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How Long For Protriptyline To Work?


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#1 not.really

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Posted 15 January 2012 - 06:36 PM

I've been taking Protriptyline for about 4 1/2 weeks now. I started out taking 5mg twice a day for the first 3 weeks and have now been on 10 mg twice a day for 1 1/2 week now. Thus far I've experienced no improvement in mood. I really had high hopes for this drug.
I'm also coming off of Venlafaxine, I was on 300 mg, and am currently down to 37.5 mg. I'm currently taking Lamotrigine 200 mg and Saphris 10 mg.
Anyway, should I be feeling anything at all at this point?

I've tried several other drugs; the following with no success: Zoloft, Paxil, Effexor,--which I'm now coming off after being on it for a year--Wellbutrin, Abilify, Seroquel, Xanax, and a couple a other that I can't recall at the moment.

I'm wondering when I should give up on the Protriptyline and ask to try something different. It's been so very long since I've felt normal that I don't even care about feeling happy. I just want to be able to enjoy the things that matter to me.
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#2 notfred

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Posted 16 January 2012 - 12:27 AM

10 mg is kinda low. You can go up to 60 mgs, the normal range is 15-40 mgs.
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Dx: Major Depressive Disorder, Attention Deficit Disorder PI, Refractory Insomnia, CSA, Temporal Lobe Epilepsy, Dyspraxia, Tremor
Psyc meds: Aplenzin 522 mg, Abilify 15 mg, Vyvanse 70 mg, Lunesta 6 mg, Levetiracetam 2000 mg, Propranolol ER 60 mg
Other: Fenofibrate, Atorvastatin, Lisinopril, Hctz, Asprin, Metformin, Januvia, Ranitidine, Cetirizine, Nasalide, Montelukast
PRN's: Lorazepam, Alprazolam, Dextroamphetamine, Propranolol, Cyproheptadine, Patanol, Prednisone, Ipratropium, Ondansetron, Hydrocodone, Doxepin
Supplements: Fish Oil 6 g, Multi-vitamin/mineral, vitamin D 1,500 IU

I am in full remission (296.36) from Depression. ADD, insomnia, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

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"I think you are on enough medications." --my pdoc
 

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#3 not.really

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Posted 16 January 2012 - 08:21 AM

I'm actually on 20 mg right now, 10 mg twice a day. But I've only been on it for 1 1/2 weeks. Before--for the first 3 weeks--I was on just 10 mg.
Either way I guess it's still pretty low. I guess I was mostly wondering if it's normal to not feel any change at all at this point.
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#4 notfred

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Posted 16 January 2012 - 08:27 AM

With every dose change you need to give it a full 6-8 weeks. Don't expect much other than some side effects during those weeks. Side effects generally go away.
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Dx: Major Depressive Disorder, Attention Deficit Disorder PI, Refractory Insomnia, CSA, Temporal Lobe Epilepsy, Dyspraxia, Tremor
Psyc meds: Aplenzin 522 mg, Abilify 15 mg, Vyvanse 70 mg, Lunesta 6 mg, Levetiracetam 2000 mg, Propranolol ER 60 mg
Other: Fenofibrate, Atorvastatin, Lisinopril, Hctz, Asprin, Metformin, Januvia, Ranitidine, Cetirizine, Nasalide, Montelukast
PRN's: Lorazepam, Alprazolam, Dextroamphetamine, Propranolol, Cyproheptadine, Patanol, Prednisone, Ipratropium, Ondansetron, Hydrocodone, Doxepin
Supplements: Fish Oil 6 g, Multi-vitamin/mineral, vitamin D 1,500 IU

I am in full remission (296.36) from Depression. ADD, insomnia, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

J'ai seul la clef de cette parade sauvage.
Arthur Rimbaud, Les Illuminations, Parade

"I think you are on enough medications." --my pdoc
 

Dr. Frankenstein: You know, I'm a rather brilliant surgeon. Perhaps I can help you with that hump.

Igor: What hump?

 



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