and feeling life as it is and not altered by the drug. I have been on anti-psych meds for over 40 years. I learned about life while medicated. So I'm not really sure what are 'normal' feelings. I am not sleeping well, but that isn't unusual. I find myself daydreaming more and I have had the sensation that things aren't real at tmes. I read a book, the Etiology of an Epidemic, where I came to understand how my brain has been altered by the meds. I am angry as hell that I am and have been a victim of psych med revolution.
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#19 reggiethistleton

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Posted 02 January 2014 - 04:18 PM

I've seen several people mention what isn't withdrawal--symptoms after months off a drug, etc.--but how long do actual risperidone withdrawals take? I was on 1 mg. for years and have started lamotrigine and tapered off risperidone, finally coming completely off three days ago. I have night sweats, jaw clenching and I can't stop squirming in bed, I have to pee almost every hour and I'm exhausted.

 

This is nowhere as bad as, say, coming off Effexor was, but I'd like to know how long I can expect to feel this way, if anyone else has experience with this. Thanks very much for your help.


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#20 professor13

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Posted 13 May 2015 - 04:06 AM

what exactly does an irreversible antagonist like risperdal do?  is your brain permanently damaged and dead and unable to speak or understand words and you have muscle weakness for life?  I fell down some stairs and had head trauma and was brain damaged for days

 

http://en.wikipedia....ist#cite_note-1

 

I think it's best not to take any drugs and let the brain heal.  I don't know if mirapex, clozapine or cabergoline would make things worse or help.


Edited by professor13, 13 May 2015 - 04:18 AM.


#21 Blue Heron

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Posted 13 May 2015 - 05:11 AM

Professor13, this isn't the site for you. We don't believe in your "drugs are poison" mantra here.


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#22 peacelizard

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Posted 13 May 2015 - 11:07 AM

Make things worse or help? Which is it?
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Dx: Major Depression // Social Anxiety
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#23 professor13

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Posted 13 May 2015 - 11:12 AM

well I don't mean to get into philosophical discussions



#24 Jerod Poore

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Posted 13 May 2015 - 12:38 PM

what exactly does an irreversible antagonist like risperdal do?  is your brain permanently damaged and dead and unable to speak or understand words and you have muscle weakness for life?  I fell down some stairs and had head trauma and was brain damaged for days
 
http://en.wikipedia....ist#cite_note-1


Risperdal is not an "irreversible antagonist," that's just a recently discovered property.  That wikipedia cite is ever so helpful. Try this article: 


A new approach for studying GPCR dimers: drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo

The key word, as far as your misconceptions are concerned, is reactivation.  As in reversing the inactivation of the 5-HT7 receptors that Risperdal and other meds (methiothepin, bromocriptine, lisuride, and metergoline) seem to do, which is news to me.  Your brain isn't permanently damaged, nor do you experience any of the symptoms you describe.  5-HT7 is responsible for mood, sleep, and circadian rhythm.  So they can mess with you, but not to the extent of your fearmongering bullshit.  5-HT2A is also affected, which explains a lot in the way of manic reactions.  It's actually kind of a toss-up as to 5-HT2A receptors being permanently inactivated in some people being a good or bad thing.  Hey - I think you've just explained my year of the most boring dreams ever.  Thanks!

 

I think it's best not to take any drugs and let the brain heal.


Is regarding your own head trauma, or something else?  If the former, that's up to you and your doctor.  If the latter, then find another site to peddle your anti-med crap.
 

I don't know if mirapex, clozapine or cabergoline would make things worse or help.


According to the above-referenced article, clozapine will help.  As will cyproheptadine and some meds either not available in the US or not yet available anywhere.  Plus I don't think it's all that permanent, otherwise I'd still be experiencing symptoms from when I had to stop taking Risperdal.  And APs in general.


