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Help! Generic Wellbutrin Xl Side Effects !

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#1 ~Tricia~


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Posted 21 May 2011 - 08:59 PM

I have been on Wellbutrin XL 150 mg (generics) for a year now and I have lost 53 pounds.(I had gained the weight by taking prozac for the previous 5 years, so I'm not concerned with the weight loss) It has taken care of my depression, thank goodness. However in October of 2010 the pharmacy changed to the Teva brand and I started getting dry mouth. I then got a canker sore in my mouth that was huge and I took Keflex for 10 days to clear it up. Again in February I got the pain in my mouth and was given another prescription of Keflex, but it didn't work this time. I was sent to an ENT who checked me for throat cancer because I had had oral pain for such a long time, and my father died of oral cancer. (I have never smoked) I was given 10 days of Augmentin to take and the pain went away. I STILL have the dry mouth. The past two refills of the Wellbutrin XL have been a generic from a company named Global, and the dry mouth is even worse. I have only recently become aware that this is all connected. I plan to talk to the pharmacist on Monday and try to find out what company the generic was made by that I started out on and see if I can find a pharmacy in this area that stocks it. Does anyone have any other suggestions? The dry mouth is driving me crazy, my mouth hurts all the time and my lips hurt too.
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#2 Ophelia


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Posted 21 May 2011 - 11:15 PM


Dry mouth is one of the typical side effects of Wellbutrin and most other antidepressants. I am guessing that the dry mouth led to the canker sore, which then got infected, which is why you had to be on antibiotics. You could check with your doctor to see if that's the case and what to do about it. It's not a side effect to tolerate because it's not good for your oral health.

Drink lots of water! It will probably help, and it won't hurt unless you drink something like 8 gallons a day (I heard of a woman who did exactly that and had to be in hospital; apparently even water, in excessive quantities, is toxic).

I just googled on "dry mouth treatment" (without the quotes) and got tons of hits, including an article on WebMD which could be helpful. They mention a drug called Salagen but also offer a number of non-drug alternatives.

Current Diagnosis: Bipolar disorder + PTSD
Current cocktail: Lamotrigine 287.5 mg, Seroquel XR 50 mg, Seroqel IR 50mg & PRN as needed, Wellbutrin SR 225 mg, Abilify 0.5 mg, Estradiol 1 mg, Aspirin 81 mg, Tegretol + Wellbutrin + Celexa, Methylin, Provigil, Depakote, Prozac, Pamelor, Dilantin, Tofranil, Elavil, Stelazine, lithium, Haldol, Desyrel, Valium, Nardil, and fish oil (for crying out loud! It threw me into a mixed episode)....
..........and others I can't remember
Supps: Calcium with Vitamin D, Vitamin D, Iron, Multi-Vitamin, Glucosamine with Chondroitin

#3 notfred


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Posted 22 May 2011 - 01:12 AM

I have the same problem with Vyvanse, dry mouth. I find the Biotine products for dry mouth to be excellent. Biotine products are in the toothpaste section at Walgreens and other stores.

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I am in full remission (DSM IV 296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.


Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Aripiprazole 15 mg (Abilify), Eszopiclone 6 mg (Lunesta), Belsomra 20 mg (Suvorexant), Vyvanse 70 mg (Lisdexamfetamine), Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal), Clonazepam 1 mg (Klonopin),
PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8-16 mg (Zofran)

Supps: Multi-vitamin/mineral, Vitamin D-3 2,000 IU, Omega-3-acid ethyl esters 4 g (Lovaza), Hemp seed oil 2 g (ALA), CoQ10 100 mg, L-Glutathione 200 mg, Iron 65 mg (Ferrous Sulfide)

Dx: Depression, Insomnia, ADHD-PI, Temporal Lobe Epilepsy, Dyspraxia, Tremor, Iron and Vitamin D deficient 

I also take allergy and diabetes + it's complications meds, Truvada

All doses are a daily total.

#4 ~Tricia~


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Posted 22 May 2011 - 09:29 AM

Thank you so much for your responses! It's so nice to know I'm not alone.
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#5 In_Remission_chutesandladders

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Posted 17 June 2011 - 01:25 PM

If you find what generic gives you the least side effects/works the best you can ask your doctor to write "must use ___brand" on the prescription. Or if that doesn't work, you can ask the pharmacy before you fill your prescription what generic they use (different pharmacies use different generics) and then only fill your prescription at the pharmacy that has the generic that works for you. Watson generic doesn't work at all for me, it's like not taking the meds at all. But the teva generic is a world of difference. Also, I agree with Notfred, the Biotine toothpaste really helps my dry mouth and it's over the counter. Good luck. :mad:

#6 egodystonic_James


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Posted 18 June 2011 - 09:48 PM

I'm pretty sure Global is a subsidiary of Teva or is somehow related to Teva. Both brands of bupropion are trash. Try to get them to order another generic, I've heard the Watson one is good. I had Global and compared it to my Teva (which I had stopped taking due to side-effects) and both were the same pill. Big oval yellow pills. The Global made me sick as well.


Edited by egodystonic_james, 18 June 2011 - 09:52 PM.

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-Bipolar 2 (mostly depressed phase)

-Somatoform Pain Disorder

-Cotard Delusion (in partial remission)(No longer in the DSM, but I sure as hell have it and have been dx'd with it)

Seroquel XR (brand-name quetiapine extended-release) 300 mg once daily in the evening

BuSpar (generic buspirone) 15 mg four times daily

Remeron (generic mirtazapine  15 mg once daily at bedtime 

trazodone (generic) 150 mg as needed once daily at bedtime 


Additional meds

-Lpitor (brand atorvastatin) 20 mg daily

-Vitamin D 5000 IU

-Folic Acid 400 mcg



*****In the hospital the last week. Doing better on Zyprexa, Remeron, and especially Paxil.*****



#7 fairymonkey


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Posted 07 March 2012 - 03:49 PM

I have the same experience except its from a brand called Anche. I am immediately going to get the brand name stuff, since I heard from people that they had bad reactions from the generic stuff. My question is, why would this be approved since a lot of people have been having bad reactions from it? I seriously feel crazy and sick at the same time.
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My actual diagnosis: It's still a debate. Psychologists can't seem to diagnose me. Post Traumatic Stress Disorder w/ Depression and anxiety. co-dependency issues.
Past meds: Effexor, Lexapro, Fluoxetine , Bupropion XL ,Klonopin, Ativan, Nortriptyline ,Remeron
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“Sometimes fate is like a small sand-storm that keeps changing directions. You change direction, but the sand-storm chases you. You turn again, but the storm adjusts. Over and over you play this out, like some ominous dance with death just before death. Why? Because this storm isn't something that has nothing to do with you. This storm is you.”
Haruki Murakami, Kafka on the Shore

#8 forgetmenot


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Posted 07 March 2012 - 08:25 PM

I had the same effect at first but it went away. I've taken the Watson brand and loved it. I was switched the some other generic brand, budprion (I know I'm spelling that wrong) when I started getting mail order, and just switched back. The new generic lacked the "oomph" the Watson brand had for me.
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current rx: wellbutrin xl 450 mg, lamictal 300 mg, Haldol 0.5 mg, Saphris 5 mg

 celexa, prozac, navane, xanax, klonopin, vistaril, effexor xr, lithium, abilify, benztropine, buspar, risperidone, trazadone, cogentin, latuda

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