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Transition From One Generic Manufacturer To Another....


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#1 GrayEyes777

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Posted 16 January 2012 - 03:43 AM

I need help with this.

I've been taking generic Trazodone made by Mylan for YEARS, works like a charm. No problem whatsoever with it.

Now Mylan has discontinued making it and I've had another manufacturer sent to me (I think it was "Apotex"?).

Anyway, I tried just switching from one to another overnight as if there would be no problem. No such luck, not when it comes to me and my sensitivity to any possible changes in my "cocktail".

So while I still have some old Mylan pills left over, I'm wondering if there might be an easier way to transition. Because the day after I took the new Apotex pill was the day I felt like complete shit, anxiety, panic attacks, headache, nausea - all the classic withdrawal symptoms. So my assumption is my body is reacting not just to the new pill but still craving the "old pill" also. (Hey, tell me if I'm wrong here, just my rational head thinking about this).

So since I take 50 mg at bedtime, I was wondering if I could mix 25 mg of Mylan with 25 mg of Apotex and gradually get off the Mylan that way. ????

Or should I just jump cold turkey and deal with the crappy symptoms in whatever way necessary?

This totally bites.....but I'd appreciate any recommendations! :mad:
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#2 Tryn

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Posted 16 January 2012 - 04:23 AM

I would think that splitting the dose between the two manufacturers is a good idea. It will give your body some time to slowly adjust to the new chemicals that are being introduced.

Are the pills in a form that is easily split?
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#3 notfred

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Posted 16 January 2012 - 07:45 AM

I would not expect many withdrawal problems from Trazodone
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#4 GrayEyes777

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Posted 16 January 2012 - 03:38 PM

Yeah, most "normal" people don't get Trazodone withdrawal symptoms - unfortunately, I'm one of those super sensitive people that feels EVERYTHING (I've had to "wean" myself off Trazodone before). I just didn't expect to feel such a difference between two different generics.

Girrl88, yes, both pills are easily split. I think I'll try it that way and hope for the best!
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#5 Jerod Poore

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Posted 17 January 2012 - 01:11 PM

I just didn't expect to feel such a difference between two different generics.


That's why I've kept writing, since 2004, that big pharma, and various groups like the AMA, have been lying about all generics being equal and generics being the same as brand. That there can be significant differences between generics is all over the page on brand vs. generic drugs.

Girrl88, yes, both pills are easily split.


According to the NIH page on Apotex's trazodone, their flavor of it isn't scored. You can tell if it's Apotex if it has APO and T50 as the imprints.

From the NIH site. Mylan's inert ingredients: SILICON DIOXIDE MAGNESIUM STEARATE CELLULOSE, MICROCRYSTALLINE STARCH, CORN SODIUM LAURYL SULFATE SODIUM STARCH GLYCOLATE TYPE A POTATO FERRIC OXIDE YELLOW

Apotex inert ingredients: FERUMOXSIL MAGNESIUM STEARATE CELLULOSE, MICROCRYSTALLINE STARCH, CORN SODIUM LAURYL SULFATE SODIUM STARCH GLYCOLATE TYPE A POTATO

If Apotex did make it and the inactive ingredients are the same as what the NIH has listed, ferumoxsil must not be as stable as silicon dioxide. Or something like that. You're getting into pharmacokinetic chemistry that is way over my head.
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#6 Jerod Poore

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Posted 17 January 2012 - 01:12 PM

And rule of thumb: if a tablet isn't scored, then splitting it will screw up the pharmacokinetics even more. So expect the results to be less predictable.
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Current meds: lamotrigine 300mg, topiramate 325mg, buspirone 60mg, protriptyline 60mg, EPA 600mg, methylphenidate 5-10mg, lorazepam 1mg PRN
Past meds (likely incomplete): Abilify, clonazepam, desipramine, diazepam, Gabitril, lithium, Neurontin, Paxil, prochlorperazine, Provigil, Prozac, Risperdal, Seroquel, Serzone, Strattera, Trileptal, Zyprexa


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