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#25 PlatypusBear

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Posted 13 May 2015 - 02:31 PM

 

what exactly does an irreversible antagonist like risperdal do?  is your brain permanently damaged and dead and unable to speak or understand words and you have muscle weakness for life?  I fell down some stairs and had head trauma and was brain damaged for days
 
http://en.wikipedia....ist#cite_note-1


Risperdal is not an "irreversible antagonist," that's just a recently discovered property.  That wikipedia cite is ever so helpful. Try this article: 


A new approach for studying GPCR dimers: drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo

The key word, as far as your misconceptions are concerned, is reactivation.  As in reversing the inactivation of the 5-HT7 receptors that Risperdal and other meds (methiothepin, bromocriptine, lisuride, and metergoline) seem to do, which is news to me.  Your brain isn't permanently damaged, nor do you experience any of the symptoms you describe.  5-HT7 is responsible for mood, sleep, and circadian rhythm.  So they can mess with you, but not to the extent of your fearmongering bullshit.  5-HT2A is also affected, which explains a lot in the way of manic reactions.  It's actually kind of a toss-up as to 5-HT2A receptors being permanently inactivated in some people being a good or bad thing.  Hey - I think you've just explained my year of the most boring dreams ever.  Thanks!

 

I think it's best not to take any drugs and let the brain heal.


Is regarding your own head trauma, or something else?  If the former, that's up to you and your doctor.  If the latter, then find another site to peddle your anti-med crap.
 

I don't know if mirapex, clozapine or cabergoline would make things worse or help.


According to the above-referenced article, clozapine will help.  As will cyproheptadine and some meds either not available in the US or not yet available anywhere.  Plus I don't think it's all that permanent, otherwise I'd still be experiencing symptoms from when I had to stop taking Risperdal.  And APs in general.

 

This makes at least the third time today he's put up the same exact crap.  I gave him a similar explanation on another thread.


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Past meds: Bupropion XL 150 mg, fluoxetine 40 mg, birth control pills, n-acetlycysteine 1000 mg b.i.d.


#26 jook

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Posted 13 May 2015 - 02:31 PM

what exactly does an irreversible antagonist like risperdal do? 

 

I think the proper term should be 'pseudo-irreversible' antagonist.

Wiki is not your friend on this web site.


Edited by jook, 13 May 2015 - 02:36 PM.

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#27 peacelizard

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Posted 13 May 2015 - 03:51 PM

Wiki might lead you to studies that are empirical and peer-reviewed, but it's not a proper source.


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#28 baseru

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Posted 13 May 2015 - 05:11 PM

I think you can take it as a source, just not a definitive source.


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Prn: Xanax up to 3mg;

 

Efffexor,  Cymbalta,  Zoloft,  Valium,  clonazepam, Seroquel,  Abilify,  Ambien, Viibryd, Chantix, Luvox, trazodone


#29 peacelizard

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Posted 13 May 2015 - 05:40 PM

I think you can take it as a source, just not a definitive source.

 

If you can't take it as a definitive source, then why take it as a source? LOL


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Dx: Major Depression // Social Anxiety
Rx: Effexor XR 300mg QD // Wellbutrin XL 450mg QD

       Neurontin 600mg TID // Zyrtec 10mg QD

       Seroquel IR 25mg QHS // 3mg Melatonin QHS
       Klonopin 0.5mg PRN // Inderal 10mg PRN TID
Tx: Psychodynamic // CBT
Rx: Celexa, Prozac, Zoloft, Trilafon
 
Odi et amo. quare id faciam, fortasse requiris? nescio, sed fieri sentio et excrucior

 


#30 baseru

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Posted 13 May 2015 - 07:02 PM

Because sometimes things are explained better on Wikipedia, which makes it a good beginning source.


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Latuda 60mg;   propranolol 80mg;  benztropine 0.25mg (akathisia);   Lamictal 200mg;  Wellbutrin 150 mg;

For sleep (rotating):  Lunesta 6mg;  Seroquel 50mg  

 

Prn: Xanax up to 3mg;

 

Efffexor,  Cymbalta,  Zoloft,  Valium,  clonazepam, Seroquel,  Abilify,  Ambien, Viibryd, Chantix, Luvox, trazodone



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