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How Long For Protriptyline To Work?


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#1 not.really

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Posted 15 January 2012 - 06:36 PM

I've been taking Protriptyline for about 4 1/2 weeks now. I started out taking 5mg twice a day for the first 3 weeks and have now been on 10 mg twice a day for 1 1/2 week now. Thus far I've experienced no improvement in mood. I really had high hopes for this drug.
I'm also coming off of Venlafaxine, I was on 300 mg, and am currently down to 37.5 mg. I'm currently taking Lamotrigine 200 mg and Saphris 10 mg.
Anyway, should I be feeling anything at all at this point?

I've tried several other drugs; the following with no success: Zoloft, Paxil, Effexor,--which I'm now coming off after being on it for a year--Wellbutrin, Abilify, Seroquel, Xanax, and a couple a other that I can't recall at the moment.

I'm wondering when I should give up on the Protriptyline and ask to try something different. It's been so very long since I've felt normal that I don't even care about feeling happy. I just want to be able to enjoy the things that matter to me.
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#2 notfred

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Posted 16 January 2012 - 12:27 AM

10 mg is kinda low. You can go up to 60 mgs, the normal range is 15-40 mgs.
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I am in full remission (DSM IV 296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Aripiprazole 15 mg (Abilify), Eszopiclone 6 mg (Lunesta), Belsomra 20 mg (Suvorexant), Vyvanse 70 mg (Lisdexamfetamine), Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal), Clonazepam 1 mg (Klonopin),
PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8-16 mg (Zofran)

Supps: Multi-vitamin/mineral, Vitamin D-3 2,000 IU, Omega-3-acid ethyl esters 4 g (Lovaza), Hemp seed oil 2 g (ALA), CoQ10 100 mg, L-Glutathione 200 mg, Iron 65 mg (Ferrous Sulfide)

Dx: Depression, Insomnia, ADHD-PI, Temporal Lobe Epilepsy, Dyspraxia, Tremor, Iron and Vitamin D deficient 

I also take allergy and diabetes + it's complications meds, Truvada

All doses are a daily total.


#3 not.really

not.really

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  • Current Meds:lamotrigine 400 mg, viibryd 40 mg, latuda 80 mg, levoxyl 112 mcg

Posted 16 January 2012 - 08:21 AM

I'm actually on 20 mg right now, 10 mg twice a day. But I've only been on it for 1 1/2 weeks. Before--for the first 3 weeks--I was on just 10 mg.
Either way I guess it's still pretty low. I guess I was mostly wondering if it's normal to not feel any change at all at this point.
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#4 notfred

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Posted 16 January 2012 - 08:27 AM

With every dose change you need to give it a full 6-8 weeks. Don't expect much other than some side effects during those weeks. Side effects generally go away.
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I am in full remission (DSM IV 296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Aripiprazole 15 mg (Abilify), Eszopiclone 6 mg (Lunesta), Belsomra 20 mg (Suvorexant), Vyvanse 70 mg (Lisdexamfetamine), Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal), Clonazepam 1 mg (Klonopin),
PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8-16 mg (Zofran)

Supps: Multi-vitamin/mineral, Vitamin D-3 2,000 IU, Omega-3-acid ethyl esters 4 g (Lovaza), Hemp seed oil 2 g (ALA), CoQ10 100 mg, L-Glutathione 200 mg, Iron 65 mg (Ferrous Sulfide)

Dx: Depression, Insomnia, ADHD-PI, Temporal Lobe Epilepsy, Dyspraxia, Tremor, Iron and Vitamin D deficient 

I also take allergy and diabetes + it's complications meds, Truvada

All doses are a daily total.



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